Lifestyle

Blood Cancer drug, Ibrutinib, contributes to Hypertension – A study reveals

Researchers at the Ohio State Wexner Medical Center in a new study found that the blood cancer drug ibrutinib contributed to new or worsened hypertension within 6 months of treatment.

Published

7 years ago

October 4, 2019

[vc_row][vc_column][vc_column_text]Researchers at the Ohio State Wexner Medical Center in a new study found that the blood cancer drug, ibrutinib contributed to new or worsened hypertension within 6 months of treatment.

The research team also suggests results of the study are the first to tie ibrutinib-related hypertension to other cardiovascular issues, including atrial fibrillation.

“This study provides a clearer picture of the extent of hypertension development among patients taking ibrutinib, while allowing us to tease out what ibrutinib-related hypertension means in the long run for other cardiovascular events and survival,” said lead investigator Daniel Addison, MD, of the Ohio State Wexner Medical Center.

In an effort to know the long-term incidence, severity, and impacts of hypertension development during ibrutinib use, a study was conducted with 562 consecutive patients treated with ibrutinib for B-cell malignancies between 2009 and 2016.

The Study also evaluated the relationship of hypertension on ibrutinib to the development of other Major-Adverse-Cardiovascular-Events (MACE), including arrhythmias, myocardial infarction, stroke, heart failure, and cardiovascular death.

Further, the preventative and modulatory effects of antihypertensives, by medication-class, on ibrutinib-related hypertension were also assessed by the investigators.

Investigators observed 78.3%(440) patients developed new or worsening hypertension during the follow-up period, which had a median of 30 months.

Also Read: More than 2 eggs per day not good for your heart: Study

The study showed that new hypertension developed in 71.6% of ibrutinib-users with a time-to-50% cumulative incidence of 4.2 months while among those without preceding hypertension, 17.7% developed high-grade hypertension.

Moreover, in multivariable regression containing known predictors of MACE, new or worsened hypertension was associated with increased MACE. No single-antihypertensive class was associated with prevention or control of ibrutinib-related hypertension. However, antihypertensive initiation was associated with a lower risk of MACE , the researching team stated.

Collectively, these data suggested ibrutinib is largely associated with substantial increase in the incidence and severity of hypertension and that hypertension development may suggest a higher risk of subsequent cardiotoxic events.

In a release from American Society of Hematology, Addison noted due to the frequency of ibrutinib’s use as a treatment it is important to keep the increased risk profile in mind to protect against additional heart related issues.

“(Ibrutinib) has become ubiquitous to the treatment of many blood cancers and will continue to be applied to other cancers,” Addison said. “Accordingly, we need to find the best ways to manage high blood pressure and protect against other heart-related issues.”

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India News

Bank holiday on September 14: Banks closed in these cities

Banks will remain closed on September 14 in nine cities, including Mumbai, Bengaluru, Chennai and Hyderabad, due to Ganesh Chaturthi and related festival observances.

Published

2 months ago

September 12, 2026

APNLive Desk

The bank holiday on September 14 will affect branches in select cities across India as banks observe a regional holiday for Ganesh Chaturthi and related festival observances.

September 14, 2026, falls on a Monday and is listed as a holiday for Ganesh Chaturthi, Ganesh Puja, Varasiddhi Vinayaka Vrata, Vinayakar Chathurthi and Hartalika in certain banking centres.

Bank holiday on September 14: Full city-wise list

According to the holiday listings, bank branches will remain closed on September 14 in the following centres:

City	Festival/occasion
Belapur	Ganesh Chaturthi/Ganesh Puja/related observances
Bengaluru	Ganesh Chaturthi/Ganesh Puja/related observances
Bhubaneswar	Ganesh Chaturthi/Ganesh Puja/related observances
Chennai	Ganesh Chaturthi/Ganesh Puja/related observances
Hyderabad	Ganesh Chaturthi/Ganesh Puja/related observances
Mumbai	Ganesh Chaturthi/Ganesh Puja/related observances
Nagpur	Ganesh Chaturthi/Ganesh Puja/related observances
Panaji	Ganesh Chaturthi/Ganesh Puja/related observances
Vijayawada	Ganesh Chaturthi/Ganesh Puja/related observances

The holiday is therefore not applicable to bank branches across the entire country. Bank holidays in India vary by state and banking centre, depending on local festivals and occasions.

Why are banks closed on September 14?

September 14 marks Ganesh Chaturthi in 2026. The festival falls on Monday this year, with the date confirmed as September 14.

The banking holiday calendar uses different names for the observance across centres, including Ganesh Chaturthi, Ganesh Puja, Varasiddhi Vinayaka Vrata, Vinayakar Chathurthi and Hartalika.

The National Stock Exchange’s 2026 holiday circular also lists September 14 as a trading holiday for Ganesh Chaturthi.

Will online banking services work on September 14?

The closure applies to physical bank branches in the affected centres. Customers can generally continue to use digital banking channels such as mobile banking, internet banking and UPI, although specific services can depend on the bank.

Customers who need to visit a branch for cash deposits, withdrawals, account-related work or other in-person services should check the holiday status of their particular branch before visiting.

What about banks in other cities?

Banks in cities that are not covered by the September 14 regional holiday are not automatically closed because of Ganesh Chaturthi.

The bank holiday calendar is centre-specific, so customers should check their bank’s branch holiday schedule before planning a branch visit.

Lifestyle

Who is Kaziah Liz Mejo, the 19-year-old who won Miss Universe India 2026?

Kerala’s 19-year-old law student and model Kaziah Liz Mejo has won Miss Universe India 2026. She will represent India at the Miss Universe pageant in Puerto Rico.

Published

2 months ago

August 25, 2026

APNLive Desk

Kaziah Liz Mejo has been crowned Miss Universe India 2026, becoming the first Keralite to win the national title. The 19-year-old law student and model from Mavelikkara, Kerala, won the crown at the pageant finale in Jaipur on Sunday.

With the victory, Kaziah Liz Mejo will now represent India at the 75th Miss Universe pageant, which is scheduled to take place in Puerto Rico in November. She emerged as the winner after competing against 52 other finalists.

Who is Kaziah Liz Mejo?

Kaziah Liz Mejo is a law student and model from Mavelikkara, Kerala. Although her latest victory has brought her national attention, she already had experience in beauty pageants before winning the Miss Universe India 2026 crown.

She won the Miss Teen Diva 2024 title at the age of 17. In 2025, she represented India at Miss Teen International and finished as the first runner-up. Earlier in 2026, she also won the Miss Universe Kerala title and became the youngest state titleholder.

Her latest achievement has added another milestone to her pageant journey, as she is the first Keralite to win the Miss Universe India title.

Kaziah Liz Mejo grew up in Abu Dhabi

Born in 2007, Kaziah spent her childhood in Abu Dhabi, UAE. She studied at Emirates National School, St Joseph’s School and Abu Dhabi Indian School.

She is currently pursuing law alongside her modelling career. Her interests also extend beyond academics and pageantry.

According to information cited from the Miss Teen Diva website, Kaziah has trained in classical dance for 12 years. She also sings and plays the drums and violin. She has explored public speaking and acting as well.

Kaziah also made her acting debut with the Malayalam film Shylock.

Kaziah Liz Mejo’s pageant journey

Kaziah’s Miss Universe India 2026 victory follows several achievements in the pageant circuit. After winning Miss Teen Diva 2024, she went on to represent India at Miss Teen International 2025, where she finished as the first runner-up.

Her 2026 journey continued with the Miss Universe Kerala title before she competed at the national pageant in Jaipur.

The finale jury included former Miss Universe Sushmita Sen, who led the panel. Former Miss Universe India winners Urvashi Rautela and Celina Jaitley were also part of the judging panel.

Who were the runners-up?

Vaishnavi Gannesh from Tamil Nadu was named the first runner-up and also won the Miss International India 2026 title, while Gujarat’s Anushri Satavlekar finished as the second runner-up.

Kaziah was crowned by last year’s Miss Universe India winner Manika Vishwakarma, who had represented India at the international pageant.

What is next for Kaziah Liz Mejo?

Kaziah Liz Mejo’s next major assignment will be the 75th Miss Universe pageant in Puerto Rico. She is scheduled to travel there in November to represent India at the international competition.

Lifestyle

15 August 2026 wishes to share patriotic messages with friends and family

Looking for Independence Day wishes? Here are 10 patriotic messages to share with friends, family and loved ones on August 15.

Published

3 months ago

August 14, 2026

APNLive Desk

15 August Independence Day patriotic wishes and messages

India celebrates Independence Day every year on August 15. The occasion is marked by remembering the struggles and sacrifices of those who fought for the country’s freedom.

On this special day, people often exchange wishes through social media, WhatsApp and text messages. If you are looking for patriotic messages to send to friends and family, here are 10 options for Independence Day 2026.

10 patriotic Independence Day wishes for August 15

1. A patriotic message

The tricolour is our pride and India is our identity. Remembering the heroes of the nation, wishing you and your family a very happy Independence Day. Jai Hind!

2. Remembering the freedom fighters

A heartfelt salute to the brave souls who sacrificed their lives for India’s freedom. Wishing everyone a very happy Independence Day.

3. Independence Day message for friends

On the festival of freedom, may the spirit of patriotism always remain in our hearts and bring smiles to our faces. Wishing all my friends a very happy August 15. Jai Hind, Jai Bharat!

4. Independence Day wish for family

Salute to our motherland, India, which fills us with pride. Wishing my entire family a very happy Independence Day.

5. A message celebrating the tricolour

The tricolour flying high in the sky represents unity, courage and honour. Let us always uphold its dignity. Happy Independence Day!

6. Message for children and youth

Freedom is not just a right but also a great responsibility. Let us contribute towards making our country better. Wishing you a very happy Independence Day.

7. A message dedicated to soldiers

A salute to the brave soldiers guarding the nation’s borders, because of whom we feel safe in our homes. Salute to all the courageous soldiers and best wishes on Independence Day.

8. A heartfelt Independence Day message

The fragrance of our soil, the pride of the tricolour and respect for our motherland are part of our identity. Wishing you and your family a very happy Independence Day.

9. Independence Day message for social media

Say with pride that we are Indians; the tricolour is our identity. May the spirit of patriotism always remain alive in our hearts. Happy Independence Day! Jai Hind!

10. Wish for India’s bright future

On this Independence Day, let us pledge to always uphold the unity, integrity and honour of our country. Wishing everyone a very happy August 15.

Independence Day is also an occasion to reflect on our responsibilities towards the nation. The day can inspire us to learn from the struggles of the freedom fighters and contribute to the country’s progress.