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Indian scientists testing dendritic therapy against cervix cancer

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6 years ago

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Indian scientists testing dendritic therapy against cervix cancer

By Dr. TV Venkateswaran and Jyoti Singh

Researchers at the National Institute of Immunology (NII) have identified a tumour antigen that promises to be a potent weapon in combating cervical cancer

New Delhi: Cancer of the uterine cervix, also known as cervical cancer, is the second leading cause of cancer deaths among women in India. Almost one lakh women fall victim to the insidious disease every year in the country.

Researchers at the New Delhi-based National Institute of Immunology (NII) are in the process of fine tuning a solution that promises to add a highly potent weapon to the armoury against this type of cancer. They have extracted and identified a tumour antigen which seems to hold a lot of promise. The antigen has been named SPAG9.

“The tumor antigen, which is expressed in reproductive tract cancers and a variety of malignancies, has proved successful in phase I trials. This means it has been proved to be safe on human subjects. Phase II clinical trials are presently underway to gauge its efficacy. We hope to get positive results by next year,” said Dr Anil Kumar Suri, NII director, in an interview.

The therapeutic vaccine based on the antigen is being tested among 54 patients at Cancer Institute (WIA) at Adyar in Chennai. The trials are being conducted by a team of oncologist led by Dr T. Rajkumar. If proven efficacious, it could change the face of cervix cancer treatment. The human trials are being conducted subsequent to elaborate trials with animal models.

Invasion of foreign bodies like bacteria or virus usually trigger a volley of fighter cells called T cells. These T cells surround germs and fight them. Each type of virus or bacteria requires specific antigen T cells. Vaccination primes the body to potential threats and keeps the arsenal of antigens ever ready to fight an invasion.

However, this cannot happen with cancer. Even though they are rogue elements, cancer cells are after all from within the affected persons themselves. Body’s immune system cannot normally recognize them as a ‘threat’. They, therefore, allow them to proliferate and spread all around the body.

Immunotherapy is a new approach that exploits body’s inner capability to put up a fight against cancer. Under the approach, either immune system is given a boost or the T cells are “trained’’ to identify recalcitrant cancer cells and kill them.

The NII scientists are using this strategy to develop the new weapon against cancer of the cervix.  “We take cells called monocytes from the patient’s blood and modify them into what are called dendritic cells. These cells have efficient antigens to stimulate the ‘fighter’ cells, or T-cells, in the body. They are then primed with the tumour antigen SPAG9, for ten days, and given back to the patients in the form of a vaccine. The ‘educated’ T cells are able to discriminate the cancer cells and put up a fight against them,” explained Dr Suri.

Poor health, malnutrition, unhygienic environment are the main cause of Human papillomavirus (HPV) infection that leads to cervical cancer. Normally our body has tumor suppressor genes and proteins which are able to suppress formation of tumours. The cells in a tumour multiply uncontrollably with hardly any cell death.

NII has outsourced the manufacture of recombinant SPAG9 to Syngene International (Biocon Limited), Bangalore. “If the trials succeed, it will be the first molecule identified in India and will be an example of translational research outcome. Our findings have opened new avenues for novel treatment modalities in battling the deadly disease of cancer worldwide,” said Dr Suri.

Dr. Suri graduated from Hans Raj College, Delhi University and after that did his post-graduation and doctorate from National Dairy Research Institute at Karnal. Subsequently, he did his post- doctorate from Laboratoire pour le contrôle des Reproducteurs, Maisons-Alfort, France. He returned to India in 1985 and joined NII as a scientist.

The thrust of his research is on early detection and diagnosis of cancer and development of targeted approaches for therapeutic interventions for cancer medicine.

Dr Suri has authored 63 high impact publications in reputed international journal and has 15 patents on novel immunotherapeutic method for cancer treatment and diagnosis in India and abroad. He has won the S.S. Guraya Memorial Award, Dr T C Anand Kumar Memorial Oration Award and Rabindra Nath Chakravarti Citation Award.

(This article is from a syndicated feed provided by the India Science Wire)

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OnePlus to launch Nord CE 3 in India, specs and price leaked ahead of global debut

OnePlus may soon expand its affordable smartphone series Nord CE. It is being claimed that the company is going to launch the new OnePlus Nord CE 3 in July this year. As per the leaks, the OnePlus Nord CE 3 will be introduced as a successor to the OnePlus Nord CE 2.

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4 weeks ago

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March 3, 2023

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OnePlus smartphone

OnePlus may soon expand its affordable smartphone series Nord CE. It is being claimed that the company is going to launch the new OnePlus Nord CE 3 in July this year. As per the leaks, the OnePlus Nord CE 3 will be introduced as a successor to the OnePlus Nord CE 2. The information about the phone has also been revealed ahead of its official debut on many digital platforms. However, the company has not yet given any information regarding the same as yet.

According to a report by My Smart Price, the OnePlus Nord CE 3 is expected to launch in July alongside of OnePlus Nord 3. The tipster also has claimed about the specification of the phone as well. Scroll down to know more about the smartphone.

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According to tipster Steve Hemmerstoffer (@OnLeaks), the OnePlus CE 3 will come with a display with 120Hz refresh rate, under which the user will be able to have a high definition display quality while playing videos. The handset is also likely to feature a 6.72 inch Full HD Plus AMOLED display. Earlier it was being said that this phone will be introduced with an IPS LCD screen. However, the confirmation is still awaited.

Leaks also suggested that the OnePlus Nord CE 3 is expected to be powered by the octa-core Snapdragon 782G processor coupled with up to 12GB of RAM and up to 256GB of inbuilt storage. The upcoming OnePlus Nord CE 3 could be equipped with three rear cameras. The phone can get a 50-megapixel Sony IMX890 primary sensor, an 8-megapixel ultra-wide-angle lens, and a 2-megapixel macro lens. The phone is expected to get a 16-megapixel sensor for selfie and video calls.

The handset is said to have an in-display fingerprint sensor, a 5000mAh battery with 80W fast charging support, dual-band Wi-Fi, 5G, 4G LTE, Bluetooth and a USB Type-C port.

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Vivo launches color-changing back panel smartphone V27 Pro in India, check price and specs

The Chinese smartphone manufacturer Vivo has launched its awaited color-changing back panel smartphone V27 Pro in India, along with the lower variant V27. Interested customers can purchase the handset in magic blue and noble black color

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1 month ago

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March 1, 2023

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Vivo V27 Smartphone

The Chinese smartphone manufacturer Vivo has launched its awaited color-changing back panel smartphone V27 Pro in India, along with the lower variant V27. Interested customers can purchase the handset in magic blue and noble black color. Pre-booking of Vivo V27 Pro has started and sales will be from March 6. The sale of Vivo V27 will start from 23 March.

As per the official details, the handset is the upgraded version of the Vivo V25 series, which was launched last year. The company has introduced the Vivo V27 Series with Android 13-based Funtouch OS 13 and MediaTek processor, under which customers will be able to access heavy applications without and lag.

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Know everything about the Vivo’s Vivo V27 and V27 Pro

As per the photos shared by the company, Vivo V27 Pro and Vivo V27 come with a 3D curved screen with a refresh rate of 120Hz that offers users to have a high-definition screen experience while playing any video. It comes with a glass panel that changes color whenever some light or sun rays strike it. Both Vivo V27 Pro and Vivo V27 phones have three rear cameras, and features. The Vivo V27 Pro has a MediaTek Dimensity 8200 processor, while Vivo V27 has Dimensity 7200 5G processor. Both the chipset have been considered the advance chipset in the Indian market.

Price of Vivo’s V27 and V27 Pro

The price of 128 GB storage with 8 GB RAM of Vivo V27 Pro is Rs 37,999. At the same time, the price of 256 GB storage with 8 GB RAM has been kept at Rs 39,999. The 256 GB storage variant with the phone’s 12 GB RAM is priced at Rs 42,999. The price of 128 GB storage with 8 GB RAM of Vivo V27 has been priced at Rs 32,999 and 256 GB storage with 12 GB RAM has been priced at Rs 36,999.

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Samsung set to launch Galaxy S23 FE, design and specs leaked ahead of official launch

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1 month ago

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February 22, 2023

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The leading smartphone manufacturer Samsung recently launched the Galaxy S23 series in India, since then, the handsets became the talk of the time. Now the company is all set to attract more customers as it has decided to launch an affordable variant of Samsung Galaxy S23 FE in the country.

Ahead of the official launch, many information such as specs, design leaked on digital platforms, claiming the handset might come with the latest processor with a 120 Hz AMOLE display that will allow users to have a high-definition experience while playing videos or using the phone. As per the leaks, the phone could be equipped with a flagship chipset launched by Qualcomm last year. However, the South Korean tech giant hasn’t revealed anything regarding the same as of now. Not even the price and launch date.

Once launched, interested customers can purchase the smartphone from the company’s authorized store. If one wants it at an additional discount, they can purchase the phone from the e-commerce giant Amazon or Flipkart.

Know everything about Samsung Galaxy S21 FE

Tipster Connor (@OreXda) claims that the Samsung Galaxy S23 FE will be powered by the Snapdragon 8+ Gen 1 processor. It is the second most powerful chipset from Qualcomm after Snapdragon 8 Gen 2. A lot of flagship phones of this year shared the with same Snapdragon 8 Gen 1 such as OnePlus 11R, Xiaomi 12S Ultra, Asus Zenfone 9, Samsung Galaxy Z Flip 4, and Oppo Find N2 among others.

It said that the upcoming Samsung Galaxy S21 FE might replace the company’s feature-loaded smartphone Galaxy A74. It is expected that the company likely to launch the S21 FE at a similar price as A74.


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