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In caste-ridden India, genetic isolation may be harmful to health

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8 years ago

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[vc_row][vc_column][vc_column_text]~By Dinesh C Sharma

The occurrence of genetic diseases in certain subpopulations in India and other countries in South Asia is well known. Indian scientists now suspect that this could be due to genetic isolation caused by endogamous marriages over generations.

Endogamous marriages – meaning people marrying within a subpopulation based on caste, gotra, language or culture – lead to reduced genetic variation. They are different from marriages among close relatives (consanguineous marriages) – which is also prevalent in parts of South India.   

In genetics, the phenomenon of a small number of ancestors giving rise to many descendants is known as ‘founder event’ or a population bottleneck. A study of anthropologically different subpopulations in South Asia has revealed that many of them are a result of strong ‘founder events’. In each of such groups, large stretches of DNA originates from a common founder in the last about 100 generations.

There is less genetic variation because these subpopulations have lived in genetic isolation despite co-living with other groups for centuries due to various factors including caste. Such populations are vulnerable to recessive genetic diseases (in which an offspring gets disease-causing genes from both parents). This risk, researchers say, is very different from that due to marriages among close relatives.

The study, led by scientists at Hyderabad-based Centre for Cellular and Molecular Biology (CCMB), appeared in scientific journal Nature Genetics on Tuesday. Scientists analysed samples from over 2800 individuals from over 275 distinct South Asian populations belonging to various social and linguistic groups from India, Pakistan, Nepal, Sri Lanka, and Bangladesh. They developed an algorithm to quantify impact of ‘founder events’ in each group based on stretches in DNA shared from a common founder over generations.

“We found that 81 out of 263 unique South Asian groups, including 14 groups with estimated census sizes of over a million, have a strong founder event,” said Dr Kumarasamy Thangaraj, who led the study along with David Reich of Harvard Medical School.  These large population groups with founder events include Gujjar (Jammu & Kashmir), Baniyas (UP), Pattapu kapu (AP), Vadde (AP), Yadav (Puducherry), Kashtriya Aqnikula (AP), Naga (Nagaland), Kumhar (UP), Reddy (Telangana), Kallar (TN), Brahmin Manipuri (Manipur), Arunthathiyar (TN) and Vysya (Telangana).

Researchers have highlighted the problem through example of Vysya population which has size of more than 3 million. The Vysyas have about 100-fold higher rate of a metabolic disorder called Butyrylcholinesterase (BChE) deficiency compared to other groups. Such people are highly sensitive to anesthesia administered prior to surgery.

“The next step would be to identify specific recessive diseases among various subpopulations and identify genes responsible for them,” Dr Thangaraj told India Science Wire. The research can have significant public health applications, as has been done with some population groups like Ashkenazi Jews, Finns, Amish, Hutterites, Sardinians, and French Canadians in the West. Once recessive genetic diseases specific to different groups are mapped, preventive steps like prenatal testing, premarital counseling and screening can help decrease burden of such diseases in communities.

The team of researchers came from Columbia University; Broad Institute of Harvard and Massachusetts Institute of Technology; Manipal University; Centre for Human Genetics, Bangalore; Mangalore University; Fetal Care Research Foundation, Chennai; Amity University, Noida; Genome Foundation, Hyderabad; Anthropological Survey of India, Kolkata; and Birbal Sahani Institute of Paleosciences, Lucknow. The research was funded by Department of Science and Technology (DST), Department of Biotechnology (DBT), Indian Council of Medical Research (ICMR). (India Science Wire)[/vc_column_text][/vc_column][/vc_row]

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Oppo Reno 15 likely to launch in India soon with upgraded camera and performance features

Oppo is preparing to launch the Reno 15 series in India, focusing on camera improvements, performance stability and a refined design. Here’s what to expect from its pricing and features.

Published

1 month ago

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December 8, 2025

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Oppo is gearing up to introduce its Reno 15 lineup in India, with the series expected to focus heavily on enhanced imaging, performance stability and creator-friendly tools. The smartphone, which has already been launched in China, is anticipated to reach the Indian market in the coming weeks although the company has not yet shared an official date.

Expected price range in India

Industry estimates suggest the standard Oppo Reno 15 will fall in the upper-mid price bracket. While the Reno 15 Pro was launched in China at CNY 3,699 (roughly Rs 46,000), the Reno 15 base model is expected to be more affordable, likely between Rs 32,000 and Rs 38,000, depending on RAM and storage configurations.

Expected features and specifications

The Reno 15 series is expected to highlight Oppo’s improvements in sustained performance, camera capabilities and thermal management. Globally, the models run on ColorOS 16 and feature advanced cooling, particularly aimed at gaming and continuous live-streaming use.

For India, the upcoming Oppo Reno 15 is likely to offer:

  • A high-refresh-rate AMOLED display
  • Triple-camera setup with a primary sensor optimized for better low-light clarity
  • Secondary wide-angle and portrait cameras
  • Front camera with autofocus and AI-led enhancements for live streaming
  • Around 5,000mAh battery with fast wired charging support
  • AI-driven system optimization for smoother long-term performance

Design-wise, it is expected to follow the Reno 15 Pro’s flat-frame style, offering a slim profile, improved durability and brighter display output. With growing demand for creator-focused smartphones in the country, the Reno 15 is being positioned for users interested in mobile photography, vlogging and gaming.

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Samsung Galaxy S25 FE India price leak suggests launch similar to S24 FE

Samsung Galaxy S25 FE India price has surfaced online, hinting at a similar launch price as the S24 FE. The phone brings a 6.7-inch AMOLED display, Exynos 2400 chip, triple rear cameras, and a 4,900mAh battery.

Published

4 months ago

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September 11, 2025

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Samsung Galaxy S25 FE, which was unveiled globally on September 4, is yet to receive official pricing for the Indian market. However, a fresh leak indicates that the handset could debut in India at the same price point as its predecessor, the Galaxy S24 FE.

Expected price and availability in India

According to tipster Yogesh Brar, the Samsung Galaxy S25 FE may be priced at ₹59,999 for the base 8GB RAM + 128GB storage variant in India. This matches the launch price of last year’s Galaxy S24 FE, which started at ₹59,999 for the same configuration. The higher 8GB RAM + 256GB model of the S24 FE was earlier priced at ₹65,999.

Globally, the Galaxy S25 FE has been introduced at $650 (around ₹58,000) for the base variant and $710 (around ₹63,000) for the 8GB + 256GB version. In India, the smartphone is expected to go on sale in October, similar to last year’s rollout schedule for the S24 FE.

The phone is offered in Icyblue, Jetblack, Navy, and White colour options.

Key specifications

  • Display: 6.7-inch full-HD+ Dynamic AMOLED 2X, 120Hz refresh rate, 1,900 nits peak brightness, Vision Booster, Gorilla Glass Victus+ protection.
  • Processor: Exynos 2400 SoC.
  • RAM & Storage: 8GB RAM standard, up to 512GB UFS 4.0 storage.
  • Rear Cameras: 50MP wide-angle + 8MP telephoto + 12MP ultrawide; 8K video recording at 30fps.
  • Front Camera: 12MP selfie shooter.
  • Battery: 4,900mAh with 45W wired and 15W wireless charging.
  • Build: 7.4mm thick, 190g weight, IP68-rated water and dust resistance.
  • Cooling: 10% larger vapour chamber compared to the Galaxy S24 FE.

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iPhone 17 series launched in India: Price starts at Rs 82,900, goes up to Rs 2.29 lakh

Apple has launched the iPhone 17 series in India with prices starting at Rs 82,900. Pre-booking begins on 12 September, and the phones will be available from 19 September.

Published

4 months ago

on

September 10, 2025

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iphone 17

Apple has officially launched its much-awaited iPhone 17 series in India, introducing four models – iPhone 17, iPhone 17 Air, iPhone 17 Pro and iPhone 17 Pro Max. The series comes with advanced features, multiple storage variants, and a starting price of Rs 82,900. Pre-bookings will open from 12 September, while sales begin on 19 September.

iPhone 17 and iPhone 17 Air price in India

The standard iPhone 17 is priced at Rs 82,900 for the 256GB base variant. Meanwhile, the iPhone 17 Air, designed with a slimmer and more premium look, starts at Rs 1,19,900.

Key features of iPhone 17

  • Display: 6.3-inch Super Retina XDR OLED, 120Hz ProMotion, up to 3000 nits brightness with Ceramic Shield 2 protection.
  • Camera: Dual 48MP setup (Fusion main + Ultra Wide) with 2X telephoto capability, along with a new Centre Stage front camera.
  • Performance: Powered by the A19 chipset, runs on iOS 26, 40% faster than iPhone 16.
  • Battery: Up to 8 hours longer backup compared to its predecessor.

iPhone 17 Pro and Pro Max price in India

The premium segment begins with iPhone 17 Pro priced at Rs 1,34,900, while the iPhone 17 Pro Max starts at Rs 1,49,900. The top-end Pro Max with the highest storage option goes up to Rs 2,29,900. These models are available in Cosmic Orange, Deep Blue, and Silver colours.

Key features of Pro models

  • Display: iPhone 17 Pro with 6.3-inch and Pro Max with 6.9-inch Super Retina XDR OLED, both featuring 120Hz refresh rate and 3000 nits brightness.
  • Chipset: New A19 Pro with Vapour Chamber Cooling for heavy usage.
  • Camera: Triple 48MP system including an advanced telephoto lens with 8X optical zoom and 40X digital zoom, plus an 18MP front camera.
  • Battery & Charging: Best-ever battery backup on Pro Max, with USB-C fast charging – 50% charge in just 20 minutes.

Why the iPhone 17 series stands out

The new iPhones not only bring improved design and performance but also integrate Apple Intelligence AI features for messaging, calls and visual tools.

Offers and EMI options

  • No-cost EMI: Available for up to 6 months.
  • Cashback: ICICI Bank users can avail up to Rs 5,000 instant cashback.
  • For instance, buying the iPhone 17 Pro Max (Rs 1,49,900) on a 6-month no-cost EMI plan brings effective savings of Rs 11,525, including cashback and EMI benefits.

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