{"id":69231,"date":"2019-10-04T14:14:43","date_gmt":"2019-10-04T08:44:43","guid":{"rendered":"https:\/\/apnlive.com\/?p=69231"},"modified":"2022-03-23T16:19:01","modified_gmt":"2022-03-23T10:49:01","slug":"blood-cancer-drug-ibrutinib-contributes-hypertension-study-reveals","status":"publish","type":"post","link":"https:\/\/apnlive.com\/lifestyle\/blood-cancer-drug-ibrutinib-contributes-hypertension-study-reveals\/","title":{"rendered":"Blood Cancer drug, Ibrutinib, contributes to Hypertension \u2013 A study reveals"},"content":{"rendered":"<p>[vc_row][vc_column][vc_column_text]<span style=\"font-weight: 400;\">Researchers at the Ohio State Wexner Medical Center in a new study found that the blood cancer drug, ibrutinib contributed to new or worsened hypertension within 6 months of treatment.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">The research team also suggests results of the study are the first to tie ibrutinib-related hypertension to other cardiovascular issues, including atrial fibrillation.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">&#8220;This study provides a clearer picture of the extent of hypertension development among patients taking ibrutinib, while allowing us to tease out what ibrutinib-related hypertension means in the long run for other cardiovascular events and survival,&#8221; said lead investigator Daniel Addison, MD, of the Ohio State Wexner Medical Center.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">In an effort to know the long-term incidence, severity, and impacts of hypertension development during ibrutinib use, a study was conducted with 562 consecutive patients treated with ibrutinib for B-cell malignancies between 2009 and 2016.&nbsp;<\/span><\/p>\n<p><span style=\"font-weight: 400;\">The Study also evaluated the relationship of hypertension on ibrutinib to the development of other Major-Adverse-Cardiovascular-Events (MACE), including arrhythmias, myocardial infarction, stroke, heart failure, and cardiovascular death.&nbsp;<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Further, the preventative and modulatory effects of antihypertensives, by medication-class, on ibrutinib-related hypertension were also assessed by the investigators.&nbsp;<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Investigators observed 78.3%(440) patients developed new or worsening hypertension during the follow-up period, which had a median of 30 months.&nbsp;<\/span><\/p>\n<p><strong>Also Read:&nbsp;<a href=\"https:\/\/apnlive.com\/lifestyle\/2-eggs-per-day-not-good-heart-study-63560\">More than 2 eggs per day not good for your heart: Study<\/a><\/strong><\/p>\n<p><span style=\"font-weight: 400;\">The study showed that new hypertension developed in 71.6% of ibrutinib-users with a time-to-50% cumulative incidence of 4.2 months while among those without preceding hypertension, 17.7% developed high-grade hypertension.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Moreover, in multivariable regression containing known predictors of MACE, new or worsened hypertension was associated with increased MACE. No single-antihypertensive class was associated with prevention or control of ibrutinib-related hypertension. However, antihypertensive initiation was associated with a lower risk of MACE , the researching team stated.&nbsp;<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Collectively, these data suggested ibrutinib is largely associated with substantial increase in the incidence and severity of hypertension and that hypertension development may suggest a higher risk of subsequent cardiotoxic events.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">In a release from American Society of Hematology, Addison noted due to the frequency of ibrutinib\u2019s use as a treatment it is important to keep the increased risk profile in mind to protect against additional heart related issues.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">\u201c(Ibrutinib) has become ubiquitous to the treatment of many blood cancers and will continue to be applied to other cancers,&#8221; Addison said. &#8220;Accordingly, we need to find the best ways to manage high blood pressure and protect against other heart-related issues.\u201d<\/span><\/p>\n<p><strong><a href=\"https:\/\/apnlive.com\/lifestyle\">Know more about lifestyle updates and health related tips.<\/a><\/strong><\/p>\n<p>[\/vc_column_text][\/vc_column][\/vc_row]<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Researchers at the Ohio State Wexner Medical Center in a new study found that the blood cancer drug ibrutinib contributed to new or worsened hypertension within 6 months of treatment.<\/p>\n","protected":false},"author":4,"featured_media":69233,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_eb_attr":"","footnotes":"","jetpack_publicize_message":"","jetpack_is_tweetstorm":false,"jetpack_publicize_feature_enabled":true},"categories":[1532],"tags":[81352,81354,81350,81351,81355,81353],"yst_prominent_words":[4509,81341,81346,81348,81339,81349,81344,81347,81340,64146,81336,81334,81333,81342,81337,81335,8417,81343,81338,81345],"ppma_author":[140543],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"https:\/\/d2r2ijn7njrktv.cloudfront.net\/apnlive\/uploads\/2019\/10\/04141312\/download1.jpg","jetpack_sharing_enabled":true,"authors":[{"term_id":140543,"user_id":4,"is_guest":0,"slug":"apnnewsdesk","display_name":"APN Live","avatar_url":"https:\/\/secure.gravatar.com\/avatar\/478eacb893eda88aa6ed8d99b005bf58?s=96&r=g"}],"_links":{"self":[{"href":"https:\/\/apnlive.com\/wp-json\/wp\/v2\/posts\/69231"}],"collection":[{"href":"https:\/\/apnlive.com\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/apnlive.com\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/apnlive.com\/wp-json\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/apnlive.com\/wp-json\/wp\/v2\/comments?post=69231"}],"version-history":[{"count":0,"href":"https:\/\/apnlive.com\/wp-json\/wp\/v2\/posts\/69231\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/apnlive.com\/wp-json\/wp\/v2\/media\/69233"}],"wp:attachment":[{"href":"https:\/\/apnlive.com\/wp-json\/wp\/v2\/media?parent=69231"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/apnlive.com\/wp-json\/wp\/v2\/categories?post=69231"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/apnlive.com\/wp-json\/wp\/v2\/tags?post=69231"},{"taxonomy":"yst_prominent_words","embeddable":true,"href":"https:\/\/apnlive.com\/wp-json\/wp\/v2\/yst_prominent_words?post=69231"},{"taxonomy":"author","embeddable":true,"href":"https:\/\/apnlive.com\/wp-json\/wp\/v2\/ppma_author?post=69231"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}<!-- html is corrupted -->