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High doses of Vitamin C and B3 can kill cancer stem cells: study

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Cancer

[vc_row][vc_column][vc_column_text]By Yogesh Sharma

Colorectal cancer is the third leading cause of cancer deaths worldwide. Dietary fibre and lifestyle changes have been recommended as measures for preventing colorectal cancer.

A team of researchers from Stem Cells and Regenerative Medicine Centre at the Yenepoya University, Karnataka has now found that high doses of water-soluble Vitamin C and niacin or Vitamin B3 can kill cancer stem cells.

In a study published in journalCell Biology International, researchers have shown for the first time the opposing effects of the low and high dose of vitamin C and vitamin B3 on colon cancer stem cells isolated from certain colorectal carcinoma cell lines.

Research team lead by Dr Bipasha Bose and DrSudheer Shenoy investigated the effects of high doses and low doses of the two vitamins and found that low doses (dose range 5-25 micromolar) of Vitamin C and B3 lead to high proliferation and aggressiveness of colon cancer stem cells thereby indicating a need to be cautious while prescribing low doses of these vitamins to colon cancer patients.

High doses of Vitamin C

Sitting from left to right: Dr Sudheer Shenoy and Dr Bipasha Bose; Standing from left to right: Mr DebajitChaudhury, Mr Muhammad Nihad and Mr Utsav Sen

However, high doses of the two vitamins (dose range 100 to 1000 micromolar) were successful in killing cancer stem cells. Such high doses of vitamins can only be achieved through intravenous injections in colon cancer patients.

“The next step of our research is to delineate the mechanisms involved in such opposing effects of low versus high concentrations of the two vitamins,” said Dr Bipasha Bose, a member of the research team. “We want to decipher the mechanisms of action of high doses of Niacin and Vitamin C involving PPARγ pathway and oxidative stress induced killing of colon cancer stem cells. We also want to establish the same dose effect of in-vitro studies under in vivo conditions in tumor xenografts models in mice.”

This work is of significance and researchers hope to establish a therapeutic dose of Vitamin C and B3 for colon cancer stem cell therapy. “If the therapeutic dose gets well validated under in vivo animal models, clinical trials can be a possibility in the long run,” added Dr Bose.

Research Team included Dr.Sudheer Shenoy, Dr.Bipasha Bose, UtsavSen, DebajitChaudhury and Muhammad Nihad. (India Science Wire) [/vc_column_text][/vc_column][/vc_row]

Gadgets

Oppo K14 5G launched in India with 7000mAh battery, starts at Rs 17,999

Oppo has launched the K14 5G in India with a 7000mAh battery, fast charging and durability features, starting at Rs 17,999.

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oppo K14 5G

Oppo has launched its latest mid-range smartphone, the K14 5G, in India, positioning it as an “endurance powerhouse” with a strong focus on battery life, smooth performance and long-term reliability.

The smartphone starts at Rs 17,999 for the 6GB + 128GB variant, while the 6GB + 256GB and 8GB + 256GB models are priced at Rs 19,999 and Rs 21,999 respectively. It will be available for purchase starting March 20 via Flipkart and the company’s official online store. Buyers can also avail an instant discount of up to Rs 1,000 along with no-cost EMI options for up to three months.

Focus on battery life and endurance

A key highlight of the Oppo K14 5G is its 7000mAh battery, designed to support extended daily usage without frequent charging. The company claims the device can deliver up to 738.8 hours of standby time. It also supports long usage across activities such as voice calls, video streaming, navigation and messaging.

The device comes with 45W fast charging, which can charge the battery from 1 percent to 37 percent in around 30 minutes, with a full charge taking about 92 minutes. Oppo says the battery is engineered to maintain durability for up to five years. Reverse wired charging is also supported for added convenience.

Built for durability and everyday use

The smartphone is designed with durability in mind, featuring SGS 5-star certification and MIL-STD-810H military-grade testing. It has undergone multiple drop tests and transportation shock testing to ensure resistance against accidental falls and rough usage conditions.

The device also carries IP66, IP68 and IP69 ratings, offering protection against dust, water immersion and high-pressure water exposure. Additional features like water-repellent camera coating and glove and splash touch support further enhance usability in different environments.

Display and design

The Oppo K14 5G features a 6.75-inch display with a 120Hz refresh rate and brightness of up to 1125 nits in high brightness mode. It is available in three colour options — Icy Blue, Prism Violet and Prism White — with a matte finish and subtle reflective design elements.

Performance and cooling

Powered by the MediaTek Dimensity 6300 chipset, the smartphone is designed to handle everyday tasks such as browsing, streaming and multitasking efficiently. It runs on ColorOS 15, which includes system optimisation features aimed at maintaining smooth performance over time.

To manage heat during extended usage, the device includes a vapor chamber cooling system with graphite layers for improved thermal management. This helps maintain stable performance during gaming and heavy usage.

Camera and AI features

The smartphone is equipped with a 50MP main camera, supported by a 2MP monochrome sensor, along with an 8MP front camera. It offers AI-powered features such as portrait retouching, AI eraser, AI clarity enhancement and dual-view video recording.

These tools are designed to improve image quality, assist in editing and enhance overall photography experience for users.

Availability and after-sales support

The Oppo K14 5G will be available starting March 20 with launch offers including discounts and EMI options. The company is also offering a 30-day inspection and replacement policy in case of manufacturing defects, supported by its nationwide service network.

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Gadgets

OnePlus Freedom Sale 2026 brings discounts on 15, 15R, 13, Nord 5 and tablets

OnePlus Freedom Sale 2026 begins Jan 16 with discounts on phones, tablets, and audio products across online and offline stores.

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OnePlus has announced its Freedom Sale, offering discounts on smartphones, tablets, and audio products across online and offline platforms. The deals include the recently launched OnePlus 15 series, Nord lineup, Buds audio devices, and other gadgets.

When and where to shop

The OnePlus Freedom Sale starts on Jan. 16 and will run both online and offline. Shoppers can purchase smartphones through OnePlus.in, OnePlus Experience Stores, Amazon, as well as offline retailers including Croma, Reliance Digital, Vijay Sales, and others. Tablets are available on Flipkart during the sale period.

Discounts on OnePlus smartphones

  • OnePlus 15: Launched at Rs 72,999, buyers can get an instant Rs 4,000 discount, lowering the effective price to Rs 68,999. Additional benefits include six months of no-cost EMI and a bundled OnePlus Nord Buds 3.
  • OnePlus 13: Originally priced at Rs 69,999, the phone receives an Rs 8,000 price drop, plus a bank discount of Rs 4,000, bringing the price down to Rs 57,999.
  • OnePlus 15R: Listed at Rs 47,999, buyers can avail Rs 3,000 off until Jan 26. After the date, the effective price is Rs 45,999.
  • OnePlus 13R: Launched at Rs 42,999, this device gets up to Rs 6,000 price cut and an additional Rs 1,000 bank discount.

Discounts on OnePlus tablets

  • OnePlus Pad 2: Rs 2,000 instant bank discount reduces the price to Rs 34,999.
  • OnePlus Pad 3: Eligible for a Rs 3,000 instant discount, making the price Rs 44,999. Purchases until Jan 26 include a free Stylo 2 stylus.
  • OnePlus Pad Go 2: Rs 1,000 price drop plus Rs 2,000 bank discount, now Rs 23,999.
  • OnePlus Pad Go: Price reduced to Rs 13,999 after Rs 3,000 cut and Rs 1,000 bank discount.
  • OnePlus Pad Lite: Available for Rs 11,999 after a Rs 2,000 price drop and Rs 2,000 bank discount.

Audio devices on offer

  • OnePlus Buds 4: Rs 700 price cut with Rs 300 bank discount, bringing the effective price to Rs 4,999.
  • OnePlus Buds Pro 3: Now Rs 9,999 after Rs 1,000 price drop and Rs 1,000 bank discount. No-cost EMI options are available for both Buds 4 and Buds Pro 3.

Additional discounts are also applicable to the Nord Buds series — including Nord Buds 3, Nord Buds 3 Pro, and Nord Buds 3R — and neckband devices such as Bullets Wireless Z2 ANC and Bullets Wireless Z3.

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Gadgets

Oppo Reno 15 likely to launch in India soon with upgraded camera and performance features

Oppo is preparing to launch the Reno 15 series in India, focusing on camera improvements, performance stability and a refined design. Here’s what to expect from its pricing and features.

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Oppo is gearing up to introduce its Reno 15 lineup in India, with the series expected to focus heavily on enhanced imaging, performance stability and creator-friendly tools. The smartphone, which has already been launched in China, is anticipated to reach the Indian market in the coming weeks although the company has not yet shared an official date.

Expected price range in India

Industry estimates suggest the standard Oppo Reno 15 will fall in the upper-mid price bracket. While the Reno 15 Pro was launched in China at CNY 3,699 (roughly Rs 46,000), the Reno 15 base model is expected to be more affordable, likely between Rs 32,000 and Rs 38,000, depending on RAM and storage configurations.

Expected features and specifications

The Reno 15 series is expected to highlight Oppo’s improvements in sustained performance, camera capabilities and thermal management. Globally, the models run on ColorOS 16 and feature advanced cooling, particularly aimed at gaming and continuous live-streaming use.

For India, the upcoming Oppo Reno 15 is likely to offer:

  • A high-refresh-rate AMOLED display
  • Triple-camera setup with a primary sensor optimized for better low-light clarity
  • Secondary wide-angle and portrait cameras
  • Front camera with autofocus and AI-led enhancements for live streaming
  • Around 5,000mAh battery with fast wired charging support
  • AI-driven system optimization for smoother long-term performance

Design-wise, it is expected to follow the Reno 15 Pro’s flat-frame style, offering a slim profile, improved durability and brighter display output. With growing demand for creator-focused smartphones in the country, the Reno 15 is being positioned for users interested in mobile photography, vlogging and gaming.

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