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Scientists decipher why epilepsy drugs don’t work for some women

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Scientists decipher why epilepsy drugs don’t work for some women

[vc_row][vc_column][vc_column_text]By BhavyaKhullar
Twitter- BhavyaSc

New Delhi, June 13 (India Science Wire): Effective treatment is available for epilepsy, yet doctors find that epilepsy drugs don’t work in some women. Now scientists have figured out why some women suffer from recurrent seizures despite medication.

Scientists at Institute of Genomics and Integrative Biology (IGIB) and Institute of Human Behavior and Allied Sciences (IHBAS), both in New Delhi, have found that a variation in a gene called Cytochrome P4501A1 (CYP1A1) is responsible for some women continuing to suffer from frequent epileptic seizures despite taking one or a combination of known anti-epileptic drugs.  The study results have been published in The Pharmacogenomics Journal.

CYP1A1 gene is known to make an enzyme, that regulates the levels of female hormone estrogen in the blood, which is also important in controlling drug response in epilepsy.“Since this gene is involved in dispersal of estrogen, we thought that perhaps an altered expression of it is contributing to higher levels of estradiol, which, in turn, was increasing susceptibility of women to seizure and causing poor response to drugs. Our studies showed this was indeed so,” researchers explained. The study involved 579 patients with epilepsy, of whom 45% were women.

Based on the study results, the researchers have identified a genetic marker for predicting therapeutic response to drugs in epilepsy.

“Though genetic variation has been studied in other countries with variable results, this study in the Indian context is important. We still are trying to find out best management for intractable seizure. Hopefully the new finding about genetic basis of intractable seizures will lead to some better enzyme regulation in anti-epileptic drugs in future,” commented DrVijayaNath Mishra, professor of neurology at the Institute of Medical Sciences (IMS) BHU, who was not involved in this study.

The research team included P Talwar, N Kanojia, S Mahendru, R Baghel, S Grover, G Arora, GK Grewal, S Parween, A Srivastava, M Singh, S Vig, S Kushwaha, S Sharma, K Bala, S Kukreti, and RitushreeKukreti.  (India Science Wire)[/vc_column_text][/vc_column][/vc_row]

2024 Lok Sabha Elections

PM Modi says Congress leaders consider themselves above Lord Ram

PM Modi slammed Congress during a rally in Chhattisgarh, ahead of the Lok Sabha elections 2024

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Prime Minister Narendra Modi slammed the Congress party for declining to attend the pran pratishtha ritual at the Ayodhya Ram temple on January 22 this year.

The prime minister said Congress leaders consider themselves above Lord Ram and denied invitation for Pran Pratishtha at Ram Temple, while speaking at a rally in Janjgir-Champa, Chhattisgarh. The PM question the people present at the rally that is it not a disrespect of Mata Shabri? Congress leaders inclination toward appeasement politics runs in their family.

For political appeasement, they won’t think twice about stealing the rights of Adivasis, the poor, and Dalits. Poor, young, and women are BJP’s top priorities, Modi said.

PM Modi criticized the Congress again during the rally for claiming that the BJP would alter the constitution.

The leaders of Congress recite the same old phrases whenever an election is about to happen, the PM said. He also said they claim that if the BJP wins power, it will renounce the constitution and abolish reservations. For how long will you continue selling lies?” he asked.

The prime minister continued saying that nobody can change the Constitution, even if Dr. Babasaheb Ambedkar were to come and insist on it, it wouldn’t happen.

Those in the Congress threaten to break Modi’s head. Nobody can harm Modi as long as the mothers and sisters of this county stands by him. These mothers and sisters are Raksha Kavach, Modi remarked.

The prime minister further attacked the Congress after Viriato Fernandes, the party’s candidate for South Goa, asserted that Goa was forced to adopt the Indian Constitution.

Referring to his conversation with Congress leader Rahul Gandhi ahead of the 2019 Lok Sabha elections, Fernandes said he had told him, when Goa was liberated in the year 1961, the Indian Constitution was forced upon us.

The prime minister said, Congress candidate from Goa says Constitution was forced upon Goans; is this not an insult of Ambedkar and Constitution.

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2024 Lok Sabha Elections

Amit Shah says neither Congress nor Trinamool chief Mamata Banerjee can interfere with CAA

Amit Shah revealed the BJP’s target for West Bengal and said they have set a target of winning 35 Lok Sabha seats from West Bengal.

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Union home minister Amit Shah on Tuesday said neither Congress nor Trinamool Congress chief Mamata Banerjee can interfere with the Citizenship Amendment Act (CAA). He was speaking at the Karandighi rally in West Bengal where he also made the prediction as to how many seats BJP will win in the Lok Sabha elections in West Bengal.

The union home minister asked the masses to cut the money culture. Amit Shah revealed the BJP’s target for West Bengal and said they have set a target of winning 35 Lok Sabha seats from West Bengal. In 2019 Lok Sabha elections the BJP had won 18 out of 42 seats in West Bengal. He asked Mamata Banerjee, what problem will she have if the Buddhist and Hindu refugees from Bangladesh get citizenship in India?

Shah further added if the people of West Bengal want to stop infiltration in the state, then they will have to make Narendra Modi the Prime Minister of India again. He said if the people of West Bengal want to free Bengal of violence, stop infiltration in the state, give citizenship to refugees, to stop disrespecting mothers and sisters of the state as it happened in Sandeshkhali, then  only way is to make Narendra Modi the Prime Minister.

Amit Shah said that PM Modi had sent Rs 7 lakh crore to West Bengal but the TMC indulged in corruption. He said one can see the houses of Trinamool Congress leaders; 10 years ago they used to live in a hut, moved on cycle and now all of them have 4-storey houses and move around in big cars. He added this is the money of people of West Bengal.

The Citizenship Amendment Act (CAA), will make it easier for non-Muslim refugees from Afghanistan, Pakistan and Bangladesh to get Indian citizenship, was enacted in 2019. But the rules were notified in March this year by the Centre.

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2024 Lok Sabha Elections

Prime Minister Narendra Modi says listening to Hanuman Chalisa under Congress rule is a crime

PM Modi was addressing an election rally in Rajasthan’s Tonk-Sawai Madhopur, on a day as India celebrates Hanuman Jayanti.

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Prime Minister Narendra Modi on Tuesday hit out at the Congress and said even listening to Hanuman Chalisa has become a crime under the party’s rule. The Prime Minister also said it was difficult to follow one’s faith under the party and accused it of hatching a deep conspiracy to snatch people’s wealth and distribute it among selected few people in the society. PM Modi was addressing an election rally in Rajasthan’s Tonk-Sawai Madhopur, on a day as India celebrates Hanuman Jayanti.

PM Modi said in a state like Rajasthan where people chant Ram-Ram, Congress banned Ram Navami. He reffered to the redistribution of wealth remarks he had made during a rally in Rajasthan’s Banswara on Sunday and said it has angered the Congress and INDI Alliance so much that they have started throwing abuses at Modi everywhere.

The Prime Minister said that Congress has written in their manifesto that they will survey the wealth. He said the Congress leadership had said in a speech that an X-ray of wealth will be done. He added when Modi exposed the secret then the hidden agenda came out and this has left the people trembling. PM Modi further added that the Congress party has played with the Constitution of the India.

He said when the Constitution was drafted, reservations based on religion were opposed, so that Scheduled Casts (SC), Scheduled Tribes (ST) and Other Backward Classes (OBC) could get protection. He said former Prime Minister Dr Manmohan Singh had said that Muslims have the first right to the country’s resources.  The prime minister further added Congress’s ideology has always been of appeasement and vote bank politics. He said stones would still be pelted in Jammu and Kashmir, and enemies would still be cutting off the heads of India’s soldiers had Congress been in power.

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