Gadgets
Nobel for medicine to researchers for cancer treatment breakthrough
James P Allison of the US and Tasuku Honjo of Japan were today (Monday, October 1) awarded the 2018 Nobel Prize in Physiology or Medicine for discovery of a type of cancer treatment that harnesses a person’s own immune system, revolutionising the treatment of cancer .
“By stimulating the inherent ability of our immune system to attack tumor cells this year’s Nobel Laureates have established an entirely new principle for cancer therapy,” the Nobel Prize Foundation said in a statement.
“Allison and Honjo showed how different strategies for inhibiting the brakes on the immune system can be used in the treatment of cancer,” the Nobel Assembly at Sweden’s Karolinska Institute said in a statement on Monday, jointly awarding the prize of 9 million Swedish crowns (€870,000, $1 million) to the two scientists.
This year’s #NobelPrize constitutes a landmark in our fight against cancer. The discovery made by the two Medicine Laureates takes advantage of the immune system’s ability to attack cancer cells by releasing the brakes on immune cells. pic.twitter.com/2mppP3NT19
— The Nobel Prize (@NobelPrize) October 1, 2018
Medicine is the first of the Nobel Prizes awarded each year. The prizes for achievements in science, literature and peace were created in accordance with the will of dynamite inventor and businessman Alfred Nobel, and have been awarded since 1901.
The literature prize will not be handed out this year after the awarding body was hit by a sexual misconduct scandal.
2018 #NobelPrize laureate James P. Allison studied a protein that functions as a brake on the immune system. He realised the potential of releasing the brake and unleashing our immune cells to attack tumours. He developed this concept into a new approach for treating patients. pic.twitter.com/MWYS3DnD8n
— The Nobel Prize (@NobelPrize) October 1, 2018
The two medicine laureates studied proteins that prevent the body and its main immune cells, known as T-cells, from attacking tumour cells effectively.
Allison, who is a professor at the University of Texas MD Anderson Cancer Center, Houston, was studying a protein called CTLA-4 that inhibits a person’s immune system by putting the brakes on the actions of T cells. He realized that if he could release that “brake”, the immune system would wreak havoc on tumours. Allison developed this idea into a new type of cancer treatment.
Tasuku Honjo, awarded the 2018 #NobelPrize, discovered a protein on immune cells and revealed that it also operates as a brake, but with a different mechanism of action. Therapies based on his discovery proved to be strikingly effective in the fight against cancer. pic.twitter.com/3yn2RCtr6W
— The Nobel Prize (@NobelPrize) October 1, 2018
Meanwhile, Honjo, who is now a professor at Kyoto University in Japan, discovered a similar immune system-braking protein. Called PD-1, this protein, he found, functions as a T-cell brake but via a different mechanism than CTLA-4 uses. Honjo’s research led to the clinical development of treating cancer patients by targeting that protein.
Whereas both proteins have proven to be effective targets for treating different types of cancer, PD-1 has shown stronger results for the so-called immune checkpoint therapy, according to the Nobel Prize Foundation. Targeting PD-1 has shown positive results in treating lung cancer, renal cancer, lymphoma and melanoma. And more recently, scientists have found that combining the two targets can be even more effective in cancer treatment, particularly in combating melanoma.
Honjo and Allison will split the Nobel prize amount of 9 million in Swedish krona, or $1.01 million.
Phones & gadgets
Apple launches iPhone 15 series, India price, features, availability
The iPhone 15 series will be available in India from September 22 but iPhone lovers can also pre-order, starting from September 15 onwards.
Apple launched its most anticipated iPhone 15 series, including the iPhone 15, iPhone 15 Plus, iPhone 15 Pro and iPhone 15 Pro Max during the Wonderlust event globally on September 12 night.
The iPhone 15 series will be available in India from September 22 but iPhone lovers can also pre-order, starting from September 15 onwards.
People can buy a new iPhone 15 or upgrade it to the old one. There are five colours available for the people.
According to reports, Apple has been manufacturing the iPhone 15 series in India and China. Apple has moved 7% of its iPhone production to India. Previously, India was not making the newest models. The Centre’s production-linked incentive (PLI) scheme for smartphones played a part in Apple moving its production to India.
The new iPhone 15 has been launched with the same starting price as its prototype, the iPhone 14. The 128GB variant is priced at Rs 79,900, while the 256GB variant costs Rs 89,900. For people who need more storage, the 512GB variant is available for Rs 1,09,900.
This latest iPhone series puffs a 6.1-inch display and comes in five different colours which are pink, yellow, green, blue, and black. While the design remains the same as the previous models, the iPhone 15 features a dynamic island notch instead of the usual notch, which was highly popular among the iPhone 14 Pro phones.
The camera part of the iPhone series has undergone significant upgrades, the new iPhone 15, with an enhanced 48-megapixel primary sensor replaces the 12-megapixel dual camera system which was available in the previous iPhone 14. This significant improvement promises better low-light photography and portrait shots.
The tech giant announced that the iPhone 15 has an all-day battery life, making it more convenient for users to go about their daily activities without worrying about their phone’s battery.
The iPhone 15 Pro models feature a lighter body and thinner bezels. The new AirPods Pro with USB-C charging case will support Lossless Audio with Apple Vision Pro.
Additionally, the iPhone 15 is powered by Apple’s A16 bionic processor, an upgrade from the A15 bionic chipset used in the previous iPhone 14 and iPhone 14 Plus models. The Pro models had the faster and better A16 chip, but now this feature is available in all iPhone 15 models.
The USB-C port on the standard iPhone 15 and iPhone 15 Plus remain limited to lightning speeds up to 480 Mbps. The iPhone 15 Pro and iPhone 15 Pro Max support USB 3 speeds up to 10 Gbps. People will need to buy a separate 1-meter Thunderbolt 4 Pro cable for Rs 5,724 or Rs 10,701 for the 1.8-meter cable to support faster speeds.
The dynamic island notch feature, which can adjust its size according to notifications, was widely discussed before the launch of the iPhone 15. This unique feature can now be available in all models of the phone.
Another important feature of the iPhone 15 is the shift to the USB Type C charging port. Apple has abandoned the lightning port in favour of the more commonly used USB Type C charging port. This means, there is no longer a need for a special iPhone charging cable to be carried around everywhere you go.
Gadgets
OnePlus Onam Offers: Discounts, cashbacks, exchange offers, check details
ICICI customers can avail an extra Rs 500 discount through Net Banking on OnePlus 11 5G and OnePlus 11 5G Marble Odyssey purchases from OnePlus.in till August 31, 2023.
OnePlus, one of the leading global technology brands, has announced a captivating lineup of products to celebrate the festive spirit of Onam. According to reports, OnePlus 11 5G and OnePlus 11R 5G come with exclusive savings and exchange bonuses during this festive season.
OnePlus Ensemble Bundle: The technology brand has introduced a curated collection of OnePlus 11 5G, OnePlus Pad and Buds Pro 2. Following an instant discount of Rs 4000 through ICICI Bank and OneCard, prices began at Rs 1,07,997. Furthermore, customers of Axis Bank, Citi, HDFC Bank, ICICI Bank, SBI Cards, and OneCard can benefit from up to a 24-month No Cost EMI.
OnePlus 11 5G: ICICI customers can avail an extra Rs 500 discount through Net Banking on OnePlus 11 5G and OnePlus 11 5G Marble Odyssey purchases from OnePlus.in till August 31, 2023. Meanwhile, OneCard users can also take an instant Rs 2000 bank discount on the same devices exclusively till August 31. Purchasers also have the opportunity to unlock an additional exchange bonus worth Rs 6000 and Rs 10000 on the OnePlus 11 5G and OnePlus 11 5G Marble Odyssey.
OnePlus Nord 3 and Nord CE 3: ICICI Bank Credit Card, Credit EMI and Debit Card EMI users can get an instant discount of Rs 1000 on purchase of the OnePlus Nord 3 5G. The offer is valid till August 31. Furthermore, OneCard credit card and EMI users can also enjoy an instant discount of Rs 1000 on the purchase of the OnePlus Nord 3 5G.
Moreover, OnePlus Nord CE 3 5G purchase facilitates a Rs 1000 instant discount on Axis Bank and Citi Credit and Debit Cards through EMI transactions and all OneCard transactions. This particular offer will be valid from September 1, 2023. Reportedly, this offer also holds eligibility for No Cost EMI with Axis Bank, Citi, HDFC Bank, ICICI Bank, SBI cards and OneCard for six months.
vivo V23 Overview
Looking for a new smartphone that blends design with performance and utility? Launched in January 2022, vivo V23 delivers a premium experience, both in terms of hardware and software, while keeping the cost in check. If you want a fast vivo 5G mobile with a professional-quality camera, vivo V23 can be a good choice.
vivo V23 Price and Specifications
The price for the base variant of vivo V23 (Sunshine Gold, 4GB RAM, 64GB storage) is Rs. 29,990 in the Indian market.
1. Performance
vivo V23 has the efficient MediaTek Dimensity 920 chipset under the hood. Coupled with 8GB RAM, the processor allows you to breeze through heavy gaming sessions, HD streaming, and multitasking. Since the processor goes through a 6 nm fabrication process, it can deliver a benchmark performance without draining the battery too much. The handset runs on Funtouch OS (based on Android 12) that offers a seamless and intuitive performance.
2. Design
vivo V23 weighs just 179g and is only 7.3mm thick, making it super easy to fit in your pocket. The mineral glass back gives the phone a classy, ergonomic feel, and the phone feels comfortable to operate even after long hours of usage. If you want to flaunt a unique-looking smartphone without paying too much, you should consider vivo V23.
3. Battery
A smartphone is only as good as its battery. vivo V23 seems to have taken this advice to heart – it packs a stunning 4,200 mAh battery that can last all day on a full charge. Additionally, the phone supports 44W quick charging that can charge the battery from 0 to 68% in only 30 minutes. If battery life is your main concern, vivo V23 can offer a promising solution.
4. Connectivity
The vivo V23 supports the latest 5G and 4G bands along with Wi-Fi 5, ensuring blazing-fast internet speeds. You also get Bluetooth 5.2 and a USB Type-C port allowing easy and seamless data transfer between devices. For uninterrupted and accurate navigation, the phone includes GPS with A-GPS and GLONASS. You also get support for a dual nano SIM, so you can use two numbers in a single smartphone.
5. Storage
vivo V23 packs 128GB of in-built storage, allowing you to store all your apps, multimedia, games, documents, etc. on the device. The storage capacity is sufficient even for heavy users who use their handsets as a portable hard drive. vivo V23 5G comes with the support for an OTG flash drive to store more if you run out of space.
6. Camera
vivo V23 offers a triple rear camera with a 64MP primary sensor (f/1.89 aperture), an 8MP Ultra-Wide sensor (f/2.2 aperture), and a 2MP macro lens (f/2.2 aperture). The dual front camera setup comprises a 50MP primary camera (f/2.0 aperture) and an 8MP Ultra-Wide camera (f/2.28 aperture). You also get a dual LED flash (one at the front and one at the back) allowing you to capture unbelievable night shots with the utmost clarity.
7. Display
Passionate gamers and OTT binge-watchers can rejoice over vivo V23’s stunning display. The large 6.44-inch AMOLED screen with HDR 10+ supports life-like colours and brings all your favourite TV shows and movies to life. Impressively, a 91% screen-to-body ratio provides a bezel-free viewing experience. Thanks to its 90Hz refresh rate, the display is also awesome for HD gaming.
With a premium design, amazing performance, and mesmerising display, vivo V23 is a value-for-money device and a mid-range smartphone marvel. If you want a premium handset experience without paying a premium price, you should definitely check out vivo V23 5G. The phone not only offers a smooth performance but also a long battery life on a single charge. So, what are you waiting for? Get your hands on this impressive device from Bajaj Mall online and walk away with the best deals and discounts in India.
