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Zydus Cadila’s ZyCoV-D, world’s first needle-free DNA based vaccine for children aged 12 and above gets clearance in India

Zydus Cadila’s vaccine, ZyCoV-D, has received approval for emergency use in India and it will be administered to people 12 years and above. The DNA-based vaccine will be the sixth vaccine to receive authorisation for emergency use in the India.

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India’s drug regulator on Friday granted emergency use approval to Zydus Cadila’s India-developed three dose Covid vaccine ZyCoV-D, the world’s first DNA Covid shot that will be administered to children above 12 years and adults.

On July 1, the Cadila Healthcare Ltd had applied for the authorisation of ZyCoV-D based on 66.6 % efficacy rate in a late-stage trial of over 28,000 volunteers nationwide.

The delivery of vaccines is likely to begin by next month-end and around five crore doses will be in India by December, a senior official said.

ZyCoV, developed in partnership with the Department of Biotechnology, is the second home-grown shot to get emergency authorisation in India after Bharat Biotech’s Covaxin.

The DNA-based vaccine will be the sixth vaccine to receive authorisation for emergency use in the India.

The DNA based bases vaccines have broadly three advantages. First, it is a needle-free vaccine system resulting reduction in side-effects such as pain at the injection site. Second, unlike m-RNA vaccines, which need ultra-cold storage systems, the DNA vaccines can be stored at 2-8 degrees Celsius that is best suited for India’s cold storage requirement. Third, the vaccine manufacturing facility does not require the setting up of BSL-3 high containment facility as is required in the production of inactivated virus vaccines like Covaxin.

With ZyCovD, India has now approved six vaccines. Two of them from AstraZeneca and one from Hyderabad-based Bharat Biotech are already being used in the government’s vaccination drive across the country. Russia’s Sputnik V has been administered in small numbers and Johnson & Johnson and Moderna are negotiating for legal indemnity.

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Among the other vaccines in use in India, Covaxin’s overall efficacy is 77.8% while Covishield has a proven efficacy of 70% in India. Sputnik V demonstrates 97.6% efficacy.

Earlier in 2010, Zydus had become the first company to develop and indigenously manufacture a vaccine against swine flu. Earlier, the company had developed the tetravalent seasonal influenza vaccine and the inactivated rabies vaccine.

In other India News, The Gujarat Board of Secondary and Higher Education (GSEB) result has been declared. 

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Over 5,000 tribals join BJP in Assam’s Goalpara ahead of elections

More than 5,000 tribals, largely from the Garo community, joined the BJP in Assam’s Goalpara district during a large-scale ST Morcha programme ahead of elections.

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More than 5,000 members of tribal communities formally joined the Bharatiya Janata Party (BJP) at a large-scale event held in Assam’s Goalpara district on February 25, weeks before key elections.

The joining programme was organised by the BJP ST Morcha, Assam Pradesh, at the Agia School playground. The event was conducted under the leadership of Riya Sangma, State Secretary of BJP ST Morcha and in-charge of the Goalpara ST Morcha.

Party leaders said the programme witnessed strong participation, particularly from the Garo community, describing it as a significant political development in the district.

The chief guest at the event was Samir Oran, National President of BJP ST Morcha and outgoing Member of Parliament (Rajya Sabha). Among those present were Bijuli Kalita Medhi, MP from the Guwahati Lok Sabha constituency, Ravindra Raju, Horen Singh Bey, who serves as State President of BJP ST Morcha, and other party leaders.

Goalpara district has traditionally seen strong influence from opposition parties, especially the Congress. Tribal voters in the region have largely remained divided, making the large-scale induction ahead of elections politically significant.

Addressing the media, Samir Oran said the BJP has brought a new phase of recognition and opportunity for tribal communities across the Northeast. He stated that the joining programme reflected growing trust among tribal populations in the party.

Riya Sangma said many tribal communities, particularly members of the Garo community, had earlier felt deprived of adequate respect and development benefits. She added that the participation of over 5,000 people demonstrated confidence in the BJP’s leadership.

Dipankar Nath, BJP Goalpara District President, termed the development a “game-changer” for the constituency. He said the party remains committed to the welfare, development and dignity of tribal communities.

Party leaders expressed confidence that the induction drive would strengthen the BJP’s organisational base in Goalpara and nearby areas ahead of the upcoming polls.

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PM Modi crosses 100 million followers on Instagram, first world leader to achieve milestone

Prime Minister Narendra Modi has crossed 100 million followers on Instagram, becoming the first world leader to achieve the milestone and widening the gap with global counterparts.

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Prime Minister Narendra Modi has become the first world leader and politician to cross 100 million followers on Instagram, marking a significant moment in global political communication.

Having joined the platform in 2014, the Prime Minister has steadily built one of the most followed political profiles worldwide. Over the past decade, his Instagram account has featured updates on official engagements, international visits, public outreach programmes, cultural highlights and personal moments, helping him connect with a broad and diverse audience.

With 100 million followers, PM Modi now ranks first among world leaders on Instagram. His follower count is more than double that of US President Donald Trump, who stands at 43.2 million followers.

Other prominent leaders remain considerably behind in comparison. Indonesian President Prabowo Subianto has around 15 million followers, Brazilian President Luiz Inacio Lula da Silva has 14.4 million, Turkish President Recep Tayyip Erdogan has 11.6 million, and Argentine President Javier Milei has 6.4 million followers.

Notably, the combined follower count of the next five major global leaders remains lower than PM Modi’s individual tally, highlighting the scale of his digital outreach. Observers note that his presence on Instagram resonates strongly with younger users in India and abroad, reflecting the growing importance of visual and interactive platforms in political engagement.

Wide gap within India’s political space

The Prime Minister also maintains a substantial lead over other Indian political figures on Instagram. Uttar Pradesh Chief Minister Yogi Adityanath has around 16.1 million followers, while Congress leader Rahul Gandhi has approximately 12.6 million followers.

The gap underlines PM Modi’s dominant position on social media among domestic political leaders.

The milestone reflects a broader global trend of political leaders increasingly using platforms like Instagram to communicate directly with citizens, share governance updates, and expand public engagement beyond traditional media channels.

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MK Stalin predicts frequent PM Modi visits to Tamil Nadu before assembly election

MK Stalin has said Prime Minister Narendra Modi will visit Tamil Nadu more often ahead of the Assembly election, calling the tours politically motivated and questioning the Centre’s support to the state.

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Tamil Nadu Chief Minister M. K. Stalin has predicted that Prime Minister Narendra Modi will increase his visits to the state as the Assembly election, expected in April or May, draws closer.

Speaking ahead of the polls, the DMK president said the Prime Minister has already begun touring Tamil Nadu and is likely to visit frequently in the coming months. He claimed that such visits could create discomfort within the BJP-led National Democratic Alliance (NDA), as alliance partners may fear the political impact of repeated appearances.

Stalin calls visit politically motivated

The Chief Minister described the Prime Minister’s scheduled programmes in the state as “politically motivated”. PM Modi is set to attend various events in Madurai in southern Tamil Nadu, including the inauguration of the first phase of the AIIMS hospital project. He is also expected to visit the Thiruparankundram Temple amid the Karthigai Deepam-related controversy and participate in a public meeting organised by the NDA.

Stalin said he has been working for all sections of the population, including those who did not vote for his party. In contrast, he remarked that some leaders are visible in the state only during election time and increase their visits as polls approach.

Criticism over Union Budget allocations

The DMK leader also criticised the BJP-led central government, accusing it of neglecting Tamil Nadu. He pointed out that while approval was recently granted for the Gujarat Metro project, there were no major announcements or allocations for Tamil Nadu in the Union Budget.

Stalin asserted that voters would remember the lack of significant measures for the state. He framed the upcoming election as a contest between Tamil Nadu and the NDA, stating that the state should be governed from Fort St George in Chennai rather than from Delhi.

The ruling DMK is currently allied with several smaller parties and, at present, the Congress, as it seeks a third consecutive term in office. Its principal rival, the AIADMK, is aligned with the BJP as part of the NDA.

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