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Scientists identify protein that helps dengue and JE viruses to multiply

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[vc_row][vc_column][vc_column_text]By Yogesh Sharma

When dengue virus infects human bodies, white blood cells get activated to fight it. But instead of destroying the virus, white blood cells are targeted and infected by the virus. The virus fools the immune system to get around its defenses and infect more cells. As white blood cells travel through the lymphatic system, the virus spreads throughout the body.

Now a collaborative study led by a team of Indian scientists has identified a key protein which helps dengue as well as Japanese Encephalitis viruses replication inside human body by inhibiting anti-viral cytokines. This finding could pave way for development of targeted therapeutic agents against dengue and JE viruses.

Normally when platelets circulate through blood vessels with an intact endothelium layer, they remain in their original inactivated state. During dengue infection, platelets get activated, and they release an elevated amount of cell-signalling protein called Platelet Factor 4 (PF4).

In the study which used blood samples from dengue patients, scientists found that Platelet Factor 4 inhibits anti-viral machineries of immune cells by inhibiting secretion of anti-viral cytokines (small proteins) such as interferon. In order to inhibit function of Platelet Factor 4 scientists targeted its receptor called CXCR3. Using a small molecule antagonist to CXCR3, researchers could inhibit the virus replication in vitro as well as in vivo.

“We have shown that inhibition of PF4-CXCR3 axis can abrogate virus replication. We feel that the same mechanism may exist in other viruses too. Therefore, our findings indicate development of potential targeted anti-viral drug,” explained Dr. Prasenjit Guchhait of Faridabad-based Regional Centre for Biotechnology, who designed the study, while speaking to India Science Wire.

Since this approach may help find new anti-viral drugs for not just dengue and JEV but other viruses too, the research team is now validating its findings in animal studies involving genetically modified mouse with inactivated PF4 gene. Researchers hope that these mice may exhibit less infection against these viruses. Besides, they are also working on designing better small molecules against PF4 or CXCR3.

The research team included Amrita Ojha, Angika Bhasym, Gowtham Annarapu, Teena Bhakuni, Sudhanshu Vrati, Prasenjit Guchhait (Regional Centre for Biotechnology, Faridabad); Sriparna Mukherjee, Irshad Akbar and Anirban Basu (National Brain Research Centre, Manesar); Tulika Seth, Naval K. Vikram (AIIMS, Delhi); Sankar Bhattacharyya (Translational Health Science and Technology Institute). The recent research results have been published in the journal EBioMedicine.  (India Science Wire)[/vc_column_text][/vc_column][/vc_row]

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PM Modi hails ISRO after successful GSLV-F17 launch, calls it proud moment

PM Modi congratulated ISRO after GSLV-F17 successfully launched EOS-05, calling the achievement a proud moment for India.

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Prime Minister Narendra Modi on Friday congratulated the Indian Space Research Organisation (ISRO) after the successful launch of the GSLV-F17 rocket carrying the EOS-05 Earth observation satellite, describing the achievement as a proud moment for the nation.

The GSLV-F17 lifted off at 2:55 a.m. IST from the Satish Dhawan Space Centre in Sriharikota, Andhra Pradesh. The EOS-05 satellite was subsequently placed into its designated sub-geosynchronous transfer orbit.

PM Modi praises ISRO’s growing capabilities

In a post on X, PM Modi said the successful mission reflected the excellence, innovation and expanding capabilities of India’s space sector.

He also highlighted the growing partnership between ISRO and Indian industry, saying it was strengthening India’s space programme and expanding capabilities across the wider space ecosystem.

The prime minister described the successful launch of GSLV-F17 carrying EOS-05 as another outstanding achievement by ISRO and a matter of national pride.

EOS-05 strengthens earth observation capabilities

According to the report, EOS-05 is India’s first-ever imaging satellite from geosynchronous orbit. The satellite is designed to provide continuous observation of the country from an altitude of nearly 36,000 km above Earth.

The mission is expected to strengthen India’s earth observation capabilities and support advanced imaging and observation applications.

ISRO Chairman Dr V Narayanan expressed satisfaction with the mission, saying the satellite was precisely injected into its intended orbit.

Mission Director Thomas Kurian described the launch as a significant milestone for the GSLV programme. He said it was the 19th flight of the GSLV and noted that EOS-05 is the heaviest satellite the launch vehicle has placed into a geosynchronous transfer orbit or sub-GTO orbit.

GSLV-F17 launch vehicle details

The GSLV-F17 stands 51.7 metres tall and has an approximate liftoff mass of 420.5 tonnes.

Science and Technology Minister Jitendra Singh also congratulated the ISRO team following the successful mission. He described EOS-05 as a state-of-the-art Earth observation satellite capable of advanced imaging across visible, infrared, multispectral and hyperspectral bands.

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Indian-origin astronaut Anil Menon begins first mission to International Space Station

Indian-origin NASA astronaut Anil Menon has launched aboard Soyuz MS-29 on his first mission to the International Space Station, where he is expected to spend around eight months conducting research.

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Indian-origin NASA astronaut Anil Menon has embarked on his first journey into space after successfully launching aboard Russia’s Soyuz MS-29 spacecraft to the International Space Station (ISS).

The mission lifted off from the historic Baikonur Cosmodrome in Kazakhstan at 8:17 PM on Tuesday. Menon was accompanied by Russian cosmonauts Pyotr Dubrov and Anna Kikina as the three-member crew began their expedition to the orbiting laboratory.

Crew to spend about eight months aboard ISS

The Soyuz MS-29 spacecraft is expected to dock with the International Space Station a little over three hours after launch. Once aboard the ISS, the crew will carry out a range of scientific research and technology demonstration projects during their mission.

The expedition is scheduled to last approximately eight months, with the crew expected to return to Earth in 2027 after completing their planned activities in orbit.

Menon’s maiden spaceflight marks a significant milestone in his astronaut career as he joins the International Space Station crew for long-duration research and operational work.

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Astronaut Shubhanshu Shukla to meet PM Modi after return from historic space mission

Astronaut Shubhanshu Shukla, who recently returned from the ISS as part of the Axiom-4 mission, will meet PM Modi this evening. Parliament will also hold a special discussion on his historic journey.

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Subhanshu shukla

Indian astronaut Group Captain Shubhanshu Shukla, the first Indian to visit the International Space Station (ISS), will meet Prime Minister Narendra Modi this evening at his official residence in New Delhi.

PM Modi to host meeting with astronaut

According to officials, the meeting at 7 Lok Kalyan Marg is expected to take place between 5 pm and 5:30 pm. Shukla, who arrived in India on Sunday, will also be part of the National Space Day celebrations scheduled for August 23.

Warm welcome in India

The astronaut was greeted at the airport by his family, Science and Technology Minister Jitendra Singh, Delhi Chief Minister Rekha Gupta, and hundreds of citizens waving the national flag. Shukla had been in the United States for a year, preparing for the Axiom-4 mission, which launched from Florida on June 25 and docked at the ISS the next day. He served as the mission’s pilot.

Emotional note from Shukla

Before his return, Shukla shared an emotional post on Instagram, expressing mixed feelings of leaving his space colleagues while being eager to meet his loved ones and people of India. He also quoted a song from the film Swades, which he had chosen as his anthem on the launch day.

Parliament session on India’s space journey

In honour of Shukla’s mission, the Lok Sabha is holding a special session today to discuss “India’s first astronaut aboard the ISS – critical role of space programme for Viksit Bharat by 2047.” Union minister Kiren Rijiju said the discussion would highlight the importance of India’s space achievements and future goals.

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