English हिन्दी
Connect with us

Gadgets

Eggshell-derived nanoparticles can be used for drug delivery

Published

on

Eggshell-derived nanoparticles can be used for drug delivery

By DrShikha T Malik

Eggshells are among the most commonly discarded kitchen waste. Now scientists are putting eggshells to some novel use – drug delivery – by deriving nanoparticles out of them.

A team of scientists at the Indian Institute of Technology (IIT) Madras have developed a method to use eggshells for synthesizing nanoparticles. These nanoparticles could be potential candidatesfor local drug delivery as well as a material for bone grafts.

Research team at IIT-Madras.

Research team at IIT-Madras.

Nanoparticles are extremely tiny particles which can be customized for various biomedical applications like diagnostics, drug delivery etc. Researchers feel eggshell-derived nanoparticles may be suitable for use in humans asthey have tested biocompatibility of calcium phosphate cement made from eggshells as dental implants in preliminary studies in humans. However, eggshell-derived nanoparticles are yet to be tested in humans.

Using microwaves, scientists synthesized carbonated calcium deficient hydroxyapatite (ECCDHA) nanoparticles from egg waste. These nanoparticles are similar to human bone in mineral composition.

In order to check drug delivery efficacy of these nanoparticles, researchers compared them with synthetic hydroxyapatite nanoparticles and found them to be more efficient. They are better in loadingand releasing drugs in a sustained mannercompared to the synthetic nanoparticles.A higher drug-loading capacity means lesser quantity of nanoparticle material is needed for drug delivery.

The efficacy of these particles was analyzed using an antibiotic as a test drug.“Apart from their ability to deliver the antibiotic, eggshell derived apatite nanoparticles also showed higher amount of bovine serum albumin (BSA) protein delivery, which means they may be employed for delivering growth factors for bone regeneration”, Prof. Sampath Kumar, who led the team, told India Science Wire.

In addition to drug delivery, the presence of ions like strontium, magnesium, fluoride and sodium in small amounts in these nanoparticles makes them potentially useful as graft materials for bone regeneration. “Since these eggshell derived particles are very similar to human bone with respect to their mineral composition, we propose that these may be potential candidates for bone substitutesand may be used for treatment of infections associated with bone loss,” said Kumar.

Hydroxyapatite is a major mineral base of human bone and is one of the most studied biomaterials for more than half a century. However, synthetic hydroxyapatite drastically varies from biological apatite found in human bone. It lacks the trace elements, which are highly essential for bone growth and remodeling. “Hydroxyapatite with chemical composition similar to biological apatite would be beneficial for bone applications”, pointed out Dr. M Ramalingam, co-author of the study.

The research team has tested eggshell derived calcium phosphate cements in humans. “Preliminary clinical studies with six patients have indicated clinical efficacy of eggshell derived cements in treating bone (dental) defects, demonstrating complete resorption with new bone formation”, Kumar said. These studies suggest that the eggshell nanoparticles have better physical and biological properties than synthetically derived ones.

The team included R. Jayasree, K. Madhumathi, Rakesh P. Nankar, MukeshDoble, and T. S. Sampath Kumar at IIT Madras;Deepti Rana and MuruganRamalingamfrom CMC Vellore. The study has been published in Journal of Nanoscience and Nanotechnology and was funded by the Department of Biotechnology (DBT).– India Science Wire

Gadgets

OnePlus to launch Nord CE 3 in India, specs and price leaked ahead of global debut

OnePlus may soon expand its affordable smartphone series Nord CE. It is being claimed that the company is going to launch the new OnePlus Nord CE 3 in July this year. As per the leaks, the OnePlus Nord CE 3 will be introduced as a successor to the OnePlus Nord CE 2.

Published

on

OnePlus smartphone

OnePlus may soon expand its affordable smartphone series Nord CE. It is being claimed that the company is going to launch the new OnePlus Nord CE 3 in July this year. As per the leaks, the OnePlus Nord CE 3 will be introduced as a successor to the OnePlus Nord CE 2. The information about the phone has also been revealed ahead of its official debut on many digital platforms. However, the company has not yet given any information regarding the same as yet.

According to a report by My Smart Price, the OnePlus Nord CE 3 is expected to launch in July alongside of OnePlus Nord 3. The tipster also has claimed about the specification of the phone as well. Scroll down to know more about the smartphone.

Read Also: Delhi Liquor Policy Scam: Former AAP Deputy CM Manish Sisodia files bail plea, hearing on March 4

According to tipster Steve Hemmerstoffer (@OnLeaks), the OnePlus CE 3 will come with a display with 120Hz refresh rate, under which the user will be able to have a high definition display quality while playing videos. The handset is also likely to feature a 6.72 inch Full HD Plus AMOLED display. Earlier it was being said that this phone will be introduced with an IPS LCD screen. However, the confirmation is still awaited.

Leaks also suggested that the OnePlus Nord CE 3 is expected to be powered by the octa-core Snapdragon 782G processor coupled with up to 12GB of RAM and up to 256GB of inbuilt storage. The upcoming OnePlus Nord CE 3 could be equipped with three rear cameras. The phone can get a 50-megapixel Sony IMX890 primary sensor, an 8-megapixel ultra-wide-angle lens, and a 2-megapixel macro lens. The phone is expected to get a 16-megapixel sensor for selfie and video calls.

The handset is said to have an in-display fingerprint sensor, a 5000mAh battery with 80W fast charging support, dual-band Wi-Fi, 5G, 4G LTE, Bluetooth and a USB Type-C port.

Indian Army gets jetpack demonstration by Gravity industries in Agra, video viral | WATCH

BJP lashes out at Rahul Gandhi’s statement in Cambridge, Anurag Thakur says defaming India is his habit

Continue Reading

Gadgets

Vivo launches color-changing back panel smartphone V27 Pro in India, check price and specs

The Chinese smartphone manufacturer Vivo has launched its awaited color-changing back panel smartphone V27 Pro in India, along with the lower variant V27. Interested customers can purchase the handset in magic blue and noble black color

Published

on

Vivo V27 Smartphone

The Chinese smartphone manufacturer Vivo has launched its awaited color-changing back panel smartphone V27 Pro in India, along with the lower variant V27. Interested customers can purchase the handset in magic blue and noble black color. Pre-booking of Vivo V27 Pro has started and sales will be from March 6. The sale of Vivo V27 will start from 23 March.

As per the official details, the handset is the upgraded version of the Vivo V25 series, which was launched last year. The company has introduced the Vivo V27 Series with Android 13-based Funtouch OS 13 and MediaTek processor, under which customers will be able to access heavy applications without and lag.

Read Also: Elvish Yadav or Manmohan Yadav? Who stole flower pots in Gurugram in #GamlaChor controversy? Everything you need to know

Know everything about the Vivo’s Vivo V27 and V27 Pro

As per the photos shared by the company, Vivo V27 Pro and Vivo V27 come with a 3D curved screen with a refresh rate of 120Hz that offers users to have a high-definition screen experience while playing any video. It comes with a glass panel that changes color whenever some light or sun rays strike it. Both Vivo V27 Pro and Vivo V27 phones have three rear cameras, and features. The Vivo V27 Pro has a MediaTek Dimensity 8200 processor, while Vivo V27 has Dimensity 7200 5G processor. Both the chipset have been considered the advance chipset in the Indian market.

Price of Vivo’s V27 and V27 Pro

The price of 128 GB storage with 8 GB RAM of Vivo V27 Pro is Rs 37,999. At the same time, the price of 256 GB storage with 8 GB RAM has been kept at Rs 39,999. The 256 GB storage variant with the phone’s 12 GB RAM is priced at Rs 42,999. The price of 128 GB storage with 8 GB RAM of Vivo V27 has been priced at Rs 32,999 and 256 GB storage with 12 GB RAM has been priced at Rs 36,999.

LPG price hike: Domestic cylinder price increased by Rs 50, commercial cylinder price hiked by Rs 350, check the new rates here

Continue Reading

Gadgets

Samsung set to launch Galaxy S23 FE, design and specs leaked ahead of official launch

Published

on

The leading smartphone manufacturer Samsung recently launched the Galaxy S23 series in India, since then, the handsets became the talk of the time. Now the company is all set to attract more customers as it has decided to launch an affordable variant of Samsung Galaxy S23 FE in the country.

Ahead of the official launch, many information such as specs, design leaked on digital platforms, claiming the handset might come with the latest processor with a 120 Hz AMOLE display that will allow users to have a high-definition experience while playing videos or using the phone. As per the leaks, the phone could be equipped with a flagship chipset launched by Qualcomm last year. However, the South Korean tech giant hasn’t revealed anything regarding the same as of now. Not even the price and launch date.

Once launched, interested customers can purchase the smartphone from the company’s authorized store. If one wants it at an additional discount, they can purchase the phone from the e-commerce giant Amazon or Flipkart.

Know everything about Samsung Galaxy S21 FE

Tipster Connor (@OreXda) claims that the Samsung Galaxy S23 FE will be powered by the Snapdragon 8+ Gen 1 processor. It is the second most powerful chipset from Qualcomm after Snapdragon 8 Gen 2. A lot of flagship phones of this year shared the with same Snapdragon 8 Gen 1 such as OnePlus 11R, Xiaomi 12S Ultra, Asus Zenfone 9, Samsung Galaxy Z Flip 4, and Oppo Find N2 among others.

It said that the upcoming Samsung Galaxy S21 FE might replace the company’s feature-loaded smartphone Galaxy A74. It is expected that the company likely to launch the S21 FE at a similar price as A74.


Continue Reading

Trending

-->

© Copyright 2022 APNLIVE.com

Left Menu Icon