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New strategy proposed to make breast cancer therapy effective

Published

7 years ago

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[vc_row][vc_column][vc_column_text]Dr. Shikha T. Malik

Scientists have identified mechanisms that make breast cancer stem cells resistant to chemotherapy says a study published in the Scientific Reports journal

New Delhi: A group of Indian scientists have proposed a new strategy to make chemotherapy for triple negative breast cancer more effective.

Scientists at the University of Calcutta and the Saroj Gupta Cancer Care and Research Institute (SGCC&RI), Kolkata, have identified mechanisms that make breast cancer stem cells resistant to chemotherapy. This knowledge, they say, can be used to develop combination therapy along with conventional drugs to tackle aggressive triple negative breast cancer (TNBC). The study results have been published in journal Scientific Reports.

Breast cancer threatens one in every 28 urban women in India. TNBC is a subset of breast cancer which is resistant to most drugs and tends to recur once drug therapy is stopped. It is also aggressive and spreads easily. TNBC patients are generally given intense cycles of chemotherapy in addition to radiation. Clinical studies have shown that TNBC evolves prominently, especially in patients from West Bengal and Bangladesh.

Breast cancer stem cells are resistant to drugs, live longer and proliferate once chemotherapy ends. “This is because elevated expression of drug efflux pumps that throw out the drug from cells,” explained Pritha Mukherjee, a member of the research team.

In this process, the study has found that three molecules – SOX2, ABCG2, and TWIST1 – play an important role. The researchers have further showed that on shutting down SOX2 (which further affects TWIST1 also) and treatment with anti-cancer drug, paclitaxel, restricted migration of cancer stem cells. Even after removal of the drug, these cells did not migrate. “This means obliterating SOX2 expression specifically in breast cancer stem cells before or during chemotherapy is a possible approach to eliminate their population within a tumour, with a promise to prevent post-chemotherapy recurrences,” said Prof Urmi Chatterji of University of Calcutta.

The outcome of this basic understanding may be translated into a clinical method for controlling tumor recurrence. “A treatment strategy which ensures eradication of persistent drug resistant cells would serve as a complete therapy,” Dr Arnab Gupta, Director, SGCC&RI, told India Science Wire.

“Designing new methods which would target SOX2 would in effect render resistant cell population sensitive to anti-cancer drugs,” suggested Prof Dhrubajyoti Chattopadhyay, Vice Chancellor, Amity University, a co-author of the study.

“Further research in our lab by Dr Sreemanti Das has identified nanoformulation of anti-cancer drugs which have the potential to reduce SOX2 expression and effectively obliterate the cancer stem cell population in cells-in-culture as well as in tumors induced in mice. It has immense potential in being developed as a promising drug in future,” added Prof Chatterji. However, detailed clinical studies are needed to translate this research into treatment.

The research team included Dr Urmi Chatterji, Pritha Mukherjee, Dr Arnab Gupta, and Dr Dhrubajyoti Chattopadhyay. The study was funded by Department of Biotechnology.

(This article is from a syndicated feed provided by the India Science Wire)[/vc_column_text][/vc_column][/vc_row]

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Gadgets

WhatsApp to introduce Native File Sharing feature similar to Apple’s AirDrop

Users can choose to be visible to others without disclosing their phone numbers to people who are not their contacts.

Published

10 months ago

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January 24, 2024

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A Meta-owned messaging platform, WhatsApp is all set to introduce a new feature that allows Android users to share files with another user nearby. According to reports, the feature will be developed similar to Apple’s AirDrop.

The file sharing feature nearby is not currently available for beta testers. However, according to a report from WhatsApp feature tracker WABetaInfo, it seems that the feature will soon be introduced. The report reveals a screenshot that shows an option within the app stating, to share files with people nearby, along with a list of nearby users.

It is interesting to note that users can choose to be visible to others without disclosing their phone numbers to people who are not their contacts. In order to share files with other users, one needs to wait for nearby users to accept their request. The process involves a unique interaction, where nearby users can shake their device to receive incoming share requests. It is important to note that this feature is designed with end-to-end encryption to ensure user privacy.

In the upcoming update, WhatsApp is expected to introduce a nearby file-sharing feature. However, the current beta version for Android, which is 2.24.2.20, has addressed a camera issue. Some Android beta testers have reported difficulties in launching the camera within the app after the 2.24.2.13 update. Upon launching, users were presented with an error message that said, can’t start camera, please restart your device. This issue persisted even after restarting the device or relaunching the app.

The latest beta update of WhatsApp, located at 2.24.2.20, has fixed the camera bug. This allows users to launch the camera within the app and share photos and videos with their contacts without any interruptions. As WhatsApp continues its efforts to improve its features and address bugs, users can expect a better messaging experience on the platform.

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Gadgets

Meesho mega blockbuster sale: E-commerce platform to offer 80 percent discount on electronics

The e-commerce platform’s first mega blockbuster sale will sell more than 400 brands directly with the help of authorised partners on its digital store called Meesho Mall.

Published

1 year ago

on

October 6, 2023

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Meesho online shopping app

Ahead of the festive season, e-commerce platform Meesho’s mega blockbuster sale is starting on Friday, October 6, 2023. The platform will provide a massive discount of up to 80 percent on different categories such as essentials, accessories, electronics, footwear, etc.

The blockbuster sale is scheduled to conclude on October 13, 2023. Notably, the Softbank backed e-commerce platform is starting its festive sale a day before Flipkart or Amazon’s festive sale goes live.  The e-commerce platform’s first mega blockbuster sale will sell more than 400 brands directly with the help of authorised partners on its digital store called Meesho Mall.

Reportedly, the platform also added over 50 lakh new customers during these sales. More than 75 percent of the demand was received from Tier-II cities, including Amravati, Aurangabad, Dehradun, Nellore, Solapur, and Warangal. The platform further claimed that they have added more than 2 lakh sellers in the past two years.

Recently, Meesho affirmed that  they have received over 10 million (approx) from its pre-festive sales during Onam, Raksha Bandhan, and Ganesh Chaturthi. The platform has more than 14 lakh sellers, selling approx 12 crore products in 30 different categories. 

In an effort to increase the seller base, the company announced the onboarding of non-GST sellers on the platform earlier this week. The GST council announced to permit the e-commerce platform to onboard sellers with turnover of up to Rs 40 lakh.

Prior to Meesho’s Mega Blockbuster Sale, the company introduced a loyalty programme during which eligible users will earn Smart Coins, which the user can redeem every time they make the purchase of any products on the platform. 

As per Redseer, over 140 million shoppers are likely to make purchases during the festive season. This will enhance the Gross Merchandise Value (GMV) of the Indian e-commerce sector by 18 to 20 per cent and may touch Rs 90,000 crore as compared to Rs 76,000 crore last year.

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Phones & gadgets

Apple launches iPhone 15 series, India price, features, availability  

The iPhone 15 series will be available in India from September 22 but iPhone lovers can also pre-order, starting from September 15 onwards.

Published

1 year ago

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September 13, 2023

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Apple launched its most anticipated iPhone 15 series, including the iPhone 15, iPhone 15 Plus, iPhone 15 Pro and iPhone 15 Pro Max during the Wonderlust event globally on September 12 night.

The iPhone 15 series will be available in India from September 22 but iPhone lovers can also pre-order, starting from September 15 onwards.

People can buy a new iPhone 15 or upgrade it to the old one. There are five colours available for the people.  

According to reports, Apple has been manufacturing the iPhone 15 series in India and China. Apple has moved 7% of its iPhone production to India. Previously, India was not making the newest models. The Centre’s production-linked incentive (PLI) scheme for smartphones played a part in Apple moving its production to India.

The new iPhone 15 has been launched with the same starting price as its prototype, the iPhone 14. The 128GB variant is priced at Rs 79,900, while the 256GB variant costs Rs 89,900. For people who need more storage, the 512GB variant is available for Rs 1,09,900.

This latest iPhone series puffs a 6.1-inch display and comes in five different colours which are pink, yellow, green, blue, and black. While the design remains the same as the previous models, the iPhone 15 features a dynamic island notch instead of the usual notch, which was highly popular among the iPhone 14 Pro phones.

The camera part of the iPhone series has undergone significant upgrades, the new iPhone 15, with an enhanced 48-megapixel primary sensor replaces the 12-megapixel dual camera system which was available in the previous iPhone 14. This significant improvement promises better low-light photography and portrait shots.

The tech giant announced that the iPhone 15 has an all-day battery life, making it more convenient for users to go about their daily activities without worrying about their phone’s battery.

The iPhone 15 Pro models feature a lighter body and thinner bezels. The new AirPods Pro with USB-C charging case will support Lossless Audio with Apple Vision Pro.

Additionally, the iPhone 15 is powered by Apple’s A16 bionic processor, an upgrade from the A15 bionic chipset used in the previous iPhone 14 and iPhone 14 Plus models. The Pro models had the faster and better A16 chip, but now this feature is available in all iPhone 15 models.

The USB-C port on the standard iPhone 15 and iPhone 15 Plus remain limited to lightning speeds up to 480 Mbps. The iPhone 15 Pro and iPhone 15 Pro Max support USB 3 speeds up to 10 Gbps. People will need to buy a separate 1-meter Thunderbolt 4 Pro cable for Rs 5,724 or Rs 10,701 for the 1.8-meter cable to support faster speeds.

The dynamic island notch feature, which can adjust its size according to notifications, was widely discussed before the launch of the iPhone 15. This unique feature can now be available in all models of the phone.

Another important feature of the iPhone 15 is the shift to the USB Type C charging port. Apple has abandoned the lightning port in favour of the more commonly used USB Type C charging port. This means, there is no longer a need for a special iPhone charging cable to be carried around everywhere you go.

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