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Cancer can recur from blood transfusion, warn researchers

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Cancer can recur from blood transfusion, warn researchers

[vc_row][vc_column][vc_column_text]In a study, researchers have claimed that receiving blood transfusion during liver cancer surgery (hepatocellular carcinoma) increases the risk of cancer recurrence and dying prematurely.

The risk was markedly increased even when only a small amount of blood was transfused, researchers said. The study is being presented at the ‘European Society of Anaesthesiology’ in Vienna, Austria (1-3 June).

Findings showed that transfusion of one to four units of blood increased the risk of cancer recurrence by 23 per cent and death by 55 per cent compared to matched controls.

“Our findings from a large cohort highlighted a significant association between red blood cell transfusions and the risk of cancer recurrence as well as a dose-response relationship between the number of transfusions and death after curative surgery for liver cancer,” said Dr Ying-Hsuan Tai from Taipei Medical University Shuang Ho Hospital in Taiwan who led the research.

“The reason why blood transfusions substantially worsen cancer prognosis remains unclear, but it is likely to be related to the suppressive effects on the immune system,” Dr Tai added.

Hepatocellular carcinoma (HCC) is the fifth most common form of cancer worldwide and the third most common cause of cancer-related deaths. It occurs frequently in people with cirrhosis (scarring of the liver) due to previous damage from hepatitis B or C virus, or long-term alcohol abuse. Surgery to remove cancer and a margin of healthy tissue that surrounds it (resection) is a curative treatment for people with early-stage liver cancers who have a normal liver function.

In this study, Tai and colleagues investigated the effect of perioperative blood transfusion on cancer prognosis following HCC resection in 1,469 patients without lymph node involvement or metastasis undergoing surgery between 2005 and 2016.

Researchers assessed postoperative disease-free survival and overall survival up to September 2018. Using statistical modelling (a technique called the inverse probability of treatment weighting) they were able to match patients who had equivalent age and health conditions when comparing their outcomes.

Almost one in three patients (30 per cent; 447 patients) received one to four units of allogeneic (from another individual) blood during or within seven days of surgery, while more than one in 10 (12 per cent; 179 patients) were given more than four units.

During a median 45 month follow-up, analyses showed that cancer was 23 per cent more likely to recur in patients who received a transfusion (1-4 units) compared to those not given a transfusion.

While those who received more than four units faced an 18 per cent greater risk of recurrence compared with those who received none.

Compared to those not given a transfusion, patients given 1-4 units of blood were 55 per cent more likely to die from any cause, while those receiving four or more units had almost double the risk of death.

(With ANI Inputs)[/vc_column_text][/vc_column][/vc_row]

Latest Science News

Astronaut Shubhanshu Shukla to meet PM Modi after return from historic space mission

Astronaut Shubhanshu Shukla, who recently returned from the ISS as part of the Axiom-4 mission, will meet PM Modi this evening. Parliament will also hold a special discussion on his historic journey.

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Indian astronaut Group Captain Shubhanshu Shukla, the first Indian to visit the International Space Station (ISS), will meet Prime Minister Narendra Modi this evening at his official residence in New Delhi.

PM Modi to host meeting with astronaut

According to officials, the meeting at 7 Lok Kalyan Marg is expected to take place between 5 pm and 5:30 pm. Shukla, who arrived in India on Sunday, will also be part of the National Space Day celebrations scheduled for August 23.

Warm welcome in India

The astronaut was greeted at the airport by his family, Science and Technology Minister Jitendra Singh, Delhi Chief Minister Rekha Gupta, and hundreds of citizens waving the national flag. Shukla had been in the United States for a year, preparing for the Axiom-4 mission, which launched from Florida on June 25 and docked at the ISS the next day. He served as the mission’s pilot.

Emotional note from Shukla

Before his return, Shukla shared an emotional post on Instagram, expressing mixed feelings of leaving his space colleagues while being eager to meet his loved ones and people of India. He also quoted a song from the film Swades, which he had chosen as his anthem on the launch day.

Parliament session on India’s space journey

In honour of Shukla’s mission, the Lok Sabha is holding a special session today to discuss “India’s first astronaut aboard the ISS – critical role of space programme for Viksit Bharat by 2047.” Union minister Kiren Rijiju said the discussion would highlight the importance of India’s space achievements and future goals.

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Shubhanshu Shukla pens emotional note as he returns to India after space mission

Indian astronaut Shubhanshu Shukla penned an emotional Instagram post as he returned to India after his 18-day ISS mission, marking a milestone in India’s space journey.

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Indian astronaut Group Captain Shubhanshu Shukla has shared an emotional Instagram post as he heads back home after completing his 18-day mission aboard the International Space Station (ISS).

Astronaut reflects on mixed emotions

In his heartfelt message, written from the aircraft, Shukla expressed the whirlwind of emotions he felt while leaving behind his fellow astronauts, who had been his family during the mission. “As I sit on the plane to come back to India, I have a mix of emotions running through my heart. I feel sad leaving a fantastic group of people behind who were my friends and family for the past year during this mission. I am also excited about meeting all my friends, family and everyone in the country for the first time post mission. I guess this is what life is — everything all at once,” he wrote.

Acknowledges support and inspiration

The astronaut thanked everyone for the love and support he received throughout his journey. He also recalled the words of his commander Peggy Whitson, saying, “Goodbyes are hard, but we need to keep moving in life. As my commander Peggy Whitson fondly says, ‘The only constant in spaceflight is change’. I believe that applies to life as well.”

Shukla ended his note with a line from the song Yun Hi Chala Chal from the film Swades, reflecting his spirit of resilience.

Link to India’s space ambitions

Shukla’s return comes at a crucial time as India advances its space programme. Prime Minister Narendra Modi had earlier mentioned that the astronaut would soon return and that he was tasked with documenting his training and ISS stay. This record will serve as a valuable reference for Gaganyaan, India’s first human spaceflight mission.

Over the past year, Shukla trained extensively at NASA, Axiom, and SpaceX facilities. His flight to the ISS as part of the Axiom 4 mission marked a milestone in India’s preparations for future human space exploration.

The Gaganyaan project aims to send Indian astronauts into orbit aboard an indigenous rocket. The government has also outlined plans for a Bharatiya Antariksh Station by 2035 and a crewed mission to the moon by 2040.

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Shubhanshu Shukla becomes second Indian in space, lifts off for ISS aboard Axiom-4 mission

Group Captain Shubhanshu Shukla becomes the second Indian astronaut to travel to space after four decades, aboard the Axiom-4 mission to the International Space Station.

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Group Captain Shubhanshu Shukla of the Indian Air Force has etched his name in history as the second Indian astronaut to travel to space. Launching aboard the SpaceX Crew Dragon on the Axiom-4 mission, Shukla began his journey from NASA’s Kennedy Space Center in Florida, from the very launchpad that propelled Neil Armstrong’s Apollo 11 moon mission in 1969.

Four decades after Wing Commander Rakesh Sharma became the first Indian to journey into space in 1984, Shukla’s mission marks a monumental milestone for India’s space ambitions. Speaking ahead of the mission, Shukla expressed the emotional weight of the moment, saying, “I carry with me not just instruments and equipment, but the hopes and dreams of a billion hearts.”

A multinational crew on a scientific journey

Group Captain Shukla is joined by Commander Peggy Whitson from the US, Slawosz Uznanski-Wisniewski from Poland, and Tibor Kapu from Hungary. The four-member crew is on a mission to the International Space Station (ISS), where they are scheduled to arrive after a 28-hour journey and dock around 4:30 pm tomorrow.

The fortnight-long mission includes the execution of 60 scientific experiments, with seven of them designed by Indian researchers. Shukla is also expected to engage in an interaction with a VIP from space during the mission, adding a special human touch to this scientific voyage.

A mission delayed, but not denied

The Axiom-4 launch had faced multiple delays due to unfavorable weather and technical complications. June 25 finally saw the successful launch, marking NASA’s sixth official date announcement for the mission.

Before lift-off, Shukla shared a heartfelt message with his family: “Just wait for me, I’m coming.” The Indian pilot had been under quarantine for over a month in preparation, ensuring he was in optimal health for the journey.

As the spacecraft orbits Earth en route to the ISS, India watches with pride and anticipation, inspired once again by the courage of its space pioneers.

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