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Blood test possible to diagnose liver fibrosis: new study

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AIIMS

By Bhavya Khullar

Doctors have long been using biopsy to diagnose liver fibrosis. A new study says it may be possible to diagnose the liver disease with a blood test in future.

Researchers at the All India Institute of Medical Science (AIIMS), New Delhi, working in collaboration with Justus Liebig University, Giessen in Germany, have identified diagnostic markers for liver fibrosis. With these markers, it will be possible to diagnose liver fibrosis from blood samples. It will make diagnosis easier to perform, non-invasive, and less prone to sampling errors, researchers say in their study published in journal Clinical and Translational Gastroenterology.

The new study has reported that patients of liver fibrosis have elevated levels of two proteins- Cathepsin L and Cathepsin B – in liver tissues as well as blood plasma, compared to healthy people. The increased levels of these two proteins open the possibility of designing a new and better diagnosis for liver disease. There is progressive increase in concentrations of the two proteins with advancement in the stages of liver cirrhosis, making them potential diagnostic tools.

The observation was first made in animals and then humans. It was seen that the two proteins are elevated in kidney, heart, and lung fibrosis, which led to the idea of testing their diagnostic relevance in liver disorder. Since the findings are based on blood samples from 51 patients, researchers have recommended studies involving larger group of patients to further validate their work.

However, an expert working in the same field pointed out that “previous studies have also reported biomarkers for liver fibrosis. The challenge is to find a marker that can differentiate between mild and severe stages of the disease in addition to distinguishing between healthy and severely ill conditions.”

Liver fibrosis is caused by several factors including alcohol consumption, viral infection, and metabolic disorders. It is also congenital in some cases. It is marked by the formation of scars and nodules in the liver, which is due to accumulation of specific proteins.

The study team included Mansi Manchanda, Prasenjit Das, Gaurav Gahlot, Ratnakar Singh, Elke Roeb, Martin Roderfeld, Siddhartha Datta Gupta, Anoop Saraya, R M Pandey and Shyam S Chauhan.(India Science Wire)

India News

Mahadev betting app founder Sourabh Chandrakar detained in Oman, India seeks extradition

Mahadev betting app founder Sourabh Chandrakar has been detained in Oman on an Interpol Red Notice, with Indian authorities pursuing his extradition in the alleged Rs 6,000 crore betting case.

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Sourabh Chandrakar

Indian authorities are working to bring back alleged Mahadev betting app founder Sourabh Chandrakar after he was detained in Oman, according to officials. Chandrakar, one of the key accused in the alleged online betting syndicate, has been held by the Royal Oman Police following an Interpol Red Notice issued at the request of Indian investigating agencies.

Officials said India is pursuing both extradition and deportation options to secure Chandrakar’s return, citing the seriousness of the charges against him.

Chandrakar detained following Interpol Red Notice

According to officials, Chandrakar, a native of Chhattisgarh in his 30s, was detained in Oman a few weeks ago based on an Interpol Red Notice issued by agencies including the Enforcement Directorate (ED) and Chhattisgarh Police.

Investigators tracking the case have also received informal inputs suggesting that Chandrakar was allegedly travelling using a passport issued by a Southeast Asian country.

Before his detention in Oman, Indian agencies had reported that Chandrakar was in Dubai. Authorities had earlier claimed that he was detained there in 2024 before being released. Officials have also stated that his alleged associate and Mahadev app co-founder Ravi Uppal later moved from Dubai to Vanuatu.

ED alleges Rs 6,000 crore betting racket

The Enforcement Directorate has described the Mahadev betting app case as a large-scale international online betting syndicate with alleged proceeds of crime estimated at around Rs 6,000 crore.

The agency has previously alleged that the investigation involves several high-ranking politicians and bureaucrats from Chhattisgarh.

According to the ED, the syndicate allegedly operated through multiple online betting platforms and domain names, including Tiger Exchange, Gold365 and Laser247. Investigators claim the operation functioned through a franchise-based network of panels and branches across India, while Chandrakar and Uppal allegedly managed its operations from Dubai.

Assets worth Rs 1,700 crore attached

In March, the ED said it had attached assets worth approximately Rs 1,700 crore linked to Chandrakar and associated entities. A significant portion of these properties is located in Dubai, including assets in the Burj Khalifa.

The agency has so far arrested 13 individuals in connection with the investigation and has named 74 entities as accused across five charge sheets filed before a special Prevention of Money Laundering Act (PMLA) court in Raipur.

The ED has also approached a court seeking to declare Chandrakar, Ravi Uppal and other accused, including Anil Agrawal alias Atul and Shubham Soni, as Fugitive Economic Offenders under the Fugitive Economic Offenders Act, 2018.

India hopeful of Chandrakar’s return

Officials expressed confidence that India would be able to secure Chandrakar’s return from Oman, highlighting the strong bilateral relationship between the two countries.

Authorities also referred to the Free Trade Agreement between India and Oman, which came into effect on June 1, as a sign of strengthening cooperation. Bilateral trade between the two nations stood at USD 11.2 billion during 2025-26.

Before leaving India for Dubai in 2019, Chandrakar reportedly operated a juice shop named “Juice Factory” with his brother in Bhilai, Chhattisgarh.

Chandrakar and Ravi Uppal have previously denied any involvement in the alleged betting racket through a statement issued a few years ago.

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Uttarakhand becomes India’s sixth fully literate state under ULLAS programme

Uttarakhand has been declared India’s sixth fully literate state after crossing the prescribed adult literacy benchmark under NEP 2020 and the ULLAS programme.

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Pushkar Singh Dhami

Uttarakhand has been declared the sixth fully literate state in India after achieving the prescribed adult literacy benchmarks under the National Education Policy (NEP) 2020 and the ULLAS (Understanding Lifelong Learning for All in Society) programme.

The recognition marks a significant milestone in the state’s education sector. Officials said the literacy benchmark was achieved in line with the standards laid down by the Department of School Education and Literacy under the Union Ministry of Education.

Following the achievement, Governor Lieutenant General (Retd.) Gurmeet Singh approved the proposal declaring Uttarakhand a fully literate state.

Joins five states with fully literate status

With this declaration, Uttarakhand joins Mizoram, Goa, Tripura, Himachal Pradesh and Sikkim, which had already attained fully literate status.

Officials said Uttarakhand’s literacy rate has now crossed 98 per cent, enabling the state to meet the required criteria for the recognition.

Chief Minister calls it a major milestone

Chief Minister Pushkar Singh Dhami described the achievement as an important milestone for Uttarakhand. He credited the success to the combined efforts of citizens and the government’s sustained focus on improving literacy.

Congratulating the people of the state, he said such collective efforts would contribute to the vision of a developed India by 2047. He also said the government would continue working to expand digital literacy, financial literacy, continuing education and life skills among citizens.

The proposal to declare Uttarakhand a fully literate state had earlier received approval from the state cabinet on June 19.

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Delhi-NCR Braces for Heavy Rain as IMD Issues Orange Alert, Waterlogging Reported

Heavy monsoon showers lashed Delhi-NCR, prompting the IMD to issue an Orange Alert. Waterlogging was reported in several areas as more rainfall is forecast.

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Delhi Rain July 2026

Delhi and the National Capital Region (NCR) witnessed another spell of monsoon rain early on Thursday, bringing relief from the recent humid weather while causing waterlogging in several parts of the city.

The India Meteorological Department (IMD) has issued an Orange Alert for Delhi, warning of heavy rainfall through most of the day. The weather department has also predicted continued monsoon activity across several northern states over the coming days.

Waterlogging reported in several parts of Delhi

Continuous rainfall led to waterlogging at multiple locations across the capital, affecting traffic movement in some areas.

Among the locations where water accumulation was reported were the New Delhi Railway Station, Munirka, and several other parts of the city as rain continued through the morning.

Despite the disruptions, the showers brought welcome relief to residents after days of hot and humid conditions.

Amit Shah reviews rain situation with affected states

Amid heavy rainfall in different parts of the country, Union Home Minister Amit Shah spoke with the chief ministers of Kerala, Maharashtra, Gujarat, and Jammu and Kashmir to review the situation.

According to officials, the Home Minister assured the states of all possible assistance from the Centre following recent weather-related incidents, including a debris collapse in Kerala’s Wayanad, flash floods in Jammu’s Doda district, and deadly rain-related incidents and disruptions reported in Maharashtra and Gujarat.

IMD forecasts continued rainfall across North India

The IMD has forecast fairly widespread to widespread rainfall over Haryana, Chandigarh, Delhi, and West Uttar Pradesh until July 10.

The weather agency also expects a fresh spell of rainfall to continue over Northeast Uttar Pradesh until July 13, while East Rajasthan is likely to experience similar monsoon activity on July 9.

A widespread monsoon spell had already covered large parts of North India on Wednesday, providing relief from the prevailing heat and improving weather conditions across the region.

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