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High doses of Vitamin C and B3 can kill cancer stem cells: study

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Cancer

[vc_row][vc_column][vc_column_text]By Yogesh Sharma

Colorectal cancer is the third leading cause of cancer deaths worldwide. Dietary fibre and lifestyle changes have been recommended as measures for preventing colorectal cancer.

A team of researchers from Stem Cells and Regenerative Medicine Centre at the Yenepoya University, Karnataka has now found that high doses of water-soluble Vitamin C and niacin or Vitamin B3 can kill cancer stem cells.

In a study published in journalCell Biology International, researchers have shown for the first time the opposing effects of the low and high dose of vitamin C and vitamin B3 on colon cancer stem cells isolated from certain colorectal carcinoma cell lines.

Research team lead by Dr Bipasha Bose and DrSudheer Shenoy investigated the effects of high doses and low doses of the two vitamins and found that low doses (dose range 5-25 micromolar) of Vitamin C and B3 lead to high proliferation and aggressiveness of colon cancer stem cells thereby indicating a need to be cautious while prescribing low doses of these vitamins to colon cancer patients.

High doses of Vitamin C

Sitting from left to right: Dr Sudheer Shenoy and Dr Bipasha Bose; Standing from left to right: Mr DebajitChaudhury, Mr Muhammad Nihad and Mr Utsav Sen

However, high doses of the two vitamins (dose range 100 to 1000 micromolar) were successful in killing cancer stem cells. Such high doses of vitamins can only be achieved through intravenous injections in colon cancer patients.

“The next step of our research is to delineate the mechanisms involved in such opposing effects of low versus high concentrations of the two vitamins,” said Dr Bipasha Bose, a member of the research team. “We want to decipher the mechanisms of action of high doses of Niacin and Vitamin C involving PPARγ pathway and oxidative stress induced killing of colon cancer stem cells. We also want to establish the same dose effect of in-vitro studies under in vivo conditions in tumor xenografts models in mice.”

This work is of significance and researchers hope to establish a therapeutic dose of Vitamin C and B3 for colon cancer stem cell therapy. “If the therapeutic dose gets well validated under in vivo animal models, clinical trials can be a possibility in the long run,” added Dr Bose.

Research Team included Dr.Sudheer Shenoy, Dr.Bipasha Bose, UtsavSen, DebajitChaudhury and Muhammad Nihad. (India Science Wire) [/vc_column_text][/vc_column][/vc_row]

Gadgets

OnePlus Freedom Sale 2026 brings discounts on 15, 15R, 13, Nord 5 and tablets

OnePlus Freedom Sale 2026 begins Jan 16 with discounts on phones, tablets, and audio products across online and offline stores.

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OnePlus has announced its Freedom Sale, offering discounts on smartphones, tablets, and audio products across online and offline platforms. The deals include the recently launched OnePlus 15 series, Nord lineup, Buds audio devices, and other gadgets.

When and where to shop

The OnePlus Freedom Sale starts on Jan. 16 and will run both online and offline. Shoppers can purchase smartphones through OnePlus.in, OnePlus Experience Stores, Amazon, as well as offline retailers including Croma, Reliance Digital, Vijay Sales, and others. Tablets are available on Flipkart during the sale period.

Discounts on OnePlus smartphones

  • OnePlus 15: Launched at Rs 72,999, buyers can get an instant Rs 4,000 discount, lowering the effective price to Rs 68,999. Additional benefits include six months of no-cost EMI and a bundled OnePlus Nord Buds 3.
  • OnePlus 13: Originally priced at Rs 69,999, the phone receives an Rs 8,000 price drop, plus a bank discount of Rs 4,000, bringing the price down to Rs 57,999.
  • OnePlus 15R: Listed at Rs 47,999, buyers can avail Rs 3,000 off until Jan 26. After the date, the effective price is Rs 45,999.
  • OnePlus 13R: Launched at Rs 42,999, this device gets up to Rs 6,000 price cut and an additional Rs 1,000 bank discount.

Discounts on OnePlus tablets

  • OnePlus Pad 2: Rs 2,000 instant bank discount reduces the price to Rs 34,999.
  • OnePlus Pad 3: Eligible for a Rs 3,000 instant discount, making the price Rs 44,999. Purchases until Jan 26 include a free Stylo 2 stylus.
  • OnePlus Pad Go 2: Rs 1,000 price drop plus Rs 2,000 bank discount, now Rs 23,999.
  • OnePlus Pad Go: Price reduced to Rs 13,999 after Rs 3,000 cut and Rs 1,000 bank discount.
  • OnePlus Pad Lite: Available for Rs 11,999 after a Rs 2,000 price drop and Rs 2,000 bank discount.

Audio devices on offer

  • OnePlus Buds 4: Rs 700 price cut with Rs 300 bank discount, bringing the effective price to Rs 4,999.
  • OnePlus Buds Pro 3: Now Rs 9,999 after Rs 1,000 price drop and Rs 1,000 bank discount. No-cost EMI options are available for both Buds 4 and Buds Pro 3.

Additional discounts are also applicable to the Nord Buds series — including Nord Buds 3, Nord Buds 3 Pro, and Nord Buds 3R — and neckband devices such as Bullets Wireless Z2 ANC and Bullets Wireless Z3.

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Gadgets

Oppo Reno 15 likely to launch in India soon with upgraded camera and performance features

Oppo is preparing to launch the Reno 15 series in India, focusing on camera improvements, performance stability and a refined design. Here’s what to expect from its pricing and features.

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Oppo is gearing up to introduce its Reno 15 lineup in India, with the series expected to focus heavily on enhanced imaging, performance stability and creator-friendly tools. The smartphone, which has already been launched in China, is anticipated to reach the Indian market in the coming weeks although the company has not yet shared an official date.

Expected price range in India

Industry estimates suggest the standard Oppo Reno 15 will fall in the upper-mid price bracket. While the Reno 15 Pro was launched in China at CNY 3,699 (roughly Rs 46,000), the Reno 15 base model is expected to be more affordable, likely between Rs 32,000 and Rs 38,000, depending on RAM and storage configurations.

Expected features and specifications

The Reno 15 series is expected to highlight Oppo’s improvements in sustained performance, camera capabilities and thermal management. Globally, the models run on ColorOS 16 and feature advanced cooling, particularly aimed at gaming and continuous live-streaming use.

For India, the upcoming Oppo Reno 15 is likely to offer:

  • A high-refresh-rate AMOLED display
  • Triple-camera setup with a primary sensor optimized for better low-light clarity
  • Secondary wide-angle and portrait cameras
  • Front camera with autofocus and AI-led enhancements for live streaming
  • Around 5,000mAh battery with fast wired charging support
  • AI-driven system optimization for smoother long-term performance

Design-wise, it is expected to follow the Reno 15 Pro’s flat-frame style, offering a slim profile, improved durability and brighter display output. With growing demand for creator-focused smartphones in the country, the Reno 15 is being positioned for users interested in mobile photography, vlogging and gaming.

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Gadgets

Samsung Galaxy S25 FE India price leak suggests launch similar to S24 FE

Samsung Galaxy S25 FE India price has surfaced online, hinting at a similar launch price as the S24 FE. The phone brings a 6.7-inch AMOLED display, Exynos 2400 chip, triple rear cameras, and a 4,900mAh battery.

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Samsung Galaxy S25 FE, which was unveiled globally on September 4, is yet to receive official pricing for the Indian market. However, a fresh leak indicates that the handset could debut in India at the same price point as its predecessor, the Galaxy S24 FE.

Expected price and availability in India

According to tipster Yogesh Brar, the Samsung Galaxy S25 FE may be priced at ₹59,999 for the base 8GB RAM + 128GB storage variant in India. This matches the launch price of last year’s Galaxy S24 FE, which started at ₹59,999 for the same configuration. The higher 8GB RAM + 256GB model of the S24 FE was earlier priced at ₹65,999.

Globally, the Galaxy S25 FE has been introduced at $650 (around ₹58,000) for the base variant and $710 (around ₹63,000) for the 8GB + 256GB version. In India, the smartphone is expected to go on sale in October, similar to last year’s rollout schedule for the S24 FE.

The phone is offered in Icyblue, Jetblack, Navy, and White colour options.

Key specifications

  • Display: 6.7-inch full-HD+ Dynamic AMOLED 2X, 120Hz refresh rate, 1,900 nits peak brightness, Vision Booster, Gorilla Glass Victus+ protection.
  • Processor: Exynos 2400 SoC.
  • RAM & Storage: 8GB RAM standard, up to 512GB UFS 4.0 storage.
  • Rear Cameras: 50MP wide-angle + 8MP telephoto + 12MP ultrawide; 8K video recording at 30fps.
  • Front Camera: 12MP selfie shooter.
  • Battery: 4,900mAh with 45W wired and 15W wireless charging.
  • Build: 7.4mm thick, 190g weight, IP68-rated water and dust resistance.
  • Cooling: 10% larger vapour chamber compared to the Galaxy S24 FE.

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