Gadgets
Scientists a step closer to potential vaccine against Leptospirosis
~By Shikha T Malik
Leptospirosis – caused by pathogenic bacteria, Leptospira – led to over one million infections globally in 2015. Availability of an appropriate vaccine could have prevented most of them.
Scientists at the Gujarat Biotechnology Research Centre (GBRC) have used sophisticated tools to identify important regions on the bacteria that could play an important role in developing a vaccine for Leptospirosis.
Leptospirosis is a zoonotic disease, meaning it spreads through animals. Farmers or veterinarians frequently exposed to animal urine or swimmers exposed to contaminated water are at high risk. People may get exposed to the bacteria during flooding as well. Vaccinating such high risk groups can protect them from Leptospirosis.
The team at GBRC used high throughput computational tools to identify regions on pathogenic Leptospira, which could be critical in designing an effective vaccine. Using bioinformatics tools, researchers studied the whole set of proteins of bacteria cell (proteome) and its genome.
Research team of GBRC
As a protection mechanism from a pathogen, human body fights back by making antibodies or activating cells that kill other infected cells which scientists refer to as ‘immune response’. Vaccines prepare our bodies by eliciting such response even before one is infected by a pathogen. This way vaccines equip us to fight a pathogen or disease as soon as we are exposed to it.
Researchers have identified certain peptides (small parts of proteins) which could be further tested as potential vaccine candidates that can elicit a strong immune response. These peptides are part of an ‘outer membrane protein’ of the bacterium. This protein is conserved in 46 types of disease causing Leptospira, and if confirmed and further developed into a vaccine, it could provide immunity against all 46 types.
“Identification of target sites is a key step in vaccine design. With the help of modern genomics, proteomics and bioinformatics tools we have analyzed the pathogenic proteome (3654 proteins) to predict the antigenicity (ability to elicit an immune response) and narrowed down to a single protein of high affinity with ability to bind to the antibody present on B-cells for inducing immune response,” explained Dr Jayashankar Das, lead scientist, while speaking to India Science Wire.
Since many different strains or types of Leptospira are present in tropical regions, the team is carrying out more studies on different strains and also testing identified proteins in cells, added Dr Das. “Since this disease is a major concern to farmers as well as livestock breeders, we are also involved in developing an onsite diagnostic kit for leptospirosis with support from the Department of Science and Technology (DST),” he added.
“These peptides represent a novel outcome of the study. They need to be studied further in for their effectiveness in animals and humans. If successful, it could become an important tool in fighting this disease worldwide,” commented Dr Hardeep Vora, R&D Manager at DiaSys Diagnostics India, while speaking to India Science Wire.
The research results have been published in journal, Scientific Reports. The team included Kumari Snehkant Lata, Swapnil Kumar, Vibhisha Vaghasia, Priyanka Sharma, Shivarudrappa B. Bhairappanvar, Subhash Soni and Jayashankar Das. The research work was supported by the Gujarat State Biotechnology Mission. (India Science Wire)
Gadgets
OnePlus to launch Nord CE 3 in India, specs and price leaked ahead of global debut
OnePlus may soon expand its affordable smartphone series Nord CE. It is being claimed that the company is going to launch the new OnePlus Nord CE 3 in July this year. As per the leaks, the OnePlus Nord CE 3 will be introduced as a successor to the OnePlus Nord CE 2.
OnePlus may soon expand its affordable smartphone series Nord CE. It is being claimed that the company is going to launch the new OnePlus Nord CE 3 in July this year. As per the leaks, the OnePlus Nord CE 3 will be introduced as a successor to the OnePlus Nord CE 2. The information about the phone has also been revealed ahead of its official debut on many digital platforms. However, the company has not yet given any information regarding the same as yet.
According to a report by My Smart Price, the OnePlus Nord CE 3 is expected to launch in July alongside of OnePlus Nord 3. The tipster also has claimed about the specification of the phone as well. Scroll down to know more about the smartphone.
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According to tipster Steve Hemmerstoffer (@OnLeaks), the OnePlus CE 3 will come with a display with 120Hz refresh rate, under which the user will be able to have a high definition display quality while playing videos. The handset is also likely to feature a 6.72 inch Full HD Plus AMOLED display. Earlier it was being said that this phone will be introduced with an IPS LCD screen. However, the confirmation is still awaited.
Leaks also suggested that the OnePlus Nord CE 3 is expected to be powered by the octa-core Snapdragon 782G processor coupled with up to 12GB of RAM and up to 256GB of inbuilt storage. The upcoming OnePlus Nord CE 3 could be equipped with three rear cameras. The phone can get a 50-megapixel Sony IMX890 primary sensor, an 8-megapixel ultra-wide-angle lens, and a 2-megapixel macro lens. The phone is expected to get a 16-megapixel sensor for selfie and video calls.
The handset is said to have an in-display fingerprint sensor, a 5000mAh battery with 80W fast charging support, dual-band Wi-Fi, 5G, 4G LTE, Bluetooth and a USB Type-C port.
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Gadgets
Vivo launches color-changing back panel smartphone V27 Pro in India, check price and specs
The Chinese smartphone manufacturer Vivo has launched its awaited color-changing back panel smartphone V27 Pro in India, along with the lower variant V27. Interested customers can purchase the handset in magic blue and noble black color
The Chinese smartphone manufacturer Vivo has launched its awaited color-changing back panel smartphone V27 Pro in India, along with the lower variant V27. Interested customers can purchase the handset in magic blue and noble black color. Pre-booking of Vivo V27 Pro has started and sales will be from March 6. The sale of Vivo V27 will start from 23 March.
As per the official details, the handset is the upgraded version of the Vivo V25 series, which was launched last year. The company has introduced the Vivo V27 Series with Android 13-based Funtouch OS 13 and MediaTek processor, under which customers will be able to access heavy applications without and lag.
Know everything about the Vivo’s Vivo V27 and V27 Pro
As per the photos shared by the company, Vivo V27 Pro and Vivo V27 come with a 3D curved screen with a refresh rate of 120Hz that offers users to have a high-definition screen experience while playing any video. It comes with a glass panel that changes color whenever some light or sun rays strike it. Both Vivo V27 Pro and Vivo V27 phones have three rear cameras, and features. The Vivo V27 Pro has a MediaTek Dimensity 8200 processor, while Vivo V27 has Dimensity 7200 5G processor. Both the chipset have been considered the advance chipset in the Indian market.
Price of Vivo’s V27 and V27 Pro
The price of 128 GB storage with 8 GB RAM of Vivo V27 Pro is Rs 37,999. At the same time, the price of 256 GB storage with 8 GB RAM has been kept at Rs 39,999. The 256 GB storage variant with the phone’s 12 GB RAM is priced at Rs 42,999. The price of 128 GB storage with 8 GB RAM of Vivo V27 has been priced at Rs 32,999 and 256 GB storage with 12 GB RAM has been priced at Rs 36,999.
The leading smartphone manufacturer Samsung recently launched the Galaxy S23 series in India, since then, the handsets became the talk of the time. Now the company is all set to attract more customers as it has decided to launch an affordable variant of Samsung Galaxy S23 FE in the country.
Ahead of the official launch, many information such as specs, design leaked on digital platforms, claiming the handset might come with the latest processor with a 120 Hz AMOLE display that will allow users to have a high-definition experience while playing videos or using the phone. As per the leaks, the phone could be equipped with a flagship chipset launched by Qualcomm last year. However, the South Korean tech giant hasn’t revealed anything regarding the same as of now. Not even the price and launch date.
Once launched, interested customers can purchase the smartphone from the company’s authorized store. If one wants it at an additional discount, they can purchase the phone from the e-commerce giant Amazon or Flipkart.
Know everything about Samsung Galaxy S21 FE
Tipster Connor (@OreXda) claims that the Samsung Galaxy S23 FE will be powered by the Snapdragon 8+ Gen 1 processor. It is the second most powerful chipset from Qualcomm after Snapdragon 8 Gen 2. A lot of flagship phones of this year shared the with same Snapdragon 8 Gen 1 such as OnePlus 11R, Xiaomi 12S Ultra, Asus Zenfone 9, Samsung Galaxy Z Flip 4, and Oppo Find N2 among others.
It said that the upcoming Samsung Galaxy S21 FE might replace the company’s feature-loaded smartphone Galaxy A74. It is expected that the company likely to launch the S21 FE at a similar price as A74.
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