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Nobel for medicine to researchers for cancer treatment breakthrough

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Nobel for medicine to researchers for cancer treatment breakthrough

James P Allison of the US and Tasuku Honjo of Japan were today (Monday, October 1) awarded the 2018 Nobel Prize in Physiology or Medicine for discovery of a type of cancer treatment that harnesses a person’s own immune system, revolutionising the treatment of cancer .

“By stimulating the inherent ability of our immune system to attack tumor cells this year’s Nobel Laureates have established an entirely new principle for cancer therapy,” the Nobel Prize Foundation said in a statement.

Nobel for medicine to researchers for cancer treatment breakthrough“Allison and Honjo showed how different strategies for inhibiting the brakes on the immune system can be used in the treatment of cancer,” the Nobel Assembly at Sweden’s Karolinska Institute said in a statement on Monday, jointly awarding the prize of 9 million Swedish crowns (€870,000, $1 million) to the two scientists.

Medicine is the first of the Nobel Prizes awarded each year. The prizes for achievements in science, literature and peace were created in accordance with the will of dynamite inventor and businessman Alfred Nobel, and have been awarded since 1901.

The literature prize will not be handed out this year after the awarding body was hit by a sexual misconduct scandal.

The two medicine laureates studied proteins that prevent the body and its main immune cells, known as T-cells, from attacking tumour cells effectively.

Allison, who is a professor at the University of Texas MD Anderson Cancer Center, Houston, was studying a protein called CTLA-4 that inhibits a person’s immune system by putting the brakes on the actions of T cells. He realized that if he could release that “brake”, the immune system would wreak havoc on tumours. Allison developed this idea into a new type of cancer treatment.

Meanwhile, Honjo, who is now a professor at Kyoto University in Japan, discovered a similar immune system-braking protein. Called PD-1, this protein, he found, functions as a T-cell brake but via a different mechanism than CTLA-4 uses. Honjo’s research led to the clinical development of treating cancer patients by targeting that protein.

Whereas both proteins have proven to be effective targets for treating different types of cancer, PD-1 has shown stronger results for the so-called immune checkpoint therapy, according to the Nobel Prize Foundation. Targeting PD-1 has shown positive results in treating lung cancer, renal cancer, lymphoma and melanoma. And more recently, scientists have found that combining the two targets can be even more effective in cancer treatment, particularly in combating melanoma.

Honjo and Allison will split the Nobel prize amount of 9 million in Swedish krona, or $1.01 million.

Gadgets

OnePlus Freedom Sale 2026 brings discounts on 15, 15R, 13, Nord 5 and tablets

OnePlus Freedom Sale 2026 begins Jan 16 with discounts on phones, tablets, and audio products across online and offline stores.

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OnePlus has announced its Freedom Sale, offering discounts on smartphones, tablets, and audio products across online and offline platforms. The deals include the recently launched OnePlus 15 series, Nord lineup, Buds audio devices, and other gadgets.

When and where to shop

The OnePlus Freedom Sale starts on Jan. 16 and will run both online and offline. Shoppers can purchase smartphones through OnePlus.in, OnePlus Experience Stores, Amazon, as well as offline retailers including Croma, Reliance Digital, Vijay Sales, and others. Tablets are available on Flipkart during the sale period.

Discounts on OnePlus smartphones

  • OnePlus 15: Launched at Rs 72,999, buyers can get an instant Rs 4,000 discount, lowering the effective price to Rs 68,999. Additional benefits include six months of no-cost EMI and a bundled OnePlus Nord Buds 3.
  • OnePlus 13: Originally priced at Rs 69,999, the phone receives an Rs 8,000 price drop, plus a bank discount of Rs 4,000, bringing the price down to Rs 57,999.
  • OnePlus 15R: Listed at Rs 47,999, buyers can avail Rs 3,000 off until Jan 26. After the date, the effective price is Rs 45,999.
  • OnePlus 13R: Launched at Rs 42,999, this device gets up to Rs 6,000 price cut and an additional Rs 1,000 bank discount.

Discounts on OnePlus tablets

  • OnePlus Pad 2: Rs 2,000 instant bank discount reduces the price to Rs 34,999.
  • OnePlus Pad 3: Eligible for a Rs 3,000 instant discount, making the price Rs 44,999. Purchases until Jan 26 include a free Stylo 2 stylus.
  • OnePlus Pad Go 2: Rs 1,000 price drop plus Rs 2,000 bank discount, now Rs 23,999.
  • OnePlus Pad Go: Price reduced to Rs 13,999 after Rs 3,000 cut and Rs 1,000 bank discount.
  • OnePlus Pad Lite: Available for Rs 11,999 after a Rs 2,000 price drop and Rs 2,000 bank discount.

Audio devices on offer

  • OnePlus Buds 4: Rs 700 price cut with Rs 300 bank discount, bringing the effective price to Rs 4,999.
  • OnePlus Buds Pro 3: Now Rs 9,999 after Rs 1,000 price drop and Rs 1,000 bank discount. No-cost EMI options are available for both Buds 4 and Buds Pro 3.

Additional discounts are also applicable to the Nord Buds series — including Nord Buds 3, Nord Buds 3 Pro, and Nord Buds 3R — and neckband devices such as Bullets Wireless Z2 ANC and Bullets Wireless Z3.

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Oppo Reno 15 likely to launch in India soon with upgraded camera and performance features

Oppo is preparing to launch the Reno 15 series in India, focusing on camera improvements, performance stability and a refined design. Here’s what to expect from its pricing and features.

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Oppo is gearing up to introduce its Reno 15 lineup in India, with the series expected to focus heavily on enhanced imaging, performance stability and creator-friendly tools. The smartphone, which has already been launched in China, is anticipated to reach the Indian market in the coming weeks although the company has not yet shared an official date.

Expected price range in India

Industry estimates suggest the standard Oppo Reno 15 will fall in the upper-mid price bracket. While the Reno 15 Pro was launched in China at CNY 3,699 (roughly Rs 46,000), the Reno 15 base model is expected to be more affordable, likely between Rs 32,000 and Rs 38,000, depending on RAM and storage configurations.

Expected features and specifications

The Reno 15 series is expected to highlight Oppo’s improvements in sustained performance, camera capabilities and thermal management. Globally, the models run on ColorOS 16 and feature advanced cooling, particularly aimed at gaming and continuous live-streaming use.

For India, the upcoming Oppo Reno 15 is likely to offer:

  • A high-refresh-rate AMOLED display
  • Triple-camera setup with a primary sensor optimized for better low-light clarity
  • Secondary wide-angle and portrait cameras
  • Front camera with autofocus and AI-led enhancements for live streaming
  • Around 5,000mAh battery with fast wired charging support
  • AI-driven system optimization for smoother long-term performance

Design-wise, it is expected to follow the Reno 15 Pro’s flat-frame style, offering a slim profile, improved durability and brighter display output. With growing demand for creator-focused smartphones in the country, the Reno 15 is being positioned for users interested in mobile photography, vlogging and gaming.

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Samsung Galaxy S25 FE India price leak suggests launch similar to S24 FE

Samsung Galaxy S25 FE India price has surfaced online, hinting at a similar launch price as the S24 FE. The phone brings a 6.7-inch AMOLED display, Exynos 2400 chip, triple rear cameras, and a 4,900mAh battery.

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Samsung Galaxy S25 FE, which was unveiled globally on September 4, is yet to receive official pricing for the Indian market. However, a fresh leak indicates that the handset could debut in India at the same price point as its predecessor, the Galaxy S24 FE.

Expected price and availability in India

According to tipster Yogesh Brar, the Samsung Galaxy S25 FE may be priced at ₹59,999 for the base 8GB RAM + 128GB storage variant in India. This matches the launch price of last year’s Galaxy S24 FE, which started at ₹59,999 for the same configuration. The higher 8GB RAM + 256GB model of the S24 FE was earlier priced at ₹65,999.

Globally, the Galaxy S25 FE has been introduced at $650 (around ₹58,000) for the base variant and $710 (around ₹63,000) for the 8GB + 256GB version. In India, the smartphone is expected to go on sale in October, similar to last year’s rollout schedule for the S24 FE.

The phone is offered in Icyblue, Jetblack, Navy, and White colour options.

Key specifications

  • Display: 6.7-inch full-HD+ Dynamic AMOLED 2X, 120Hz refresh rate, 1,900 nits peak brightness, Vision Booster, Gorilla Glass Victus+ protection.
  • Processor: Exynos 2400 SoC.
  • RAM & Storage: 8GB RAM standard, up to 512GB UFS 4.0 storage.
  • Rear Cameras: 50MP wide-angle + 8MP telephoto + 12MP ultrawide; 8K video recording at 30fps.
  • Front Camera: 12MP selfie shooter.
  • Battery: 4,900mAh with 45W wired and 15W wireless charging.
  • Build: 7.4mm thick, 190g weight, IP68-rated water and dust resistance.
  • Cooling: 10% larger vapour chamber compared to the Galaxy S24 FE.

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