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In caste-ridden India, genetic isolation may be harmful to health

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[vc_row][vc_column][vc_column_text]~By Dinesh C Sharma

The occurrence of genetic diseases in certain subpopulations in India and other countries in South Asia is well known. Indian scientists now suspect that this could be due to genetic isolation caused by endogamous marriages over generations.

Endogamous marriages – meaning people marrying within a subpopulation based on caste, gotra, language or culture – lead to reduced genetic variation. They are different from marriages among close relatives (consanguineous marriages) – which is also prevalent in parts of South India.   

In genetics, the phenomenon of a small number of ancestors giving rise to many descendants is known as ‘founder event’ or a population bottleneck. A study of anthropologically different subpopulations in South Asia has revealed that many of them are a result of strong ‘founder events’. In each of such groups, large stretches of DNA originates from a common founder in the last about 100 generations.

There is less genetic variation because these subpopulations have lived in genetic isolation despite co-living with other groups for centuries due to various factors including caste. Such populations are vulnerable to recessive genetic diseases (in which an offspring gets disease-causing genes from both parents). This risk, researchers say, is very different from that due to marriages among close relatives.

The study, led by scientists at Hyderabad-based Centre for Cellular and Molecular Biology (CCMB), appeared in scientific journal Nature Genetics on Tuesday. Scientists analysed samples from over 2800 individuals from over 275 distinct South Asian populations belonging to various social and linguistic groups from India, Pakistan, Nepal, Sri Lanka, and Bangladesh. They developed an algorithm to quantify impact of ‘founder events’ in each group based on stretches in DNA shared from a common founder over generations.

“We found that 81 out of 263 unique South Asian groups, including 14 groups with estimated census sizes of over a million, have a strong founder event,” said Dr Kumarasamy Thangaraj, who led the study along with David Reich of Harvard Medical School.  These large population groups with founder events include Gujjar (Jammu & Kashmir), Baniyas (UP), Pattapu kapu (AP), Vadde (AP), Yadav (Puducherry), Kashtriya Aqnikula (AP), Naga (Nagaland), Kumhar (UP), Reddy (Telangana), Kallar (TN), Brahmin Manipuri (Manipur), Arunthathiyar (TN) and Vysya (Telangana).

Researchers have highlighted the problem through example of Vysya population which has size of more than 3 million. The Vysyas have about 100-fold higher rate of a metabolic disorder called Butyrylcholinesterase (BChE) deficiency compared to other groups. Such people are highly sensitive to anesthesia administered prior to surgery.

“The next step would be to identify specific recessive diseases among various subpopulations and identify genes responsible for them,” Dr Thangaraj told India Science Wire. The research can have significant public health applications, as has been done with some population groups like Ashkenazi Jews, Finns, Amish, Hutterites, Sardinians, and French Canadians in the West. Once recessive genetic diseases specific to different groups are mapped, preventive steps like prenatal testing, premarital counseling and screening can help decrease burden of such diseases in communities.

The team of researchers came from Columbia University; Broad Institute of Harvard and Massachusetts Institute of Technology; Manipal University; Centre for Human Genetics, Bangalore; Mangalore University; Fetal Care Research Foundation, Chennai; Amity University, Noida; Genome Foundation, Hyderabad; Anthropological Survey of India, Kolkata; and Birbal Sahani Institute of Paleosciences, Lucknow. The research was funded by Department of Science and Technology (DST), Department of Biotechnology (DBT), Indian Council of Medical Research (ICMR). (India Science Wire)[/vc_column_text][/vc_column][/vc_row]

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OnePlus India CEO Robin Liu steps down, shutdown rumours resurface

OnePlus India confirms business continuity after CEO Robin Liu’s resignation sparks shutdown rumours online.

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The resignation of Robin Liu as India CEO of OnePlus has triggered fresh speculation online about the company’s future, even as the firm has firmly denied any plans to shut down operations.

Liu will step down from his role effective March 31, 2026. His exit comes months after he publicly dismissed similar rumours about the company withdrawing from certain markets.

Google searches spike after leadership exit

Following news of Liu’s departure, search trends for terms like “OnePlus shutdown”, “OnePlus shutting down”, and “OnePlus India shutdown” saw a noticeable surge, indicating rising public concern.

However, OnePlus India clarified that there is no change in its business operations and dismissed the shutdown claims as misinformation.

In a public statement, Liu said the company is “operating as usual” and urged stakeholders to rely on official sources rather than unverified reports. He reiterated that claims about the company shutting down are false.

Company says operations remain unchanged

The company stated that Liu’s decision to step down was due to personal reasons and not linked to any strategic withdrawal or operational challenges in India.

OnePlus further emphasized that its India business continues normally, with no immediate changes expected in its strategy or market presence.

Restructuring within OPPO group

Industry observers suggest Liu’s exit may be part of a broader restructuring within the OPPO group, which owns OnePlus.

The restructuring is believed to focus on streamlining operations, reducing costs, and accelerating product development amid challenges such as rising component costs and supply constraints.

Reports also indicate that OnePlus experienced a decline in shipments in 2025, which may have contributed to internal changes.

Reports hint at global strategy shift

According to a report by 9to5Google, the company may scale back its presence in some global markets, including parts of Europe, as early as April 2026.

At the same time, OnePlus is reportedly planning to strengthen its focus on India and expand further into the mid-range smartphone segment.

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Oppo K14 5G launched in India with 7000mAh battery, starts at Rs 17,999

Oppo has launched the K14 5G in India with a 7000mAh battery, fast charging and durability features, starting at Rs 17,999.

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oppo K14 5G

Oppo has launched its latest mid-range smartphone, the K14 5G, in India, positioning it as an “endurance powerhouse” with a strong focus on battery life, smooth performance and long-term reliability.

The smartphone starts at Rs 17,999 for the 6GB + 128GB variant, while the 6GB + 256GB and 8GB + 256GB models are priced at Rs 19,999 and Rs 21,999 respectively. It will be available for purchase starting March 20 via Flipkart and the company’s official online store. Buyers can also avail an instant discount of up to Rs 1,000 along with no-cost EMI options for up to three months.

Focus on battery life and endurance

A key highlight of the Oppo K14 5G is its 7000mAh battery, designed to support extended daily usage without frequent charging. The company claims the device can deliver up to 738.8 hours of standby time. It also supports long usage across activities such as voice calls, video streaming, navigation and messaging.

The device comes with 45W fast charging, which can charge the battery from 1 percent to 37 percent in around 30 minutes, with a full charge taking about 92 minutes. Oppo says the battery is engineered to maintain durability for up to five years. Reverse wired charging is also supported for added convenience.

Built for durability and everyday use

The smartphone is designed with durability in mind, featuring SGS 5-star certification and MIL-STD-810H military-grade testing. It has undergone multiple drop tests and transportation shock testing to ensure resistance against accidental falls and rough usage conditions.

The device also carries IP66, IP68 and IP69 ratings, offering protection against dust, water immersion and high-pressure water exposure. Additional features like water-repellent camera coating and glove and splash touch support further enhance usability in different environments.

Display and design

The Oppo K14 5G features a 6.75-inch display with a 120Hz refresh rate and brightness of up to 1125 nits in high brightness mode. It is available in three colour options — Icy Blue, Prism Violet and Prism White — with a matte finish and subtle reflective design elements.

Performance and cooling

Powered by the MediaTek Dimensity 6300 chipset, the smartphone is designed to handle everyday tasks such as browsing, streaming and multitasking efficiently. It runs on ColorOS 15, which includes system optimisation features aimed at maintaining smooth performance over time.

To manage heat during extended usage, the device includes a vapor chamber cooling system with graphite layers for improved thermal management. This helps maintain stable performance during gaming and heavy usage.

Camera and AI features

The smartphone is equipped with a 50MP main camera, supported by a 2MP monochrome sensor, along with an 8MP front camera. It offers AI-powered features such as portrait retouching, AI eraser, AI clarity enhancement and dual-view video recording.

These tools are designed to improve image quality, assist in editing and enhance overall photography experience for users.

Availability and after-sales support

The Oppo K14 5G will be available starting March 20 with launch offers including discounts and EMI options. The company is also offering a 30-day inspection and replacement policy in case of manufacturing defects, supported by its nationwide service network.

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OnePlus Freedom Sale 2026 brings discounts on 15, 15R, 13, Nord 5 and tablets

OnePlus Freedom Sale 2026 begins Jan 16 with discounts on phones, tablets, and audio products across online and offline stores.

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OnePlus has announced its Freedom Sale, offering discounts on smartphones, tablets, and audio products across online and offline platforms. The deals include the recently launched OnePlus 15 series, Nord lineup, Buds audio devices, and other gadgets.

When and where to shop

The OnePlus Freedom Sale starts on Jan. 16 and will run both online and offline. Shoppers can purchase smartphones through OnePlus.in, OnePlus Experience Stores, Amazon, as well as offline retailers including Croma, Reliance Digital, Vijay Sales, and others. Tablets are available on Flipkart during the sale period.

Discounts on OnePlus smartphones

  • OnePlus 15: Launched at Rs 72,999, buyers can get an instant Rs 4,000 discount, lowering the effective price to Rs 68,999. Additional benefits include six months of no-cost EMI and a bundled OnePlus Nord Buds 3.
  • OnePlus 13: Originally priced at Rs 69,999, the phone receives an Rs 8,000 price drop, plus a bank discount of Rs 4,000, bringing the price down to Rs 57,999.
  • OnePlus 15R: Listed at Rs 47,999, buyers can avail Rs 3,000 off until Jan 26. After the date, the effective price is Rs 45,999.
  • OnePlus 13R: Launched at Rs 42,999, this device gets up to Rs 6,000 price cut and an additional Rs 1,000 bank discount.

Discounts on OnePlus tablets

  • OnePlus Pad 2: Rs 2,000 instant bank discount reduces the price to Rs 34,999.
  • OnePlus Pad 3: Eligible for a Rs 3,000 instant discount, making the price Rs 44,999. Purchases until Jan 26 include a free Stylo 2 stylus.
  • OnePlus Pad Go 2: Rs 1,000 price drop plus Rs 2,000 bank discount, now Rs 23,999.
  • OnePlus Pad Go: Price reduced to Rs 13,999 after Rs 3,000 cut and Rs 1,000 bank discount.
  • OnePlus Pad Lite: Available for Rs 11,999 after a Rs 2,000 price drop and Rs 2,000 bank discount.

Audio devices on offer

  • OnePlus Buds 4: Rs 700 price cut with Rs 300 bank discount, bringing the effective price to Rs 4,999.
  • OnePlus Buds Pro 3: Now Rs 9,999 after Rs 1,000 price drop and Rs 1,000 bank discount. No-cost EMI options are available for both Buds 4 and Buds Pro 3.

Additional discounts are also applicable to the Nord Buds series — including Nord Buds 3, Nord Buds 3 Pro, and Nord Buds 3R — and neckband devices such as Bullets Wireless Z2 ANC and Bullets Wireless Z3.

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