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New strategy proposed to make breast cancer therapy effective

Published

9 years ago

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[vc_row][vc_column][vc_column_text]Dr. Shikha T. Malik

Scientists have identified mechanisms that make breast cancer stem cells resistant to chemotherapy says a study published in the Scientific Reports journal

New Delhi: A group of Indian scientists have proposed a new strategy to make chemotherapy for triple negative breast cancer more effective.

Scientists at the University of Calcutta and the Saroj Gupta Cancer Care and Research Institute (SGCC&RI), Kolkata, have identified mechanisms that make breast cancer stem cells resistant to chemotherapy. This knowledge, they say, can be used to develop combination therapy along with conventional drugs to tackle aggressive triple negative breast cancer (TNBC). The study results have been published in journal Scientific Reports.

Breast cancer threatens one in every 28 urban women in India. TNBC is a subset of breast cancer which is resistant to most drugs and tends to recur once drug therapy is stopped. It is also aggressive and spreads easily. TNBC patients are generally given intense cycles of chemotherapy in addition to radiation. Clinical studies have shown that TNBC evolves prominently, especially in patients from West Bengal and Bangladesh.

Breast cancer stem cells are resistant to drugs, live longer and proliferate once chemotherapy ends. “This is because elevated expression of drug efflux pumps that throw out the drug from cells,” explained Pritha Mukherjee, a member of the research team.

In this process, the study has found that three molecules – SOX2, ABCG2, and TWIST1 – play an important role. The researchers have further showed that on shutting down SOX2 (which further affects TWIST1 also) and treatment with anti-cancer drug, paclitaxel, restricted migration of cancer stem cells. Even after removal of the drug, these cells did not migrate. “This means obliterating SOX2 expression specifically in breast cancer stem cells before or during chemotherapy is a possible approach to eliminate their population within a tumour, with a promise to prevent post-chemotherapy recurrences,” said Prof Urmi Chatterji of University of Calcutta.

The outcome of this basic understanding may be translated into a clinical method for controlling tumor recurrence. “A treatment strategy which ensures eradication of persistent drug resistant cells would serve as a complete therapy,” Dr Arnab Gupta, Director, SGCC&RI, told India Science Wire.

“Designing new methods which would target SOX2 would in effect render resistant cell population sensitive to anti-cancer drugs,” suggested Prof Dhrubajyoti Chattopadhyay, Vice Chancellor, Amity University, a co-author of the study.

“Further research in our lab by Dr Sreemanti Das has identified nanoformulation of anti-cancer drugs which have the potential to reduce SOX2 expression and effectively obliterate the cancer stem cell population in cells-in-culture as well as in tumors induced in mice. It has immense potential in being developed as a promising drug in future,” added Prof Chatterji. However, detailed clinical studies are needed to translate this research into treatment.

The research team included Dr Urmi Chatterji, Pritha Mukherjee, Dr Arnab Gupta, and Dr Dhrubajyoti Chattopadhyay. The study was funded by Department of Biotechnology.

(This article is from a syndicated feed provided by the India Science Wire)[/vc_column_text][/vc_column][/vc_row]

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OnePlus India CEO Robin Liu steps down, shutdown rumours resurface

OnePlus India confirms business continuity after CEO Robin Liu’s resignation sparks shutdown rumours online.

Published

3 weeks ago

on

March 26, 2026

By

The resignation of Robin Liu as India CEO of OnePlus has triggered fresh speculation online about the company’s future, even as the firm has firmly denied any plans to shut down operations.

Liu will step down from his role effective March 31, 2026. His exit comes months after he publicly dismissed similar rumours about the company withdrawing from certain markets.

Google searches spike after leadership exit

Following news of Liu’s departure, search trends for terms like “OnePlus shutdown”, “OnePlus shutting down”, and “OnePlus India shutdown” saw a noticeable surge, indicating rising public concern.

However, OnePlus India clarified that there is no change in its business operations and dismissed the shutdown claims as misinformation.

In a public statement, Liu said the company is “operating as usual” and urged stakeholders to rely on official sources rather than unverified reports. He reiterated that claims about the company shutting down are false.

Company says operations remain unchanged

The company stated that Liu’s decision to step down was due to personal reasons and not linked to any strategic withdrawal or operational challenges in India.

OnePlus further emphasized that its India business continues normally, with no immediate changes expected in its strategy or market presence.

Restructuring within OPPO group

Industry observers suggest Liu’s exit may be part of a broader restructuring within the OPPO group, which owns OnePlus.

The restructuring is believed to focus on streamlining operations, reducing costs, and accelerating product development amid challenges such as rising component costs and supply constraints.

Reports also indicate that OnePlus experienced a decline in shipments in 2025, which may have contributed to internal changes.

Reports hint at global strategy shift

According to a report by 9to5Google, the company may scale back its presence in some global markets, including parts of Europe, as early as April 2026.

At the same time, OnePlus is reportedly planning to strengthen its focus on India and expand further into the mid-range smartphone segment.

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Oppo K14 5G launched in India with 7000mAh battery, starts at Rs 17,999

Oppo has launched the K14 5G in India with a 7000mAh battery, fast charging and durability features, starting at Rs 17,999.

Published

4 weeks ago

on

March 20, 2026

By

oppo K14 5G

Oppo has launched its latest mid-range smartphone, the K14 5G, in India, positioning it as an “endurance powerhouse” with a strong focus on battery life, smooth performance and long-term reliability.

The smartphone starts at Rs 17,999 for the 6GB + 128GB variant, while the 6GB + 256GB and 8GB + 256GB models are priced at Rs 19,999 and Rs 21,999 respectively. It will be available for purchase starting March 20 via Flipkart and the company’s official online store. Buyers can also avail an instant discount of up to Rs 1,000 along with no-cost EMI options for up to three months.

Focus on battery life and endurance

A key highlight of the Oppo K14 5G is its 7000mAh battery, designed to support extended daily usage without frequent charging. The company claims the device can deliver up to 738.8 hours of standby time. It also supports long usage across activities such as voice calls, video streaming, navigation and messaging.

The device comes with 45W fast charging, which can charge the battery from 1 percent to 37 percent in around 30 minutes, with a full charge taking about 92 minutes. Oppo says the battery is engineered to maintain durability for up to five years. Reverse wired charging is also supported for added convenience.

Built for durability and everyday use

The smartphone is designed with durability in mind, featuring SGS 5-star certification and MIL-STD-810H military-grade testing. It has undergone multiple drop tests and transportation shock testing to ensure resistance against accidental falls and rough usage conditions.

The device also carries IP66, IP68 and IP69 ratings, offering protection against dust, water immersion and high-pressure water exposure. Additional features like water-repellent camera coating and glove and splash touch support further enhance usability in different environments.

Display and design

The Oppo K14 5G features a 6.75-inch display with a 120Hz refresh rate and brightness of up to 1125 nits in high brightness mode. It is available in three colour options — Icy Blue, Prism Violet and Prism White — with a matte finish and subtle reflective design elements.

Performance and cooling

Powered by the MediaTek Dimensity 6300 chipset, the smartphone is designed to handle everyday tasks such as browsing, streaming and multitasking efficiently. It runs on ColorOS 15, which includes system optimisation features aimed at maintaining smooth performance over time.

To manage heat during extended usage, the device includes a vapor chamber cooling system with graphite layers for improved thermal management. This helps maintain stable performance during gaming and heavy usage.

Camera and AI features

The smartphone is equipped with a 50MP main camera, supported by a 2MP monochrome sensor, along with an 8MP front camera. It offers AI-powered features such as portrait retouching, AI eraser, AI clarity enhancement and dual-view video recording.

These tools are designed to improve image quality, assist in editing and enhance overall photography experience for users.

Availability and after-sales support

The Oppo K14 5G will be available starting March 20 with launch offers including discounts and EMI options. The company is also offering a 30-day inspection and replacement policy in case of manufacturing defects, supported by its nationwide service network.

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OnePlus Freedom Sale 2026 brings discounts on 15, 15R, 13, Nord 5 and tablets

OnePlus Freedom Sale 2026 begins Jan 16 with discounts on phones, tablets, and audio products across online and offline stores.

Published

3 months ago

on

January 13, 2026

By

OnePlus has announced its Freedom Sale, offering discounts on smartphones, tablets, and audio products across online and offline platforms. The deals include the recently launched OnePlus 15 series, Nord lineup, Buds audio devices, and other gadgets.

When and where to shop

The OnePlus Freedom Sale starts on Jan. 16 and will run both online and offline. Shoppers can purchase smartphones through OnePlus.in, OnePlus Experience Stores, Amazon, as well as offline retailers including Croma, Reliance Digital, Vijay Sales, and others. Tablets are available on Flipkart during the sale period.

Discounts on OnePlus smartphones

  • OnePlus 15: Launched at Rs 72,999, buyers can get an instant Rs 4,000 discount, lowering the effective price to Rs 68,999. Additional benefits include six months of no-cost EMI and a bundled OnePlus Nord Buds 3.
  • OnePlus 13: Originally priced at Rs 69,999, the phone receives an Rs 8,000 price drop, plus a bank discount of Rs 4,000, bringing the price down to Rs 57,999.
  • OnePlus 15R: Listed at Rs 47,999, buyers can avail Rs 3,000 off until Jan 26. After the date, the effective price is Rs 45,999.
  • OnePlus 13R: Launched at Rs 42,999, this device gets up to Rs 6,000 price cut and an additional Rs 1,000 bank discount.

Discounts on OnePlus tablets

  • OnePlus Pad 2: Rs 2,000 instant bank discount reduces the price to Rs 34,999.
  • OnePlus Pad 3: Eligible for a Rs 3,000 instant discount, making the price Rs 44,999. Purchases until Jan 26 include a free Stylo 2 stylus.
  • OnePlus Pad Go 2: Rs 1,000 price drop plus Rs 2,000 bank discount, now Rs 23,999.
  • OnePlus Pad Go: Price reduced to Rs 13,999 after Rs 3,000 cut and Rs 1,000 bank discount.
  • OnePlus Pad Lite: Available for Rs 11,999 after a Rs 2,000 price drop and Rs 2,000 bank discount.

Audio devices on offer

  • OnePlus Buds 4: Rs 700 price cut with Rs 300 bank discount, bringing the effective price to Rs 4,999.
  • OnePlus Buds Pro 3: Now Rs 9,999 after Rs 1,000 price drop and Rs 1,000 bank discount. No-cost EMI options are available for both Buds 4 and Buds Pro 3.

Additional discounts are also applicable to the Nord Buds series — including Nord Buds 3, Nord Buds 3 Pro, and Nord Buds 3R — and neckband devices such as Bullets Wireless Z2 ANC and Bullets Wireless Z3.

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