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New method developed for faster typhoid diagnosis

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5 years ago

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New method developed for faster typhoid diagnosis

~By Monika Kundu Srivastava

Indian scientists have developed a rapid and accurate method for diagnosis of Salmonella typhi bacteria which causes enteric fever and typhoid.

The new test, developed by scientists at the Indian Institute of Technology (IIT), Delhi, requires minimal blood quantity, besides being accurate and potentially cost-effective. Blood-culture based diagnosis of enteric fever, used at present, is time-consuming and requires skilled practitioners and costly instruments. Besides, these methods sometimes even fail to detect and identify the bacteria correctly.

In blood culture tests for diagnosis of enteric fever, once the bacteria are separated, identification depends on various biochemical and serological tests. Most serological methods, which look for antibodies in the body, are unable to pick up an infection in the early stages as the numbers are low. The lack of specific, rapid and affordable diagnostic tests leads to inappropriate use of antibiotics in all fevers cases.

The new method uses magnetic nanoparticles coupled with antibodies. In tests, it was found that over 65 per cent bacteria cells got bound to nanoparticles within 30 minutes. The bacteria were separated from nanoparticles using magnets by heating it at 65°C for 45 minutes. The cells were reheated at 100°C for 5 minutes to breakdown the covering of bacteria to recover the genetic material. Then the liquid was collected and put through the loop-mediated isothermal amplification (LAMP) process to increase in availability of genetic material required for identification of the bacteria.

This method is quick as there is no need for multiple cycles of rapid heating and cooling as required in traditional methods. The minimum time taken for conventional methods to confirm the presence of disease-causing bacteria is 72 hours while the new method confirmed it in 6 hours, according to results of the study published in journal PLOS One.

The method, according to the study, has the potential for clinical use due to its high detection levels and ability to identify cells which can cause disease in a quicker turnaround time. In future, it can be developed into a handheld and portable device.

The research team included Dinesh Kalyanasundaram, Avinash Kaur and Ravikrishnan Elangovan (IIT, Delhi); Arti Kapil and Sandeep Jha (AIIMS, New Delhi). The study was funded by the Naval Research Board, Department of Science and Technology (DST) and Indo-German Science and Technology. (India Science Wire)

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OnePlus to launch Nord CE 3 in India, specs and price leaked ahead of global debut

OnePlus may soon expand its affordable smartphone series Nord CE. It is being claimed that the company is going to launch the new OnePlus Nord CE 3 in July this year. As per the leaks, the OnePlus Nord CE 3 will be introduced as a successor to the OnePlus Nord CE 2.

Published

3 months ago

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March 3, 2023

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OnePlus smartphone

OnePlus may soon expand its affordable smartphone series Nord CE. It is being claimed that the company is going to launch the new OnePlus Nord CE 3 in July this year. As per the leaks, the OnePlus Nord CE 3 will be introduced as a successor to the OnePlus Nord CE 2. The information about the phone has also been revealed ahead of its official debut on many digital platforms. However, the company has not yet given any information regarding the same as yet.

According to a report by My Smart Price, the OnePlus Nord CE 3 is expected to launch in July alongside of OnePlus Nord 3. The tipster also has claimed about the specification of the phone as well. Scroll down to know more about the smartphone.

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According to tipster Steve Hemmerstoffer (@OnLeaks), the OnePlus CE 3 will come with a display with 120Hz refresh rate, under which the user will be able to have a high definition display quality while playing videos. The handset is also likely to feature a 6.72 inch Full HD Plus AMOLED display. Earlier it was being said that this phone will be introduced with an IPS LCD screen. However, the confirmation is still awaited.

Leaks also suggested that the OnePlus Nord CE 3 is expected to be powered by the octa-core Snapdragon 782G processor coupled with up to 12GB of RAM and up to 256GB of inbuilt storage. The upcoming OnePlus Nord CE 3 could be equipped with three rear cameras. The phone can get a 50-megapixel Sony IMX890 primary sensor, an 8-megapixel ultra-wide-angle lens, and a 2-megapixel macro lens. The phone is expected to get a 16-megapixel sensor for selfie and video calls.

The handset is said to have an in-display fingerprint sensor, a 5000mAh battery with 80W fast charging support, dual-band Wi-Fi, 5G, 4G LTE, Bluetooth and a USB Type-C port.

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Vivo launches color-changing back panel smartphone V27 Pro in India, check price and specs

The Chinese smartphone manufacturer Vivo has launched its awaited color-changing back panel smartphone V27 Pro in India, along with the lower variant V27. Interested customers can purchase the handset in magic blue and noble black color

Published

3 months ago

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March 1, 2023

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Vivo V27 Smartphone

The Chinese smartphone manufacturer Vivo has launched its awaited color-changing back panel smartphone V27 Pro in India, along with the lower variant V27. Interested customers can purchase the handset in magic blue and noble black color. Pre-booking of Vivo V27 Pro has started and sales will be from March 6. The sale of Vivo V27 will start from 23 March.

As per the official details, the handset is the upgraded version of the Vivo V25 series, which was launched last year. The company has introduced the Vivo V27 Series with Android 13-based Funtouch OS 13 and MediaTek processor, under which customers will be able to access heavy applications without and lag.

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Know everything about the Vivo’s Vivo V27 and V27 Pro

As per the photos shared by the company, Vivo V27 Pro and Vivo V27 come with a 3D curved screen with a refresh rate of 120Hz that offers users to have a high-definition screen experience while playing any video. It comes with a glass panel that changes color whenever some light or sun rays strike it. Both Vivo V27 Pro and Vivo V27 phones have three rear cameras, and features. The Vivo V27 Pro has a MediaTek Dimensity 8200 processor, while Vivo V27 has Dimensity 7200 5G processor. Both the chipset have been considered the advance chipset in the Indian market.

Price of Vivo’s V27 and V27 Pro

The price of 128 GB storage with 8 GB RAM of Vivo V27 Pro is Rs 37,999. At the same time, the price of 256 GB storage with 8 GB RAM has been kept at Rs 39,999. The 256 GB storage variant with the phone’s 12 GB RAM is priced at Rs 42,999. The price of 128 GB storage with 8 GB RAM of Vivo V27 has been priced at Rs 32,999 and 256 GB storage with 12 GB RAM has been priced at Rs 36,999.

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Samsung set to launch Galaxy S23 FE, design and specs leaked ahead of official launch

Published

4 months ago

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February 22, 2023

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The leading smartphone manufacturer Samsung recently launched the Galaxy S23 series in India, since then, the handsets became the talk of the time. Now the company is all set to attract more customers as it has decided to launch an affordable variant of Samsung Galaxy S23 FE in the country.

Ahead of the official launch, many information such as specs, design leaked on digital platforms, claiming the handset might come with the latest processor with a 120 Hz AMOLE display that will allow users to have a high-definition experience while playing videos or using the phone. As per the leaks, the phone could be equipped with a flagship chipset launched by Qualcomm last year. However, the South Korean tech giant hasn’t revealed anything regarding the same as of now. Not even the price and launch date.

Once launched, interested customers can purchase the smartphone from the company’s authorized store. If one wants it at an additional discount, they can purchase the phone from the e-commerce giant Amazon or Flipkart.

Know everything about Samsung Galaxy S21 FE

Tipster Connor (@OreXda) claims that the Samsung Galaxy S23 FE will be powered by the Snapdragon 8+ Gen 1 processor. It is the second most powerful chipset from Qualcomm after Snapdragon 8 Gen 2. A lot of flagship phones of this year shared the with same Snapdragon 8 Gen 1 such as OnePlus 11R, Xiaomi 12S Ultra, Asus Zenfone 9, Samsung Galaxy Z Flip 4, and Oppo Find N2 among others.

It said that the upcoming Samsung Galaxy S21 FE might replace the company’s feature-loaded smartphone Galaxy A74. It is expected that the company likely to launch the S21 FE at a similar price as A74.


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