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Amid surge in black fungus cases, pharma companies to increase production of Amphotericin B injection

The industry source hinted that it would take at least 15-30 days for new production to enter the market, as the drug is complex to manufacture and would require a certain number of days of sterility data before the batch is released.

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black fungus patient

Keeping in mind the increasing demand of anti-fungal drug Amphotericin B injection after several states has reported surge in black fungus cases across the country, the Pharma companies are scrambling to ramp up the production of antifungal drug. Though there are few cases of Black Fungus in the country, at 140 per million people, but the mortality rate is high 38 percent.

The industry source hinted that it would take at least 15-30 days for new production to enter the market, as the drug is complex to manufacture and would require a certain number of days of sterility data before the batch is released.

Sun Pharma spokesperson reportedly said there has been a sudden increase in demand for Liposomal Amphotericin B in India due to the rising cases of mucormycosis. The spokesperson said they have ramped up the production of Lambin 50 injection (Liposomal Amphotericin B) to meet the additional demand. He also said that the company is confident of increasing the production rapidly.

Amphotericin B is the primary drug required to treat cases of black fungus that damages the nose, eyes, sinuses and sometimes even the brain. In normal times there was no demand for the product. So, the companies were manufacturing only in limited quantities not exceeding tens of thousands of vials.

Another major supplier Serums and Vaccines (BSV) said that the primary focus of the company is to address the current demand for Liposomal Amphotericin B in the country due to rising fungal infection cases. The company is in touch with doctors, hospitals and stockists to meet the requirements and provide timely support. The BSV said the company is working with the government and suppliers of raw materials to expand production.

The shortages have also led to hoarding and black marketing of the drug, where the prices are quoted at 5-10 times the maximum retail price. Shortages and soaring prices in the black market have pressed the Centre and state governments into action.

Minister of State for Chemicals and Fertilisers Mansukh Mandaviya on May 18 reviewed the requirement and supply position of Amphotericin B. He said the government has chalked out a strategy with manufacturers to increase domestic production as well as to import the drug from all over the world, and assured that the shortage is expected to be resolved at the earliest.

Doctors have noted a surge in cases of black fungus amid patients who were hospitalised and recovering from Covid-19, leading to an increase in the demand for Amphotericin B. With several states like Delhi, Maharashtra, Gujarat and Karnataka reporting a shortage in the drug’s supply, people have once again turned to Twitter in an attempt to crowdsource the antifungal medicine.

Moneycontrol reported that Hospitals are reporting 10-15 times more cases over normal times. Experts have noted that prolonged use of steroids, those afflicted with diabetes and with reduced-immunity are at a higher risk of contracting the disease.

Read Also: Very heavy rain likely in some parts of Delhi, India Meteorogical Department issues orange alert

Earlier, the twitter has been flooded with SOS messages about the need of Remdesivir and Tocilizumab, have now added another drug to the list, ‘Amphotericin B’, an antifungal medicine.

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Man attempting to cross India-Pakistan border in Rajasthan shot dead by BSF personnel

“We are investigating the case under these acts,” he added.

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Border Security Force (BSF) personnel shot and killed an individual attempting to cross the India-Pakistan border in the Ganganagar district of Rajasthan late on Tuesday, according to police.

Jitendra Kumar, the station house officer at Kesrisinghpur police station, stated that the man was trying to breach the barbed wire fence when he was spotted by BSF personnel. “They advised him to leave the area, but when he continued to advance, the BSF personnel shot him,” said the SHO.

Sriganganagar Superintendent of Police Gaurav Yadav confirmed that the suspect was allegedly trying to enter Indian territory around midnight on December 24, 2024. Despite warnings from the BSF soldiers, he did not heed their calls, which resulted in the shooting.

The incident occurred near a village in the Kesarisinghpur area. Items recovered from the intruder included Pakistani currency notes, a cigarette packet, an identity card, and other belongings. Authorities are currently gathering more information about him.

Ongoing discussions are taking place between the armed forces and police officers regarding the incident. An FIR has been filed that includes charges of trespassing and violations of the Passports Act and the Foreigners Act, according to Kumar. “We are investigating the case under these acts,” he added.

This incident is one of several similar occurrences along the border. In August, the BSF apprehended an intruder named Jagsi Kohli, who had entered about 15 kilometers into Indian territory in Barmer after locals alerted authorities that he was asking for directions to Tharparkar, a district in Pakistan’s Sindh province.

In March of this year, another person attempting to cross the border in Ganganagar was shot by BSF personnel. There have been additional incidents reported in October 2022 and twice in March 2021, all resulting in fatalities among the intruders.

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Amit Shah, JP Nadda, Chandrababu Naidu among leaders at NDA meet in Delhi amid Ambedkar row

The alliance had decided to convene on the birthday of the late BJP leader, noted for successfully leading the first coalition government to complete its term.

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Union Home Minister Amit Shah, BJP chief J.P. Nadda and Telugu Desam Party (TDP) president and Andhra Pradesh Chief Minister Chandrababu Naidu among leaders of the NDA met in New Delhi on Wednesday to discuss different issues including Shah’s comment on BR Ambedkar days ago in Rajya Sabha.

In attendance, apart from Shah, Nadda and Naidu, JD-U leader and Union minister Rajiv Ranjan Singh, Apna Dal (S) president and Union minister Anupriya Patel, as well as JD (S) leader and Union minister H.D. Kumaraswamy were present.

Also present were Jitan Ram Manjhi, leader of Bihar’s Hindustani Awam Morcha (S) and a minister in the Modi government, Rashtriya Lok Morcha (RLM) president Upendra Kushwaha, a Rajya Sabha MP, and Thushar Vellappally, president of Bharath Dharma Jana Sena.

While the specific agenda of the meeting was not officially disclosed, sources indicated that discussions revolved around good governance and various political issues—principles that were central to Vajpayee’s tenure as Prime Minister. The alliance had decided to convene on the birthday of the late BJP leader, noted for successfully leading the first coalition government to complete its term.

Following the meeting, Nadda shared on X, “Attended the NDA leaders’ meeting in New Delhi today. Under the visionary leadership of PM Narendra Modi, India is achieving unprecedented milestones and has positioned itself as a global superpower. The NDA government remains committed to realizing the vision of ‘Viksit Bharat@2047’, ensuring a brighter and more prosperous future for all.”

Sanjay Nishad, chief of the NISHAD Party in Uttar Pradesh, described the meeting as “informal” and focused on Vajpayee’s legacy. He emphasised the importance of unity among all alliance members heading into future elections, mentioning that they congratulated the BJP leaders for their electoral victories in Haryana and Maharashtra.

Nishad further outlined that the meeting addressed coalition strategies to ensure that Prime Minister Modi’s initiatives effectively reach the populace and that electoral promises are fulfilled. He raised the topic of providing reservations for the fishing community, stating, “I presented evidence on this issue, as it was a poll promise. They will follow up with us next week to discuss it.”

Responding to inquiries about whether Amit Shah’s controversial remarks on Ambedkar were discussed, Nishad said, “We are here for the welfare of the people. Our energy should focus on achieving success in that area, rather than engaging with negativity from opposition parties.”

The NDA meeting underscores the alliance’s commitment to the proposed simultaneous elections, with all members backing the initiative. A Joint Committee of Parliament, established to review two bills related to simultaneous polls, is set to convene on January 8.

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Manipur CM Biren Singh says state needs immediate peace, understanding between two communities

He claimed that the administration is responding quickly to the displaced people’s needs in areas such as education and agriculture.

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Manipur Chief Minister N Biren Singh on Wednesday emphasised the urgent need for peace in the state, which has faced ethnic violence since May of last year, and called on two communities to reach a mutual understanding.

Speaking at the Good Governance Day event held at the state BJP headquarters, Singh expressed confidence that the BJP could restore stability to the northeastern state, highlighting the party’s commitment to coexisting harmoniously.

“What is happening in Manipur today has multiple causes. Those who seek to divide the state are now questioning the government’s actions… they are driven by a desire for power,” Singh remarked.

He mentioned several initiatives, such as ‘Meeyamgi Numit’ (People’s Day), designed to foster closer relationships between officials and the public. “We do not oppose any specific community. The BJP’s position is clear: we advocate for the idea of living together and have initiated efforts to strengthen ties between the police and the community,” he stated.

Singh added that the state government is diligently addressing the needs of internally displaced persons by establishing committees throughout the administrative framework. He claimed that the administration is responding quickly to the displaced people’s needs in areas such as education and agriculture.

“We have not made any mistakes. Our goal is to ensure the well-being of future generations. It is essential for both communities to remain calm. Rather than dwelling on the past, we should concentrate on the upcoming NRC process, capturing biometrics, and using 1961 as the foundation year for the Inner Line Permit,” Singh said.

He also highlighted the government’s commitment to acting within a democratic and constitutional framework, noting that achieving these goals will take time. “What we require now is immediate peace and a resolution of misunderstandings between the two communities,” he concluded.

The ongoing violence has resulted in the deaths of over 250 individuals and left thousands homeless due to clashes between the Meitei community and Kuki-Zo groups since last May.

“Only the BJP can save Manipur. BJP leaders possess strong values of nationalism and social justice, practicing reality-based politics in the nation’s interest. If I am not nominated for a ticket by the BJP, I will remain loyal to the party,” Mr. Singh added.

He also highlighted several unity-focused projects initiated by the BJP government, mentioning that a Unity Mall featuring stalls from all ethnic groups in the state will be constructed with an investment exceeding ₹140 crores.

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