English हिन्दी
Connect with us

Gadgets

New strategy proposed to make breast cancer therapy effective

Published

8 years ago

on

[vc_row][vc_column][vc_column_text]Dr. Shikha T. Malik

Scientists have identified mechanisms that make breast cancer stem cells resistant to chemotherapy says a study published in the Scientific Reports journal

New Delhi: A group of Indian scientists have proposed a new strategy to make chemotherapy for triple negative breast cancer more effective.

Scientists at the University of Calcutta and the Saroj Gupta Cancer Care and Research Institute (SGCC&RI), Kolkata, have identified mechanisms that make breast cancer stem cells resistant to chemotherapy. This knowledge, they say, can be used to develop combination therapy along with conventional drugs to tackle aggressive triple negative breast cancer (TNBC). The study results have been published in journal Scientific Reports.

Breast cancer threatens one in every 28 urban women in India. TNBC is a subset of breast cancer which is resistant to most drugs and tends to recur once drug therapy is stopped. It is also aggressive and spreads easily. TNBC patients are generally given intense cycles of chemotherapy in addition to radiation. Clinical studies have shown that TNBC evolves prominently, especially in patients from West Bengal and Bangladesh.

Breast cancer stem cells are resistant to drugs, live longer and proliferate once chemotherapy ends. “This is because elevated expression of drug efflux pumps that throw out the drug from cells,” explained Pritha Mukherjee, a member of the research team.

In this process, the study has found that three molecules – SOX2, ABCG2, and TWIST1 – play an important role. The researchers have further showed that on shutting down SOX2 (which further affects TWIST1 also) and treatment with anti-cancer drug, paclitaxel, restricted migration of cancer stem cells. Even after removal of the drug, these cells did not migrate. “This means obliterating SOX2 expression specifically in breast cancer stem cells before or during chemotherapy is a possible approach to eliminate their population within a tumour, with a promise to prevent post-chemotherapy recurrences,” said Prof Urmi Chatterji of University of Calcutta.

The outcome of this basic understanding may be translated into a clinical method for controlling tumor recurrence. “A treatment strategy which ensures eradication of persistent drug resistant cells would serve as a complete therapy,” Dr Arnab Gupta, Director, SGCC&RI, told India Science Wire.

“Designing new methods which would target SOX2 would in effect render resistant cell population sensitive to anti-cancer drugs,” suggested Prof Dhrubajyoti Chattopadhyay, Vice Chancellor, Amity University, a co-author of the study.

“Further research in our lab by Dr Sreemanti Das has identified nanoformulation of anti-cancer drugs which have the potential to reduce SOX2 expression and effectively obliterate the cancer stem cell population in cells-in-culture as well as in tumors induced in mice. It has immense potential in being developed as a promising drug in future,” added Prof Chatterji. However, detailed clinical studies are needed to translate this research into treatment.

The research team included Dr Urmi Chatterji, Pritha Mukherjee, Dr Arnab Gupta, and Dr Dhrubajyoti Chattopadhyay. The study was funded by Department of Biotechnology.

(This article is from a syndicated feed provided by the India Science Wire)[/vc_column_text][/vc_column][/vc_row]

Related Topics:
Continue Reading

Gadgets

Samsung Galaxy S25 FE India price leak suggests launch similar to S24 FE

Samsung Galaxy S25 FE India price has surfaced online, hinting at a similar launch price as the S24 FE. The phone brings a 6.7-inch AMOLED display, Exynos 2400 chip, triple rear cameras, and a 4,900mAh battery.

Published

3 months ago

on

September 11, 2025

By

Samsung Galaxy S25 FE, which was unveiled globally on September 4, is yet to receive official pricing for the Indian market. However, a fresh leak indicates that the handset could debut in India at the same price point as its predecessor, the Galaxy S24 FE.

Expected price and availability in India

According to tipster Yogesh Brar, the Samsung Galaxy S25 FE may be priced at ₹59,999 for the base 8GB RAM + 128GB storage variant in India. This matches the launch price of last year’s Galaxy S24 FE, which started at ₹59,999 for the same configuration. The higher 8GB RAM + 256GB model of the S24 FE was earlier priced at ₹65,999.

Globally, the Galaxy S25 FE has been introduced at $650 (around ₹58,000) for the base variant and $710 (around ₹63,000) for the 8GB + 256GB version. In India, the smartphone is expected to go on sale in October, similar to last year’s rollout schedule for the S24 FE.

The phone is offered in Icyblue, Jetblack, Navy, and White colour options.

Key specifications

  • Display: 6.7-inch full-HD+ Dynamic AMOLED 2X, 120Hz refresh rate, 1,900 nits peak brightness, Vision Booster, Gorilla Glass Victus+ protection.
  • Processor: Exynos 2400 SoC.
  • RAM & Storage: 8GB RAM standard, up to 512GB UFS 4.0 storage.
  • Rear Cameras: 50MP wide-angle + 8MP telephoto + 12MP ultrawide; 8K video recording at 30fps.
  • Front Camera: 12MP selfie shooter.
  • Battery: 4,900mAh with 45W wired and 15W wireless charging.
  • Build: 7.4mm thick, 190g weight, IP68-rated water and dust resistance.
  • Cooling: 10% larger vapour chamber compared to the Galaxy S24 FE.

Continue Reading

Gadgets

iPhone 17 series launched in India: Price starts at Rs 82,900, goes up to Rs 2.29 lakh

Apple has launched the iPhone 17 series in India with prices starting at Rs 82,900. Pre-booking begins on 12 September, and the phones will be available from 19 September.

Published

3 months ago

on

September 10, 2025

By

iphone 17

Apple has officially launched its much-awaited iPhone 17 series in India, introducing four models – iPhone 17, iPhone 17 Air, iPhone 17 Pro and iPhone 17 Pro Max. The series comes with advanced features, multiple storage variants, and a starting price of Rs 82,900. Pre-bookings will open from 12 September, while sales begin on 19 September.

iPhone 17 and iPhone 17 Air price in India

The standard iPhone 17 is priced at Rs 82,900 for the 256GB base variant. Meanwhile, the iPhone 17 Air, designed with a slimmer and more premium look, starts at Rs 1,19,900.

Key features of iPhone 17

  • Display: 6.3-inch Super Retina XDR OLED, 120Hz ProMotion, up to 3000 nits brightness with Ceramic Shield 2 protection.
  • Camera: Dual 48MP setup (Fusion main + Ultra Wide) with 2X telephoto capability, along with a new Centre Stage front camera.
  • Performance: Powered by the A19 chipset, runs on iOS 26, 40% faster than iPhone 16.
  • Battery: Up to 8 hours longer backup compared to its predecessor.

iPhone 17 Pro and Pro Max price in India

The premium segment begins with iPhone 17 Pro priced at Rs 1,34,900, while the iPhone 17 Pro Max starts at Rs 1,49,900. The top-end Pro Max with the highest storage option goes up to Rs 2,29,900. These models are available in Cosmic Orange, Deep Blue, and Silver colours.

Key features of Pro models

  • Display: iPhone 17 Pro with 6.3-inch and Pro Max with 6.9-inch Super Retina XDR OLED, both featuring 120Hz refresh rate and 3000 nits brightness.
  • Chipset: New A19 Pro with Vapour Chamber Cooling for heavy usage.
  • Camera: Triple 48MP system including an advanced telephoto lens with 8X optical zoom and 40X digital zoom, plus an 18MP front camera.
  • Battery & Charging: Best-ever battery backup on Pro Max, with USB-C fast charging – 50% charge in just 20 minutes.

Why the iPhone 17 series stands out

The new iPhones not only bring improved design and performance but also integrate Apple Intelligence AI features for messaging, calls and visual tools.

Offers and EMI options

  • No-cost EMI: Available for up to 6 months.
  • Cashback: ICICI Bank users can avail up to Rs 5,000 instant cashback.
  • For instance, buying the iPhone 17 Pro Max (Rs 1,49,900) on a 6-month no-cost EMI plan brings effective savings of Rs 11,525, including cashback and EMI benefits.

Continue Reading

Gadgets

Lava Yuva Smart 2 launched in India with 5,000mAh battery and dual cameras

Lava has launched the Yuva Smart 2 in India with a 5,000mAh battery, dual cameras, Android 15 Go Edition, and a price tag of Rs 6,099.

Published

3 months ago

on

September 4, 2025

By

Lava phone

Lava has introduced its latest entry-level smartphone, the Lava Yuva Smart 2, in India. Priced at Rs 6,099, the device offers a large display, a massive battery, and dual cameras, making it a budget-friendly choice for first-time smartphone buyers.

Lava Yuva Smart 2 price and availability

The Yuva Smart 2 is priced at Rs 6,099 for the single 3GB RAM + 64GB storage variant. It will be available in Crystal Blue and Crystal Gold colour options. Lava has announced doorstep service across India, though official sale dates are yet to be disclosed.

Lava Yuva Smart 2 specifications

The smartphone runs on Android 15 Go Edition and is powered by the Unisoc 9863a octa-core chipset. It comes with 3GB RAM (expandable up to 6GB with virtual RAM) and 64GB internal storage.

It features a 6.75-inch HD+ display with a 90Hz refresh rate. For photography, the phone sports a 13MP AI dual rear camera housed in a square module, along with a 5MP front camera for selfies.

Backed by a 5,000mAh battery with 10W wired charging via USB Type-C, the device also includes a side-mounted fingerprint scanner and face unlock support for security.

Continue Reading

Trending

© Copyright 2022 APNLIVE.com