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New TB drug may shorten treatment duration for patients

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New TB drug may shorten treatment duration for patients

[vc_row][vc_column][vc_column_text]A new experimental antibiotic for tuberculosis (TB) has been shown to be more effective against TB than Isoniazid, a decades old drug which is currently one of the standard treatments for the disease, finds a study on mice.

The new drug, called AN12855, has several advantages over Isoniazid as Isoniazid requires conversion to its active form by a Mycobacterial enzyme, KatG, in order to kill the pathogen, which creates some problems.

In some M. tuberculosis, KatG is nonfunctional. That does not make M. tuberculosis any less pathogenic, but it prevents the drug from working. Consequently, this creates an easy avenue for the development of drug resistance.

In the study, the new drug showed a much lower tendency to develop resistance, and it remains in the tissues where the Mycobacterium tuberculosis bacteria reside for longer, killing them more effectively.

The goal of TB drug development programmes is to develop universal treatment regimens that will shorten and simplify TB treatment in patients, which typically takes at least six months and sometimes more than a year, said lead author Gregory T. Robertson, Assistant Professor at the Colorado State University in Fort Collins in the US.

For the study, the researchers used a new TB mouse model that develops these M. tuberculosis-containing granulomas to compare Isoniazid and AN12855. Granuloma refers to a mass of granulation tissue, typically produced in response to infection, inflammation, or the presence of a foreign substance.

“We discovered that the drugs differed dramatically with respect to their abilities to kill the pathogen in highly diseased tissues,” said Robertson.  AN12855 proved more effective, “without selecting for appreciable drug resistance”, added Robertson in the study published in the journal Antimicrobial Agents and Chemotherapy.

Despite significant progress in combating tuberculosis, it remains the leading infectious cause of death worldwide, he said.  “Multidrug resistance is a further challenge to the mission to control TB globally. Collectively, our group has pioneered the use of new TB mouse efficacy models to help advance innovative new therapies designed to shorten the length of TB treatment.”

(Inputs from media reports)

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Lifestyle

Happy Friendship Day 2026: Heartwarming quotes and wishes to share on WhatsApp and Instagram

Friendship Day 2026 is being celebrated on August 2. Explore its history, significance and the best Friendship Day quotes and wishes to share on WhatsApp and Instagram.

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Friendship Day 2026 is being celebrated on Sunday, August 2, across India and several other countries where the occasion falls on the first Sunday of August. The day recognises the importance of friendship and celebrates the companionship, trust and support that friends bring into people’s lives.

As people mark the occasion, many are exchanging heartfelt wishes, messages and quotes on social media platforms such as WhatsApp and Instagram to express gratitude for their closest friends.

History and significance of Friendship Day

The idea of Friendship Day was first introduced in 1930 by Joyce Hall, the founder of Hallmark Cards. The concept was to dedicate August 2 as a day for people to appreciate their friends by sending greeting cards. Although the tradition initially became popular, its appeal later declined in the United States.

The movement gained wider recognition in 1958 when Dr Ramon Artemio Bracho proposed celebrating friendship during a gathering in Puerto Pinasco, Paraguay. His initiative resulted in the formation of the World Friendship Crusade, an organisation that promotes peace and friendship among people worldwide.

In 2011, the United Nations officially declared July 30 as the International Day of Friendship. However, countries such as India continue to celebrate Friendship Day on the first Sunday of August.

Best Friendship Day 2026 quotes and wishes

Here are some messages and quotes that can be shared with friends on WhatsApp or posted as Instagram status updates:

“Real friendship isn’t about being inseparable, but about being separated and nothing changes. Happy Friendship Day!”

“Friends are the family we choose. Happy Friendship Day!”

“Celebrating the people who make my world warmer. Happy Friendship Day!”

“Friendship isn’t about who you’ve known the longest. It’s about who stayed. Happy Friendship Day!”

“Happy Friendship Day! Here’s to the laughs, the memories, and the unbreakable bond we share.”

“Wishing you a Friendship Day filled with love, laughter, and lasting memories.”

“Cheers to all the crazy, wonderful times we’ve shared. Happy Friendship Day!”

“True friends are never apart, maybe in distance but never in heart. Happy Friendship Day!”

“Friendship is the greatest gift of life. Happy Friendship Day to all my dear friends!”

“To the one who has seen me at my best and stood by me at my worst—thank you for being my constant anchor. Happy Friendship Day 2026!”

“Distance might keep us apart, but real friendship doesn’t care about miles. Cheers to another year of shared memories and unconditional support. Happy Friendship Day!”

“Life is unpredictable, but having a friend like you makes every hurdle easier to cross. Happy Friendship Day!”

“Happy Friendship Day! Thanks for knowing all my weirdest habits and still choosing to be seen with me in public.”

“Happy Friendship Day! Here’s to another year of laughing at our own jokes and keeping each other’s embarrassing secrets!”

“Grateful for the ones who make quiet moments comfortable and crazy moments unforgettable. Happy Friendship Day!”

As people celebrate Friendship Day 2026, these heartfelt wishes continue to remind everyone of the enduring value of genuine friendships and the memories shared with those who stand by us through every stage of life.

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India News

Father’s Day 2026: date, history, significance and budget-friendly gift ideas for dads

Father’s Day 2026 falls on June 21. Learn about its history, significance, celebration traditions and affordable gift ideas to honour fathers and father figures.

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Father’s Day 2026 will be celebrated on Sunday, June 21, offering families an opportunity to honour fathers and father figures for their love, support, guidance and sacrifices. In India, as well as in several countries including the United States, the United Kingdom and Canada, the occasion is observed on the third Sunday of June every year.

The day is dedicated not only to fathers but also to grandfathers, stepfathers, guardians and mentors who play an important role in shaping lives and supporting families.

When is Father’s Day 2026?

Father’s Day 2026 falls on June 21, which is the third Sunday of June. The date changes each year, but the tradition of celebrating it on the third Sunday of June remains the same in many countries, including India.

History of Father’s Day

The modern observance of Father’s Day is widely linked to Sonora Smart Dodd of Spokane, Washington. Inspired by Mother’s Day celebrations, she wanted to honour her father, William Jackson Smart, a Civil War veteran who raised six children as a single parent after his wife’s death. Her efforts led to one of the earliest Father’s Day celebrations in Spokane on June 19, 1910.

Over the following decades, support for the observance grew across the United States. Father’s Day was officially recognised as a national holiday in 1972 when then-US President Richard Nixon signed a proclamation establishing it as an annual celebration.

Significance of Father’s Day

Father’s Day serves as a reminder to acknowledge the contribution of fathers and father figures in family life. The occasion recognises their role in providing emotional support, guidance, protection and encouragement. It is also an opportunity for families to express gratitude and strengthen their bonds through meaningful interactions and shared experiences.

How is Father’s Day celebrated?

People celebrate Father’s Day in different ways, depending on family traditions and personal preferences. Common celebrations include:

  • Spending quality time with family
  • Organising a special meal or outing
  • Giving greeting cards and gifts
  • Sharing heartfelt messages and memories
  • Planning activities based on a father’s hobbies and interests

Many families are increasingly choosing experiences such as dining outings, creative workshops and family gatherings over traditional gifts.

Budget-friendly Father’s Day gift ideas

You do not need to spend a large amount of money to make Father’s Day special. Some thoughtful and affordable gift options include:

  • A handwritten letter expressing gratitude
  • A personalised photo frame or photo collage
  • A notebook, planner or quality pen
  • A customised coffee mug
  • A favourite book
  • Homemade snacks or a special meal
  • A keychain with a personal message
  • A DIY greeting card
  • A playlist featuring your father’s favourite songs
  • A family memory scrapbook

Personalised and heartfelt gifts often carry more emotional value than expensive presents and can become cherished keepsakes.

Father’s Day 2026, which falls on June 21, is an occasion to celebrate the love, sacrifices and guidance provided by fathers and father figures. Whether through a thoughtful gift, a heartfelt message or simply spending time together, the day offers a meaningful opportunity to show appreciation and create lasting memories.

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Festivals

Eid 2026 in India may fall on March 20 or 21, moon sighting on March 19 to decide

Eid al-Fitr 2026 in India is expected on March 20 or 21, depending on the crescent moon sighting on March 19.

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Eid al-Fitr 2026 in India is expected to be celebrated on either March 20 or March 21, depending on the sighting of the crescent moon on the evening of March 19.

The festival, which marks the end of the holy month of Ramadan, is observed based on the Islamic lunar calendar. Religious authorities and moon sighting committees across the country will confirm the date only after verifying the visibility of the Shawwal moon.

Eid 2026 date in India

As per astronomical predictions and traditional practices, if the crescent moon is sighted on March 19, Eid will be observed the next day on March 20. However, if the moon is not visible, Ramadan will complete 30 days, and Eid will be celebrated on March 21.

The final announcement is typically made later in the evening after confirmations from different regions.

Chand Raat 2026 timing

“Chand Raat,” the night marking the sighting of the moon, is expected to be observed on Thursday evening, March 19, 2026. It begins shortly after sunset when people look for the crescent moon.

This night holds cultural importance, with markets witnessing increased activity as people prepare for Eid celebrations.

Significance of Eid al-Fitr

Eid al-Fitr signifies the conclusion of Ramadan, a month dedicated to fasting, prayer, and charity. The festival represents gratitude, spiritual renewal, and a sense of unity within the community.

How Eid is celebrated

The day begins with a special congregational prayer held at mosques and open grounds. People dress in new clothes, exchange greetings of “Eid Mubarak,” and visit friends and family.

Traditional dishes, especially seviyan, are prepared and shared. Giving Zakat al-Fitr, a form of charity, is considered essential to ensure that everyone can participate in the celebrations. Chand Raat is also marked by shopping, applying henna, and festive preparations.

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