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New strategy proposed to make breast cancer therapy effective

Published

8 years ago

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[vc_row][vc_column][vc_column_text]Dr. Shikha T. Malik

Scientists have identified mechanisms that make breast cancer stem cells resistant to chemotherapy says a study published in the Scientific Reports journal

New Delhi: A group of Indian scientists have proposed a new strategy to make chemotherapy for triple negative breast cancer more effective.

Scientists at the University of Calcutta and the Saroj Gupta Cancer Care and Research Institute (SGCC&RI), Kolkata, have identified mechanisms that make breast cancer stem cells resistant to chemotherapy. This knowledge, they say, can be used to develop combination therapy along with conventional drugs to tackle aggressive triple negative breast cancer (TNBC). The study results have been published in journal Scientific Reports.

Breast cancer threatens one in every 28 urban women in India. TNBC is a subset of breast cancer which is resistant to most drugs and tends to recur once drug therapy is stopped. It is also aggressive and spreads easily. TNBC patients are generally given intense cycles of chemotherapy in addition to radiation. Clinical studies have shown that TNBC evolves prominently, especially in patients from West Bengal and Bangladesh.

Breast cancer stem cells are resistant to drugs, live longer and proliferate once chemotherapy ends. “This is because elevated expression of drug efflux pumps that throw out the drug from cells,” explained Pritha Mukherjee, a member of the research team.

In this process, the study has found that three molecules – SOX2, ABCG2, and TWIST1 – play an important role. The researchers have further showed that on shutting down SOX2 (which further affects TWIST1 also) and treatment with anti-cancer drug, paclitaxel, restricted migration of cancer stem cells. Even after removal of the drug, these cells did not migrate. “This means obliterating SOX2 expression specifically in breast cancer stem cells before or during chemotherapy is a possible approach to eliminate their population within a tumour, with a promise to prevent post-chemotherapy recurrences,” said Prof Urmi Chatterji of University of Calcutta.

The outcome of this basic understanding may be translated into a clinical method for controlling tumor recurrence. “A treatment strategy which ensures eradication of persistent drug resistant cells would serve as a complete therapy,” Dr Arnab Gupta, Director, SGCC&RI, told India Science Wire.

“Designing new methods which would target SOX2 would in effect render resistant cell population sensitive to anti-cancer drugs,” suggested Prof Dhrubajyoti Chattopadhyay, Vice Chancellor, Amity University, a co-author of the study.

“Further research in our lab by Dr Sreemanti Das has identified nanoformulation of anti-cancer drugs which have the potential to reduce SOX2 expression and effectively obliterate the cancer stem cell population in cells-in-culture as well as in tumors induced in mice. It has immense potential in being developed as a promising drug in future,” added Prof Chatterji. However, detailed clinical studies are needed to translate this research into treatment.

The research team included Dr Urmi Chatterji, Pritha Mukherjee, Dr Arnab Gupta, and Dr Dhrubajyoti Chattopadhyay. The study was funded by Department of Biotechnology.

(This article is from a syndicated feed provided by the India Science Wire)[/vc_column_text][/vc_column][/vc_row]

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Oppo Reno 15 likely to launch in India soon with upgraded camera and performance features

Oppo is preparing to launch the Reno 15 series in India, focusing on camera improvements, performance stability and a refined design. Here’s what to expect from its pricing and features.

Published

6 days ago

on

December 8, 2025

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Oppo is gearing up to introduce its Reno 15 lineup in India, with the series expected to focus heavily on enhanced imaging, performance stability and creator-friendly tools. The smartphone, which has already been launched in China, is anticipated to reach the Indian market in the coming weeks although the company has not yet shared an official date.

Expected price range in India

Industry estimates suggest the standard Oppo Reno 15 will fall in the upper-mid price bracket. While the Reno 15 Pro was launched in China at CNY 3,699 (roughly Rs 46,000), the Reno 15 base model is expected to be more affordable, likely between Rs 32,000 and Rs 38,000, depending on RAM and storage configurations.

Expected features and specifications

The Reno 15 series is expected to highlight Oppo’s improvements in sustained performance, camera capabilities and thermal management. Globally, the models run on ColorOS 16 and feature advanced cooling, particularly aimed at gaming and continuous live-streaming use.

For India, the upcoming Oppo Reno 15 is likely to offer:

  • A high-refresh-rate AMOLED display
  • Triple-camera setup with a primary sensor optimized for better low-light clarity
  • Secondary wide-angle and portrait cameras
  • Front camera with autofocus and AI-led enhancements for live streaming
  • Around 5,000mAh battery with fast wired charging support
  • AI-driven system optimization for smoother long-term performance

Design-wise, it is expected to follow the Reno 15 Pro’s flat-frame style, offering a slim profile, improved durability and brighter display output. With growing demand for creator-focused smartphones in the country, the Reno 15 is being positioned for users interested in mobile photography, vlogging and gaming.

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Samsung Galaxy S25 FE India price leak suggests launch similar to S24 FE

Samsung Galaxy S25 FE India price has surfaced online, hinting at a similar launch price as the S24 FE. The phone brings a 6.7-inch AMOLED display, Exynos 2400 chip, triple rear cameras, and a 4,900mAh battery.

Published

3 months ago

on

September 11, 2025

By

Samsung Galaxy S25 FE, which was unveiled globally on September 4, is yet to receive official pricing for the Indian market. However, a fresh leak indicates that the handset could debut in India at the same price point as its predecessor, the Galaxy S24 FE.

Expected price and availability in India

According to tipster Yogesh Brar, the Samsung Galaxy S25 FE may be priced at ₹59,999 for the base 8GB RAM + 128GB storage variant in India. This matches the launch price of last year’s Galaxy S24 FE, which started at ₹59,999 for the same configuration. The higher 8GB RAM + 256GB model of the S24 FE was earlier priced at ₹65,999.

Globally, the Galaxy S25 FE has been introduced at $650 (around ₹58,000) for the base variant and $710 (around ₹63,000) for the 8GB + 256GB version. In India, the smartphone is expected to go on sale in October, similar to last year’s rollout schedule for the S24 FE.

The phone is offered in Icyblue, Jetblack, Navy, and White colour options.

Key specifications

  • Display: 6.7-inch full-HD+ Dynamic AMOLED 2X, 120Hz refresh rate, 1,900 nits peak brightness, Vision Booster, Gorilla Glass Victus+ protection.
  • Processor: Exynos 2400 SoC.
  • RAM & Storage: 8GB RAM standard, up to 512GB UFS 4.0 storage.
  • Rear Cameras: 50MP wide-angle + 8MP telephoto + 12MP ultrawide; 8K video recording at 30fps.
  • Front Camera: 12MP selfie shooter.
  • Battery: 4,900mAh with 45W wired and 15W wireless charging.
  • Build: 7.4mm thick, 190g weight, IP68-rated water and dust resistance.
  • Cooling: 10% larger vapour chamber compared to the Galaxy S24 FE.

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iPhone 17 series launched in India: Price starts at Rs 82,900, goes up to Rs 2.29 lakh

Apple has launched the iPhone 17 series in India with prices starting at Rs 82,900. Pre-booking begins on 12 September, and the phones will be available from 19 September.

Published

3 months ago

on

September 10, 2025

By

iphone 17

Apple has officially launched its much-awaited iPhone 17 series in India, introducing four models – iPhone 17, iPhone 17 Air, iPhone 17 Pro and iPhone 17 Pro Max. The series comes with advanced features, multiple storage variants, and a starting price of Rs 82,900. Pre-bookings will open from 12 September, while sales begin on 19 September.

iPhone 17 and iPhone 17 Air price in India

The standard iPhone 17 is priced at Rs 82,900 for the 256GB base variant. Meanwhile, the iPhone 17 Air, designed with a slimmer and more premium look, starts at Rs 1,19,900.

Key features of iPhone 17

  • Display: 6.3-inch Super Retina XDR OLED, 120Hz ProMotion, up to 3000 nits brightness with Ceramic Shield 2 protection.
  • Camera: Dual 48MP setup (Fusion main + Ultra Wide) with 2X telephoto capability, along with a new Centre Stage front camera.
  • Performance: Powered by the A19 chipset, runs on iOS 26, 40% faster than iPhone 16.
  • Battery: Up to 8 hours longer backup compared to its predecessor.

iPhone 17 Pro and Pro Max price in India

The premium segment begins with iPhone 17 Pro priced at Rs 1,34,900, while the iPhone 17 Pro Max starts at Rs 1,49,900. The top-end Pro Max with the highest storage option goes up to Rs 2,29,900. These models are available in Cosmic Orange, Deep Blue, and Silver colours.

Key features of Pro models

  • Display: iPhone 17 Pro with 6.3-inch and Pro Max with 6.9-inch Super Retina XDR OLED, both featuring 120Hz refresh rate and 3000 nits brightness.
  • Chipset: New A19 Pro with Vapour Chamber Cooling for heavy usage.
  • Camera: Triple 48MP system including an advanced telephoto lens with 8X optical zoom and 40X digital zoom, plus an 18MP front camera.
  • Battery & Charging: Best-ever battery backup on Pro Max, with USB-C fast charging – 50% charge in just 20 minutes.

Why the iPhone 17 series stands out

The new iPhones not only bring improved design and performance but also integrate Apple Intelligence AI features for messaging, calls and visual tools.

Offers and EMI options

  • No-cost EMI: Available for up to 6 months.
  • Cashback: ICICI Bank users can avail up to Rs 5,000 instant cashback.
  • For instance, buying the iPhone 17 Pro Max (Rs 1,49,900) on a 6-month no-cost EMI plan brings effective savings of Rs 11,525, including cashback and EMI benefits.

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