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Indian scientists testing dendritic therapy against cervix cancer

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Indian scientists testing dendritic therapy against cervix cancer

By Dr. TV Venkateswaran and Jyoti Singh

Researchers at the National Institute of Immunology (NII) have identified a tumour antigen that promises to be a potent weapon in combating cervical cancer

New Delhi: Cancer of the uterine cervix, also known as cervical cancer, is the second leading cause of cancer deaths among women in India. Almost one lakh women fall victim to the insidious disease every year in the country.

Researchers at the New Delhi-based National Institute of Immunology (NII) are in the process of fine tuning a solution that promises to add a highly potent weapon to the armoury against this type of cancer. They have extracted and identified a tumour antigen which seems to hold a lot of promise. The antigen has been named SPAG9.

“The tumor antigen, which is expressed in reproductive tract cancers and a variety of malignancies, has proved successful in phase I trials. This means it has been proved to be safe on human subjects. Phase II clinical trials are presently underway to gauge its efficacy. We hope to get positive results by next year,” said Dr Anil Kumar Suri, NII director, in an interview.

The therapeutic vaccine based on the antigen is being tested among 54 patients at Cancer Institute (WIA) at Adyar in Chennai. The trials are being conducted by a team of oncologist led by Dr T. Rajkumar. If proven efficacious, it could change the face of cervix cancer treatment. The human trials are being conducted subsequent to elaborate trials with animal models.

Invasion of foreign bodies like bacteria or virus usually trigger a volley of fighter cells called T cells. These T cells surround germs and fight them. Each type of virus or bacteria requires specific antigen T cells. Vaccination primes the body to potential threats and keeps the arsenal of antigens ever ready to fight an invasion.

However, this cannot happen with cancer. Even though they are rogue elements, cancer cells are after all from within the affected persons themselves. Body’s immune system cannot normally recognize them as a ‘threat’. They, therefore, allow them to proliferate and spread all around the body.

Immunotherapy is a new approach that exploits body’s inner capability to put up a fight against cancer. Under the approach, either immune system is given a boost or the T cells are “trained’’ to identify recalcitrant cancer cells and kill them.

The NII scientists are using this strategy to develop the new weapon against cancer of the cervix.  “We take cells called monocytes from the patient’s blood and modify them into what are called dendritic cells. These cells have efficient antigens to stimulate the ‘fighter’ cells, or T-cells, in the body. They are then primed with the tumour antigen SPAG9, for ten days, and given back to the patients in the form of a vaccine. The ‘educated’ T cells are able to discriminate the cancer cells and put up a fight against them,” explained Dr Suri.

Poor health, malnutrition, unhygienic environment are the main cause of Human papillomavirus (HPV) infection that leads to cervical cancer. Normally our body has tumor suppressor genes and proteins which are able to suppress formation of tumours. The cells in a tumour multiply uncontrollably with hardly any cell death.

NII has outsourced the manufacture of recombinant SPAG9 to Syngene International (Biocon Limited), Bangalore. “If the trials succeed, it will be the first molecule identified in India and will be an example of translational research outcome. Our findings have opened new avenues for novel treatment modalities in battling the deadly disease of cancer worldwide,” said Dr Suri.

Dr. Suri graduated from Hans Raj College, Delhi University and after that did his post-graduation and doctorate from National Dairy Research Institute at Karnal. Subsequently, he did his post- doctorate from Laboratoire pour le contrôle des Reproducteurs, Maisons-Alfort, France. He returned to India in 1985 and joined NII as a scientist.

The thrust of his research is on early detection and diagnosis of cancer and development of targeted approaches for therapeutic interventions for cancer medicine.

Dr Suri has authored 63 high impact publications in reputed international journal and has 15 patents on novel immunotherapeutic method for cancer treatment and diagnosis in India and abroad. He has won the S.S. Guraya Memorial Award, Dr T C Anand Kumar Memorial Oration Award and Rabindra Nath Chakravarti Citation Award.

(This article is from a syndicated feed provided by the India Science Wire)

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OnePlus India CEO Robin Liu steps down, shutdown rumours resurface

OnePlus India confirms business continuity after CEO Robin Liu’s resignation sparks shutdown rumours online.

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The resignation of Robin Liu as India CEO of OnePlus has triggered fresh speculation online about the company’s future, even as the firm has firmly denied any plans to shut down operations.

Liu will step down from his role effective March 31, 2026. His exit comes months after he publicly dismissed similar rumours about the company withdrawing from certain markets.

Google searches spike after leadership exit

Following news of Liu’s departure, search trends for terms like “OnePlus shutdown”, “OnePlus shutting down”, and “OnePlus India shutdown” saw a noticeable surge, indicating rising public concern.

However, OnePlus India clarified that there is no change in its business operations and dismissed the shutdown claims as misinformation.

In a public statement, Liu said the company is “operating as usual” and urged stakeholders to rely on official sources rather than unverified reports. He reiterated that claims about the company shutting down are false.

Company says operations remain unchanged

The company stated that Liu’s decision to step down was due to personal reasons and not linked to any strategic withdrawal or operational challenges in India.

OnePlus further emphasized that its India business continues normally, with no immediate changes expected in its strategy or market presence.

Restructuring within OPPO group

Industry observers suggest Liu’s exit may be part of a broader restructuring within the OPPO group, which owns OnePlus.

The restructuring is believed to focus on streamlining operations, reducing costs, and accelerating product development amid challenges such as rising component costs and supply constraints.

Reports also indicate that OnePlus experienced a decline in shipments in 2025, which may have contributed to internal changes.

Reports hint at global strategy shift

According to a report by 9to5Google, the company may scale back its presence in some global markets, including parts of Europe, as early as April 2026.

At the same time, OnePlus is reportedly planning to strengthen its focus on India and expand further into the mid-range smartphone segment.

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Oppo K14 5G launched in India with 7000mAh battery, starts at Rs 17,999

Oppo has launched the K14 5G in India with a 7000mAh battery, fast charging and durability features, starting at Rs 17,999.

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oppo K14 5G

Oppo has launched its latest mid-range smartphone, the K14 5G, in India, positioning it as an “endurance powerhouse” with a strong focus on battery life, smooth performance and long-term reliability.

The smartphone starts at Rs 17,999 for the 6GB + 128GB variant, while the 6GB + 256GB and 8GB + 256GB models are priced at Rs 19,999 and Rs 21,999 respectively. It will be available for purchase starting March 20 via Flipkart and the company’s official online store. Buyers can also avail an instant discount of up to Rs 1,000 along with no-cost EMI options for up to three months.

Focus on battery life and endurance

A key highlight of the Oppo K14 5G is its 7000mAh battery, designed to support extended daily usage without frequent charging. The company claims the device can deliver up to 738.8 hours of standby time. It also supports long usage across activities such as voice calls, video streaming, navigation and messaging.

The device comes with 45W fast charging, which can charge the battery from 1 percent to 37 percent in around 30 minutes, with a full charge taking about 92 minutes. Oppo says the battery is engineered to maintain durability for up to five years. Reverse wired charging is also supported for added convenience.

Built for durability and everyday use

The smartphone is designed with durability in mind, featuring SGS 5-star certification and MIL-STD-810H military-grade testing. It has undergone multiple drop tests and transportation shock testing to ensure resistance against accidental falls and rough usage conditions.

The device also carries IP66, IP68 and IP69 ratings, offering protection against dust, water immersion and high-pressure water exposure. Additional features like water-repellent camera coating and glove and splash touch support further enhance usability in different environments.

Display and design

The Oppo K14 5G features a 6.75-inch display with a 120Hz refresh rate and brightness of up to 1125 nits in high brightness mode. It is available in three colour options — Icy Blue, Prism Violet and Prism White — with a matte finish and subtle reflective design elements.

Performance and cooling

Powered by the MediaTek Dimensity 6300 chipset, the smartphone is designed to handle everyday tasks such as browsing, streaming and multitasking efficiently. It runs on ColorOS 15, which includes system optimisation features aimed at maintaining smooth performance over time.

To manage heat during extended usage, the device includes a vapor chamber cooling system with graphite layers for improved thermal management. This helps maintain stable performance during gaming and heavy usage.

Camera and AI features

The smartphone is equipped with a 50MP main camera, supported by a 2MP monochrome sensor, along with an 8MP front camera. It offers AI-powered features such as portrait retouching, AI eraser, AI clarity enhancement and dual-view video recording.

These tools are designed to improve image quality, assist in editing and enhance overall photography experience for users.

Availability and after-sales support

The Oppo K14 5G will be available starting March 20 with launch offers including discounts and EMI options. The company is also offering a 30-day inspection and replacement policy in case of manufacturing defects, supported by its nationwide service network.

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OnePlus Freedom Sale 2026 brings discounts on 15, 15R, 13, Nord 5 and tablets

OnePlus Freedom Sale 2026 begins Jan 16 with discounts on phones, tablets, and audio products across online and offline stores.

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OnePlus has announced its Freedom Sale, offering discounts on smartphones, tablets, and audio products across online and offline platforms. The deals include the recently launched OnePlus 15 series, Nord lineup, Buds audio devices, and other gadgets.

When and where to shop

The OnePlus Freedom Sale starts on Jan. 16 and will run both online and offline. Shoppers can purchase smartphones through OnePlus.in, OnePlus Experience Stores, Amazon, as well as offline retailers including Croma, Reliance Digital, Vijay Sales, and others. Tablets are available on Flipkart during the sale period.

Discounts on OnePlus smartphones

  • OnePlus 15: Launched at Rs 72,999, buyers can get an instant Rs 4,000 discount, lowering the effective price to Rs 68,999. Additional benefits include six months of no-cost EMI and a bundled OnePlus Nord Buds 3.
  • OnePlus 13: Originally priced at Rs 69,999, the phone receives an Rs 8,000 price drop, plus a bank discount of Rs 4,000, bringing the price down to Rs 57,999.
  • OnePlus 15R: Listed at Rs 47,999, buyers can avail Rs 3,000 off until Jan 26. After the date, the effective price is Rs 45,999.
  • OnePlus 13R: Launched at Rs 42,999, this device gets up to Rs 6,000 price cut and an additional Rs 1,000 bank discount.

Discounts on OnePlus tablets

  • OnePlus Pad 2: Rs 2,000 instant bank discount reduces the price to Rs 34,999.
  • OnePlus Pad 3: Eligible for a Rs 3,000 instant discount, making the price Rs 44,999. Purchases until Jan 26 include a free Stylo 2 stylus.
  • OnePlus Pad Go 2: Rs 1,000 price drop plus Rs 2,000 bank discount, now Rs 23,999.
  • OnePlus Pad Go: Price reduced to Rs 13,999 after Rs 3,000 cut and Rs 1,000 bank discount.
  • OnePlus Pad Lite: Available for Rs 11,999 after a Rs 2,000 price drop and Rs 2,000 bank discount.

Audio devices on offer

  • OnePlus Buds 4: Rs 700 price cut with Rs 300 bank discount, bringing the effective price to Rs 4,999.
  • OnePlus Buds Pro 3: Now Rs 9,999 after Rs 1,000 price drop and Rs 1,000 bank discount. No-cost EMI options are available for both Buds 4 and Buds Pro 3.

Additional discounts are also applicable to the Nord Buds series — including Nord Buds 3, Nord Buds 3 Pro, and Nord Buds 3R — and neckband devices such as Bullets Wireless Z2 ANC and Bullets Wireless Z3.

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