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A non-invasive method developed to assess burn wound healing

Published

8 years ago

on

Burn Injury

[vc_row][vc_column][vc_column_text]By Dinesh C Sharma

Assessing a burn wound to know the status of healing is currently an invasive process such as biopsy which is both painful and scarring. Now scientists have developed a non-invasive technique that involves mere flash of a laser light to assess healing.

The method exploits a particular property of some tissue proteins – ability to re-emit light upon absorption. Such proteins, known as tissue fluorophores, have chemical compounds that can re-emit light. Collagen is one such protein that is vital in wound healing. So when a laser light is flashed on tissues under examination, the amount of re-emitted light from the healing tissue directly corresponds to collagen concentration, which in turn, indicates the status of recovery process.

Researchers at the Manipal Academy of Higher Educationused commercially available 325 nm laser light to inspect healing by exploring tissue fluorophores, and a detector to collect re-emitted light. The re-emitted spectra were recorded using a fibre optic probe kept very close – about three mm – to the wound site. The spectra was then analysed in a spectrograph connected to a computer.

The collagen levels measured by this technique, known as autofluorescence, were validated by biochemical tests of patient tissues. The comparison showed that autofluorescence was consistent and suitable for assessment of burn wound healing. This study also shown tissue collagen can be used as an optical biomarker for assessing burn wound healing, researchers explained. Tissue samples were collected from burn patients admitted to the Department of Plastic Surgery and Burns,Kasturba Medical College.

In earlier studies, the technique was used in lab-induced wounds in animals. Now it has been tested in tissue samples from human burn patients suffering from different degree of burn wounds. Tissue formed following treatment was excised before grafting and utilized for autofluorescence measurement.

“Our technique is user-friendly and solely dependent on excitation and emission of tissue fluorophores without the addition of any external dye molecule. This helps maintain tissue architecture during the assessment of healing,” Dr VijendraPrabhu of Department of Biotechnology at the Manipal Institute of Technology, a member of the research team, told India Science Wire.

For clinical management of wounds, periodic evaluation of injured tissue is necessary to know progress of healing. Sometimes wound assessment is done by trained clinicians but it is a subjective method. The other method is to conduct histopathology and biochemicalanalysis to measure amount of collagen deposited. Repetitive invasive tests can result in fresh wounds and possibility of infection and scarring.

Through autofluorescence technique, collagen information of the tissue can be gathered in just 10 to 15 seconds. “It can provide complementary data conducive to making clinical decisions. After successful testing on clinical samples, we are ready for mass testing on burn wound patients. This system can also be utilized to test collagen disorders in patients,” Dr Prabhu said.

The research team included researchers from Manipal Academy of Higher Education – Prof K.K.Mahato (Department of Biophysics, School of Life Sciences); Dr. Vijendra Prabhu (Manipal Institute of Technology); Anusha Acharya (School of Life Sciences);  Prof B.S. Satish Rao (Department of Radiation Biology and Toxicology),Bharath Rathnakar (Department of Biophysics); Dr. Pramod Kumar (Department of Plastic Surgery and Burns) and Dr. Vasudeva Guddattu (Department of Statistics).The study was funded by the Indian Council of Medical Research (ICMR), and research findings have been published in Journal of Biophotonics. (India Science Wire)[/vc_column_text][/vc_column][/vc_row]

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PM Modi hails ISRO after successful GSLV-F17 launch, calls it proud moment

PM Modi congratulated ISRO after GSLV-F17 successfully launched EOS-05, calling the achievement a proud moment for India.

Published

1 week ago

on

September 4, 2026

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Prime Minister Narendra Modi on Friday congratulated the Indian Space Research Organisation (ISRO) after the successful launch of the GSLV-F17 rocket carrying the EOS-05 Earth observation satellite, describing the achievement as a proud moment for the nation.

The GSLV-F17 lifted off at 2:55 a.m. IST from the Satish Dhawan Space Centre in Sriharikota, Andhra Pradesh. The EOS-05 satellite was subsequently placed into its designated sub-geosynchronous transfer orbit.

PM Modi praises ISRO’s growing capabilities

In a post on X, PM Modi said the successful mission reflected the excellence, innovation and expanding capabilities of India’s space sector.

He also highlighted the growing partnership between ISRO and Indian industry, saying it was strengthening India’s space programme and expanding capabilities across the wider space ecosystem.

The prime minister described the successful launch of GSLV-F17 carrying EOS-05 as another outstanding achievement by ISRO and a matter of national pride.

EOS-05 strengthens earth observation capabilities

According to the report, EOS-05 is India’s first-ever imaging satellite from geosynchronous orbit. The satellite is designed to provide continuous observation of the country from an altitude of nearly 36,000 km above Earth.

The mission is expected to strengthen India’s earth observation capabilities and support advanced imaging and observation applications.

ISRO Chairman Dr V Narayanan expressed satisfaction with the mission, saying the satellite was precisely injected into its intended orbit.

Mission Director Thomas Kurian described the launch as a significant milestone for the GSLV programme. He said it was the 19th flight of the GSLV and noted that EOS-05 is the heaviest satellite the launch vehicle has placed into a geosynchronous transfer orbit or sub-GTO orbit.

GSLV-F17 launch vehicle details

The GSLV-F17 stands 51.7 metres tall and has an approximate liftoff mass of 420.5 tonnes.

Science and Technology Minister Jitendra Singh also congratulated the ISRO team following the successful mission. He described EOS-05 as a state-of-the-art Earth observation satellite capable of advanced imaging across visible, infrared, multispectral and hyperspectral bands.

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Indian-origin astronaut Anil Menon begins first mission to International Space Station

Indian-origin NASA astronaut Anil Menon has launched aboard Soyuz MS-29 on his first mission to the International Space Station, where he is expected to spend around eight months conducting research.

Published

2 months ago

on

July 14, 2026

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Indian-origin NASA astronaut Anil Menon has embarked on his first journey into space after successfully launching aboard Russia’s Soyuz MS-29 spacecraft to the International Space Station (ISS).

The mission lifted off from the historic Baikonur Cosmodrome in Kazakhstan at 8:17 PM on Tuesday. Menon was accompanied by Russian cosmonauts Pyotr Dubrov and Anna Kikina as the three-member crew began their expedition to the orbiting laboratory.

Crew to spend about eight months aboard ISS

The Soyuz MS-29 spacecraft is expected to dock with the International Space Station a little over three hours after launch. Once aboard the ISS, the crew will carry out a range of scientific research and technology demonstration projects during their mission.

The expedition is scheduled to last approximately eight months, with the crew expected to return to Earth in 2027 after completing their planned activities in orbit.

Menon’s maiden spaceflight marks a significant milestone in his astronaut career as he joins the International Space Station crew for long-duration research and operational work.

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Astronaut Shubhanshu Shukla to meet PM Modi after return from historic space mission

Astronaut Shubhanshu Shukla, who recently returned from the ISS as part of the Axiom-4 mission, will meet PM Modi this evening. Parliament will also hold a special discussion on his historic journey.

Published

1 year ago

on

August 18, 2025

By

Subhanshu shukla

Indian astronaut Group Captain Shubhanshu Shukla, the first Indian to visit the International Space Station (ISS), will meet Prime Minister Narendra Modi this evening at his official residence in New Delhi.

PM Modi to host meeting with astronaut

According to officials, the meeting at 7 Lok Kalyan Marg is expected to take place between 5 pm and 5:30 pm. Shukla, who arrived in India on Sunday, will also be part of the National Space Day celebrations scheduled for August 23.

Warm welcome in India

The astronaut was greeted at the airport by his family, Science and Technology Minister Jitendra Singh, Delhi Chief Minister Rekha Gupta, and hundreds of citizens waving the national flag. Shukla had been in the United States for a year, preparing for the Axiom-4 mission, which launched from Florida on June 25 and docked at the ISS the next day. He served as the mission’s pilot.

Emotional note from Shukla

Before his return, Shukla shared an emotional post on Instagram, expressing mixed feelings of leaving his space colleagues while being eager to meet his loved ones and people of India. He also quoted a song from the film Swades, which he had chosen as his anthem on the launch day.

Parliament session on India’s space journey

In honour of Shukla’s mission, the Lok Sabha is holding a special session today to discuss “India’s first astronaut aboard the ISS – critical role of space programme for Viksit Bharat by 2047.” Union minister Kiren Rijiju said the discussion would highlight the importance of India’s space achievements and future goals.

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