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Healthy lifestyle can overcome even genetic risk of heart disease: Study

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Healthy lifestyle can overcome even genetic risk of heart disease: Study

By Dinesh C Sharma

Study conducted in Chennai finds individuals who consumed a low-fat diet had higher levels of good cholesterol despite carrying a risky gene variant

New Delhi: It is often said in the context of lifestyle diseases that “genetics loads the gun, lifestyle pulls the trigger.” This means that unhealthy lifestyle can easily trigger diabetes and heart disease among people who are genetically predisposed to them. Now a study has shown that even if one is genetically prone to diabetes or heart disease, one can reduce the risk with healthy lifestyle.

In recent years, several genomic studies have identified genes that are linked with risk of obesity, diabetes and heart disease among different population groups. Such findings make people neglect their lifestyles, as they think that why should they bother if any way they are genetically predisposed to these diseases. The new Indo-British study debunks this, in the case of Indians.

The study has found that people who are genetically more prone to get diabetes and heart disease can reduce their risk with lifestyle modification – consumption of healthy food and physical activity.

Participants in the study conducted in Chennai – considered India’s diabetes capital – who followed a low-fat diet reported higher levels of good cholesterol or HDL despite carrying a gene shown to increase risk of diabetes in earlier studies. Researchers looked at two gene variants – MC4R and TCF7L2 – known to increase risk of metabolic disorders among study participants who were part of an ongoing study called Chennai Urban Rural Epidemiology Study (CURES).

“We examined if the association between MC4R and TCF7L2 genes, and cardio-metabolic traits is modified by dietary factors and physical activity,” explained Dr Vimal S Karani, a member of the research team. “We found that individuals who consumed a low-fat diet had higher levels of good cholesterol despite carrying the risky gene variant. In particular, those who consumed a diet low in polyunsaturated fatty acids (PUFA) had higher levels of good cholesterol despite carrying the same TCF7L2 gene variant.”

Besides analyzing genomic data, researchers evaluated dietary habits through a ‘food frequency questionnaire’ consisting of 222 different foods. It included information about portion size and frequency as well. In the same way, physical activity was measured. Individuals were categorized as ‘vigorously active’ when they both exercised and engaged in demanding work activities, while those in ‘moderately active’ group either exercised or carried out heavy physical work. The rest were separated into sedentary group. The study results have been published in journal PLOS One.

The research team included Vimal S Karani, Szilvia Gaal, Israa Shatwan, Shelini Surendran, Julie A. Lovegrove (University of Reading, UK); Viswanathan Mohan, Dhanasekaran Bodhini, Kandaswamy Ramya, Vasudevan Sudha, Mohan R. Anjana  Venkatesan Radha (Madras Diabetes Research Foundation); and Basma Ellahi (University of Chester, UK).

(This story has not been edited by the APNLive staff. It has been provided through an auto-generated syndicated feed by the India Science Wire)

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Jio extends its Rs 299 or above plan with free JioHotstar and JioFiber

In addition to this, the plan includes a generous 50-day free trial of JioFiber or AirFiber, granting customers high-speed internet access right in their homes.

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On Tuesday, Reliance Jio made a significant announcement by extending its popular unlimited plan priced at ₹299 and above until April 15. This extension is designed to cater to both new customers and existing subscribers, providing a wealth of entertainment options during the highly anticipated Indian Premier League (IPL) season.

The unlimited plan, which was initially introduced on March 17, comes packed with a variety of benefits. Subscribers will enjoy a complimentary 90-day subscription to JioHotstar, which allows streaming on a single device. In addition to this, the plan includes a generous 50-day free trial of JioFiber or AirFiber, granting customers high-speed internet access right in their homes.

One of the standout features of Jio’s unlimited pack is the extensive content it offers. Subscribers will have access to over 800 TV channels, ensuring that they can watch their favorite shows, movies, and live events. Furthermore, the plan grants access to more than 11 over-the-top (OTT) streaming applications, providing an array of entertainment choices that cater to various viewer preferences. Customers can also benefit from unlimited Wi-Fi data, making it easier than ever to stay connected and stream content without worrying about data limits.

This strategic extension of the unlimited plan is a calculated effort by Reliance Jio to capture a larger share of the market as cricket fans around the nation tune in for IPL matches. By offering enticing incentives, Jio aims to attract new subscribers while retaining their existing customer base.

To take advantage of these benefits, current Jio users can choose to recharge with the ₹299 plan or a higher-tier plan that starts at a value of ₹299 and includes 1.5GB of data per day or more. Prospective subscribers can also enroll in the same plan and enjoy the associated perks. Those who recharged prior to March 17 can still benefit from the JioHotstar offering by adding a ₹100 pack to their account.

By enhancing their service offerings, Reliance Jio continues to solidify its position in the competitive telecom industry, delivering exceptional value to its customers during an exciting time for sports and entertainment enthusiasts.

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Vivo T4 5G likely to launch in April: Expected price, features and specifications revealed

Vivo is reportedly planning to launch the T4 5G in India by April 2025. Expected to offer a Snapdragon 7s Gen 3 processor, 7,300mAh battery, and up to 12GB RAM, it aims to build on the success of the T3 5G.

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Vivo T4 5G expected to launch in India with new features

Vivo is gearing up to launch its next mid-range smartphone, the Vivo T4 5G, in India. According to recent reports citing a known tipster, the device could make its debut as early as April 2025, succeeding the Vivo T3 5G which was introduced in March last year. While the brand is yet to make an official announcement, early details have surfaced highlighting the expected pricing, specifications, and key upgrades.

Vivo T4 5G expected price and variants

The upcoming Vivo T4 5G is expected to fall in the Rs 20,000 to Rs 25,000 price bracket. The smartphone is likely to be available in three configurations:

  • 8GB RAM + 128GB storage
  • 8GB RAM + 256GB storage
  • 12GB RAM + 256GB storage

For reference, the Vivo T3 5G was launched at Rs 19,999 for the base 8GB + 128GB model and Rs 21,999 for the 8GB + 256GB variant. The addition of a higher 12GB RAM option suggests Vivo may be targeting power users this time around.

Key specifications and upgrades expected in Vivo T4 5G

The Vivo T4 5G is rumored to feature a 6.67-inch full-HD+ AMOLED quad-curved display with a 120Hz refresh rate, promising a premium viewing experience. It may run on Android 15-based Funtouch OS 15 and could be powered by the Snapdragon 7s Gen 3 chipset.

In terms of photography, the device is tipped to sport a 50MP Sony IMX882 primary camera with OIS, along with a 2MP secondary sensor. The front camera is expected to be a 32MP shooter, aimed at enhancing selfie performance.

One of the notable upgrades could be the inclusion of a 7,300mAh battery with 90W wired fast charging support, which would be a significant step up in battery capacity and charging speed for the segment. Additional features may include an in-display fingerprint sensor, IR blaster, and a sleek 8.1mm profile with a weight of 195g.

With the launch likely around the corner, more details are expected to be revealed by Vivo in the coming weeks.

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iQOO Z10 with 7300mAh battery to launch in India on April 11

iQOO has confirmed the launch of Z10 in India on April 11, featuring a 7300mAh battery, which it claims is the biggest ever in the country.

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iQOO Z10 official teaser showing back panel with round camera housing

Vivo’s sub-brand iQOO has officially confirmed the launch date of its next smartphone for the Indian market, the iQOO Z10, which is set to make its debut on April 11, 2025. The highlight of this upcoming device is its massive 7300mAh battery, which the company claims is the largest ever in an Indian smartphone.

The brand took to social media to announce the Z10, highlighting it as a phone designed for “mega taskers,” aiming to deliver longer battery life for users with heavy usage patterns. This large battery makes it a significant upgrade over the iQOO Z9, which came with a 5,000mAh battery and 44W fast charging.

First look reveals a bold design change

Alongside the launch date announcement, iQOO also revealed the first official teaser image of the Z10. The teaser shows off a marble-like back panel in white and a round camera housing, a notable departure from previous iQOO designs, with some resemblance to Realme’s design aesthetics. More color variants are expected to be unveiled at the launch.

While detailed specifications remain under wraps for now, the Z10 is expected to follow in the footsteps of the Z9, which impressed users with its MediaTek Dimensity 7200 chipset, 50MP Sony IMX882 camera with OIS, and 120Hz AMOLED display.

A quick look back at iQOO Z9

The iQOO Z9 was launched at under ₹20,000 with notable features like:

  • 6.67-inch 120Hz AMOLED display
  • Dimensity 7200 SoC
  • 8GB RAM with up to 256GB storage
  • 50MP Sony IMX882 main camera with OIS
  • 5,000mAh battery with 44W fast charging
  • Funtouch OS 14 based on Android 14

Following its launch, the Z9 series expanded with variants like the iQOO Z9x, Z9 Lite, Z9s, and Z9s Pro.

With the Z10, iQOO aims to set a new benchmark in battery performance, catering to a growing segment of users looking for ultra-long battery life without compromising on performance.

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