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Cryopreservation – Dr. Hrishikesh Pai

Cryopreservation: Cryo-preservation is a technique that uses carbon dioxide or liquid nitrogen to preserve organelles, cells, tissues, organs, or any other biological structures that are prone to damage due to unregulated chemical kinetics.

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Cryopreservation

Cryopreservation: Cryo-preservation is a technique that uses carbon dioxide or liquid nitrogen to preserve organelles, cells, tissues, organs, or any other biological structures that are prone to damage due to unregulated chemical kinetics.

The chemicals and enzymes stop acting on the biological structures at extremely low temperatures.

Cryoprotectants are used to coat the matter to be frozen to avoid damage by the ice crystals that form at low temperatures.

IVF specialists use this technique to preserve semen, embryos, oocytes, and any other matter important for future reproduction in the case of a patient probably who has cancer or any other detrimental medical condition.

Dr. Hrishikesh Pai, an eminent IVF specialist in Mumbai, can be consulted to solve your predicament.

Dr. Pai is backed by his career panning for 4 decades and has the reputation of maximum success in the number of IVF he has carried out so far.

Not only is he an IVF specialist, but he is also a pioneering force in the field of ART. He has set up centers all over India under the following names: Bloom IVF center, Budget fertility center, and Babies and Us.

You can contact Dr. Hrishikesh Pai through the portals of clinicspot.com, practo.com. lybrate, justdial.com, and many other well-known portals.

Natural cryopreservation:

All of us know that bears, frogs, and many other species hibernate during the winters. What exactly is going on in these species of animals when they are in hibernation mode.

Research shows that when the water bears survive the winters, they are basically surviving the freezing by replacing their internal water with sugar trehalose, preventing it from crystallization that damages the cell membranes.

Wood frogs can also survive the freezing of their blood and other tissues because they can store urea in their tissues, and liver glycogen is converted to large quantities of glucose. A combination of urea and glucose acts as cryoprotectants. This limits the ice that forms and reduces the osmotic shrinkage of the cells.

This study formed the basis of cryopreservation of human organs, cells, tissues, etc.

Also Read: Hair loss, treatments, and transplant- Dr. Harikiran Chekuri

It was in 1954 that cryopreservation was first applied to human materials. It resulted in the 3 pregnancies from insemination using frozen sperm.

The process of slow programmable freezing:

Slow Programmable freezing is the process in which the freezing is controlled by cooling the cells at -196o C over several hours.

This technique allows sufficient water to leave the cell, reducing the number of ice crystals formed.

This technique resulted in the first successful human frozen embryo birth in 1984.

Since then, gradual cooling has been used to freeze, thaw and freeze again in liquid nitrogen.

This is the process of cryopreservation. The materials used as cryoprotectants are glycerol and dimethyl sulfoxide.

Several studies indicate that IVF using frozen embryos and eggs gives better results than fresh embryos and eggs.

Preserving Embryos:

When the process of IVF has resulted in more than 1 viable embryo, it is frozen for further use if needed.

Studies have been carried out to see if the children born of frozen embryos are different from those born naturally. They do not have any birth deformities or developed abnormalities.

Ovarian tissue preservation:

Women opt for cryopreservation of ovarian tissue under 2 circumstances.

1. is that she is battling cancer and wants to preserve her reproductive function

2. She is planning for late pregnancy and wants to preserve her reproductive function.

The surgeon will extract a part of the ovary and send it for cryopreservation.

When the patient is ready or capable of conceiving, the ovarian tissue is thawed and planted near the fallopian tube, where it starts producing new eggs allowing normal conception.

Also Read: What are the causes of recurring miscarriages? Can PIGT help?

Oocyte preservation:

Oocyte preservation is where the eggs are extracted, frozen, and stored for later use. The eggs can be thawed, fertilized, and planted in the uterus as embryos when required.

Preserving Semen:

Once the semen is preserved using cryopreservation, it can be successfully used indefinitely.

It can be used for sperm donation or for men undergoing vasectomy or cancer therapy.

Testicular tissue:

Cryopreservation of immature testicular tissue is in the developing stages to avail reproduction in young boys who might be undergoing gonadotoxic therapy.

Also Read: What are the chances of twins with IVF?

Conclusion:

Dr. Hrishikesh Pai has never shied away from adopting and mastering new technological advancements, and it is the precise reason he has a successful reputation.

Please consult him without hesitation for your condition that may need you to resort to cryopreservation.

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Top SUVs Under ₹50 Lakh in 2025: How Ford Endeavour Compares Against Its Rivals

The new-generation Endeavour (known globally as the Everest) is carving out a niche, not by being the flashiest, but by doubling down on what made it iconic: rugged capability, unmatched comfort, and Ford’s driver-first DNA.

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Walk into any premium SUV showroom in 2025, and you’ll see one thing in common, everyone is trying to be the next Fortuner killer. From the Toyota Fortuner’s legendary reliability to the MG Gloster’s tech-laden interior, the segment under ₹50 lakh is fiercely competitive. But the one name that’s quietly making a storming comeback in India is the Ford Endeavour.

Re-entering the market through CBU or CKD routes, the new-generation Endeavour (also known globally as the Everest) is carving out a niche, not by being the flashiest, but by doubling down on what made it iconic: rugged capability, unmatched comfort, and Ford’s driver-first DNA.

Let’s break down how it stacks up against the competition, and more importantly, whether it’s worth your money in 2025.

The Ford Endeavour’s Unique Positioning

While rivals like the Fortuner and Gloster come packed with features and road presence, the Endeavour plays a different game. It doesn’t try to win on badge or sheer size, it wins on refinement, handling, and the premium SUV experience. The Endeavour doesn’t scream for attention. It delivers an understated yet powerful drive, much like an executive sedan disguised as an off-roader.

What the Endeavour Offers That Rivals Often Miss

  • True 4×4 DNA: Full-time 4WD with terrain response system and low-range gearing, something even the Fortuner reserves for its pricier variants.
  • Road Comfort: The Endeavour’s suspension setup feels tuned for Indian roads, absorbing undulations far better than stiffer rivals like the Fortuner.
  • Interior Refinement: The global model brings in a vertical 12-inch touchscreen, digital driver display, and soft-touch materials, giving the cabin a genuinely modern and plush feel.
  • Diesel Performance: While most competitors are shifting to petrol or hybrid powertrains, the new Endeavour sticks to a torquey 2.0-litre Bi-Turbo diesel, offering strong performance without the complexity of hybrid systems.

Rival Comparison Snapshot

SUVEngine OptionsKey StrengthWeakness
Ford Endeavour2.0 Bi-Turbo DieselBalanced comfort + off-road abilityLimited dealer support (CBU/CKD pricing)
Toyota Fortuner2.8 Diesel / 4×4 ATReliability & resaleStiff ride, dated tech
MG Gloster2.0 Twin Turbo DieselFeatures & spaceLacks brand trust, sluggish gearbox
Jeep Meridian2.0 DieselPremium build, great handlingLess spacious third row
Hyundai Tucson (AWD)2.0 DieselUrban refinementNot a true off-roader
Skoda Kodiaq2.0 TSI PetrolEuro styling, superb ridePetrol-only, no low-range gearing

The Pricing Puzzle: Is the Endeavour Worth It?

Ford’s re-entry into the Indian market via the CBU route does push the Endeavour’s price close to ₹45–48 lakh on-road, which might seem steep at first glance. But what you’re paying for is:

  • Global-spec build quality
  • Proven diesel engine
  • Feature-loaded cabin
  • True off-road capability

Compare that to a ₹52–55 lakh Fortuner GR-S or a ₹45 lakh MG Gloster Savvy 4×4, and the Endeavour doesn’t look overpriced, it looks well-positioned.

Who Should Consider the New Endeavour?

Buy if:

  • You want a full-size SUV with authentic off-road ability and refined road manners.
  • You value driving comfort as much as street presence.
  • You’re okay with slightly higher entry cost for better overall experience.

Skip if:

  • You need wide dealership and service coverage in Tier-2 or Tier-3 cities.
  • You prefer petrol or hybrid options.
  • You’re focused on resale value above all else.

Final Word: A Quiet Comeback with Loud Value

The Ford Endeavour in 2025 doesn’t try to beat its rivals on paper alone. It wins by delivering what many SUVs forget, a genuine sense of command on the road, a plush yet practical interior, and real-world 4×4 ability, all wrapped in a design that feels premium but not pretentious. And if a new specimen in not in your books, aused Ford Endeavour just might be what fits the bill!

If you’re looking at top second hand SUVs under ₹50 lakh, and you want something that drives like it belongs above that price tag, the Endeavour deserves more than a second look. In fact, it may just be the most complete SUV in this space, if you know what you’re buying.

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7 Reasons Parents Should Stay in Touch With Their Child’s Preschool Teacher

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Preschool is your child’s first real experience with a structured learning environment, and it’s a big step. At this early stage, your involvement as a parent plays a vital role in helping your child adjust, thrive, and build confidence. One of the most effective ways to stay involved? Maintaining regular communication with your child’s preschool teacher.

Many parents believe their role is limited to drop-offs, pick-ups, and paying fees. But staying connected with your child’s teacher goes far beyond logistics. It builds trust, strengthens learning, and ensures your child gets the support they need both at school and at home. In this blog, we will discuss seven reasons parents should talk to their preschool teachers from time to time.

7 Reasons Parents Should be in Touch with Their Kid’s Preschool Teacher

Here are seven compelling reasons why you should make that connection a priority.

  • Gain Insight into Your Child’s Development

Teachers spend several hours a day with your child, observing their learning habits, social skills, and emotional responses in real-time. Regular check-ins with the teacher can provide valuable insights into areas where your child is thriving and where they may need a little extra support.

These early signs are especially useful when you’re planning for next steps, like Senior KG admission, where readiness in both academic and emotional areas matters.

  • Create a Consistent Support System

Children feel more secure when parents and teachers are on the same page. When your child sees that you and their teacher are in sync, it reinforces consistency in discipline, expectations, routines, and praise.

Whether it’s toilet training, sharing toys, or learning phonics, your child benefits from a united message across school and home.

  • Address Concerns Early

Behavioural changes, learning delays, or emotional challenges can show up subtly at first. If you maintain open lines of communication with your child’s teacher, it becomes easier to identify and address these concerns promptly.

The earlier you address a concern, whether it’s speech delays, separation anxiety, or difficulty making friends, the easier it is to find solutions and build confidence.

  • Stay Informed About Classroom Activities

Preschools are full of activities, art projects, story time, group games, theme days, and more. By staying in touch with your child’s teacher, you’ll know what’s happening in class and can follow up at home.

This also helps you ask the right questions at the end of the day. Instead of the usual “How was school?”, you can say, “I heard you did a puppet show today, what was your favourite part?”

This kind of engagement boosts memory, conversation skills, and your child’s enthusiasm for learning.

  • Support Skill Building at Home

Teachers can guide you on how to support your child’s learning journey outside the classroom. They may suggest:

  • Fine motor skill exercises (like cutting or beading)
  • Language-building games
  • Counting or shape recognition through play
  • Reading recommendations

This is especially helpful for parents preparing their child for upcoming transitions like Senior KG admission where stronger foundational skills are expected.

  • Build Trust and Ease Anxiety

Children pick up on your attitude. When they see you have a warm, respectful relationship with their teacher, they are more likely to feel comfortable, safe, and positive about school.

It also helps ease separation anxiety. If your child knows that “Mom talks to my teacher” or “Dad knows what I did at school,” they’ll feel reassured and more secure about being away from home.

  • Be a More Active Participant in Your Child’s Education

Staying in touch doesn’t just mean attending the annual parent-teacher meeting. It means showing interest throughout the year, asking questions, offering feedback, and showing up when needed.

Many of the best preschools in Nagpur encourage parent involvement through classroom visits, online updates, event participation, or parent-teacher communication apps. Taking part in these activities shows your child that their education matters and that you are part of it.

Final Thought

Building a strong relationship with your child’s preschool teacher is one of the simplest yet most impactful things you can do. It creates a powerful partnership that supports your child’s growth, learning, and emotional well-being.

Preschools like EuroKids understand this balance. Their approach includes not just structured early learning but also strong parent engagement, helping families work hand in hand to support each child’s journey from day one.

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Happy Navratri 2025: Wishes, messages, quotes, greetings, images, and whatsApp greetings

Celebrate Navratri 2025 with heartfelt wishes, messages, quotes, and WhatsApp greetings. Share the joy of the nine nights of devotion to Maa Durga, spread positivity, and bless your loved ones with happiness, strength, and prosperity this festive season.

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Navratri Wishes 2025

Navratri 2025, starting on September 22, is a nine-night festival dedicated to Maa Durga, celebrating the victory of good over evil. Across India and around the world, devotees mark the occasion with prayers, fasting, music, dance, and community gatherings. The festival emphasizes devotion, courage, and inner strength, and is a time to share blessings with loved ones through heartfelt Navratri wishes.

Unlike large-scale celebrations in India, many households and communities celebrate in more intimate settings, decorating homes with diyas, offering prayers at temples, and organizing dandiya nights and devotional gatherings. Traditional foods and vrat-friendly recipes are also an integral part of the celebration.

Here’s a collection of Happy Navratri wishes you can share with friends, family, and colleagues:

Wishes to Share During Navratri:

  • Wishing you a Navratri filled with devotion, joy, and prosperity.
  • May the nine nights bring peace to your home and happiness to your heart.
  • Let’s celebrate the spirit of Navratri with prayers, music, and love.
  • May Goddess Durga bless you with strength to face every challenge.
  • Wishing you health, harmony, and happiness this Navratri.
  • May these nine nights light up your life with positivity.
  • Sending warm Navratri wishes from my family to yours.
  • May every dance step and prayer you offer reach Maa Durga’s blessings.
  • Here’s to a Navratri that feels bright, peaceful, and full of grace.
  • May this festive season give you courage and clarity.

Happy Navratri Quotes:

  • May your prayers during these nine nights bring success and harmony.
  • Celebrate the spirit of Navratri with a heart full of gratitude.
  • Wishing you good health, prosperity, and endless joy this Navratri.
  • Let the divine energy of Durga guide your path this festive season.
  • May Goddess Durga empower you with strength, wisdom, and courage this Navratri and always.
  • Let us celebrate the triumph of good over evil. Happy Navratri to you and your loved ones.
  • May the colors of Navratri brighten your life with happiness, health, and prosperity.
  • On this auspicious occasion, may Maa Durga fulfill all your wishes and bless your home with peace.

Messages to Share on WhatsApp and Social Media:

  • Happy Navratri! May Maa Durga guide you toward wisdom and strength.
  • The nine nights remind us that patience and devotion bring results.
  • Celebrate Navratri with faith in your heart and kindness in your actions.
  • May you find joy in the small rituals and blessings in every prayer.
  • Wishing you courage to overcome negativity, just like Durga did.
  • Navratri is not only about fasting — it’s about feeding your soul with positivity.
  • May this Navratri open doors of success and peace for you.
  • Sending warm wishes across the miles this festive season.

Happy Navratri 2025 Greetings:

  • Remember: every night of Navratri is a chance to start fresh.
  • Happy Navratri 2025! Celebrate with love, and let blessings surround you.
  • May Maa Durga fill your home with peace and happiness this Navratri.
  • Wishing you nine nights of devotion, joy, and togetherness.
  • May the blessings of Navratri bring love and light into your life.
  • Happy Navratri! Let every day be a step toward positivity.
  • May this festive season strengthen bonds with family and friends.

Navratri 2025 Quotes and Inspiration:

  • “Navratri is not only a festival, it’s a reminder that good always wins.”
  • “Nine nights, nine forms, infinite blessings.”
  • “Strength is not given, it is awakened — just like the spirit of Durga.”
  • “Dance, devotion, and discipline — the rhythm of Navratri.”
  • “Every prayer during Navratri is a step closer to peace.”

This Navratri, let devotion, love, and positivity fill every home. Share these Navratri wishes, quotes, and messages to spread blessings and joy with friends and family.

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