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Nobel for medicine to researchers for cancer treatment breakthrough

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Nobel for medicine to researchers for cancer treatment breakthrough

James P Allison of the US and Tasuku Honjo of Japan were today (Monday, October 1) awarded the 2018 Nobel Prize in Physiology or Medicine for discovery of a type of cancer treatment that harnesses a person’s own immune system, revolutionising the treatment of cancer .

“By stimulating the inherent ability of our immune system to attack tumor cells this year’s Nobel Laureates have established an entirely new principle for cancer therapy,” the Nobel Prize Foundation said in a statement.

Nobel for medicine to researchers for cancer treatment breakthrough“Allison and Honjo showed how different strategies for inhibiting the brakes on the immune system can be used in the treatment of cancer,” the Nobel Assembly at Sweden’s Karolinska Institute said in a statement on Monday, jointly awarding the prize of 9 million Swedish crowns (€870,000, $1 million) to the two scientists.

Medicine is the first of the Nobel Prizes awarded each year. The prizes for achievements in science, literature and peace were created in accordance with the will of dynamite inventor and businessman Alfred Nobel, and have been awarded since 1901.

The literature prize will not be handed out this year after the awarding body was hit by a sexual misconduct scandal.

The two medicine laureates studied proteins that prevent the body and its main immune cells, known as T-cells, from attacking tumour cells effectively.

Allison, who is a professor at the University of Texas MD Anderson Cancer Center, Houston, was studying a protein called CTLA-4 that inhibits a person’s immune system by putting the brakes on the actions of T cells. He realized that if he could release that “brake”, the immune system would wreak havoc on tumours. Allison developed this idea into a new type of cancer treatment.

Meanwhile, Honjo, who is now a professor at Kyoto University in Japan, discovered a similar immune system-braking protein. Called PD-1, this protein, he found, functions as a T-cell brake but via a different mechanism than CTLA-4 uses. Honjo’s research led to the clinical development of treating cancer patients by targeting that protein.

Whereas both proteins have proven to be effective targets for treating different types of cancer, PD-1 has shown stronger results for the so-called immune checkpoint therapy, according to the Nobel Prize Foundation. Targeting PD-1 has shown positive results in treating lung cancer, renal cancer, lymphoma and melanoma. And more recently, scientists have found that combining the two targets can be even more effective in cancer treatment, particularly in combating melanoma.

Honjo and Allison will split the Nobel prize amount of 9 million in Swedish krona, or $1.01 million.

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Samsung Galaxy S25 Ultra and iPhone 16 Pro Max: A comparative look at prices and specs in India

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Samsung Galaxy S25 Ultra with car crash detection feature

Samsung has introduced its latest high-end flagship, the Galaxy S25 Ultra, in India, igniting a new chapter in its ongoing rivalry with Apple’s iPhone 16 Pro Max. Both phones represent the pinnacle of smartphone technology, but they come at distinct price points and offer different specifications that cater to various user preferences.

Price comparison in India

The Galaxy S25 Ultra is available in three variants: the base model with 256GB of storage is priced at Rs 1,29,999; the 512GB model at Rs 1,49,999; and the 1TB version at Rs 1,65,999. These variants are offered in four color options: Titanium Silver Blue, Titanium Gray, Titanium White, and Titanium Black.

In contrast, the iPhone 16 Pro Max starts at Rs 1,44,900 for the 256GB model, with the 512GB and 1TB versions priced at Rs 1,64,900 and Rs 1,84,900, respectively. Samsung’s offerings are notably less expensive across similar storage options, with the 1TB model being nearly Rs 19,000 cheaper than its Apple counterpart.

Specifications face-off

The Samsung Galaxy S25 Ultra boasts a 6.9-inch display, slightly larger than its predecessor, and features a more contemporary design with rounded edges. Despite its larger size, it maintains a lightweight feel at only 218 grams and includes a robust 5,000mAh battery. The camera setup has been significantly upgraded, featuring a 200-megapixel primary sensor paired with a 50-megapixel ultra-wide and a 50-megapixel telephoto lens. It is powered by the Snapdragon 8 Elite for Galaxy, enhancing both efficiency and performance.

The iPhone 16 Pro Max, also with a 6.9-inch display, utilizes Apple’s Super Retina XDR technology with Always-On and ProMotion features for a superior viewing experience. It includes a new gold color option and a novel Camera Control button, adding functionality exclusive to the Pro models. The device is equipped with the A18 Pro chipset and features a redesigned camera system with a 48-megapixel primary sensor and advanced video recording capabilities.

Performance and functionality

Both the Galaxy S25 Ultra and the iPhone 16 Pro Max are designed to offer top-tier performance. Samsung’s flagship includes 12GB of RAM, compared to the iPhone’s 8GB, potentially offering a smoother multitasking experience. The iPhone, however, continues to impress with its integration of hardware and software, leading to efficient performance in real-life usage scenarios.

This detailed examination highlights the strengths of each device, allowing consumers to make an informed decision based on their specific needs and preferences. Whether prioritizing camera technology, display features, or price, the Samsung Galaxy S25 Ultra and iPhone 16 Pro Max cater to all facets of premium smartphone requirements.

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Oppo Find N5 set to launch with 50W wireless charging and IPX9 water resistance

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Oppo Find N5 being tested underwater to showcase its IPX9 water resistance rating.

Oppo has officially confirmed that its latest innovation, the Find N5, will support 50W wireless charging and feature an IPX9 water resistance rating. The announcement comes as part of a series of teases highlighting the capabilities of this next-generation foldable smartphone, set to launch in February.

According to recent leaks, the Find N5 will be the first smartphone to incorporate the Qualcomm Snapdragon 8 Elite SoC, signaling significant performance enhancements. Pete Lau, Oppo’s Chief Product Officer, has touted the device as the “thinnest foldable phone,” positioning it against leading competitors like the latest iPhone in terms of sleek design.

Zhou Yibao, head of the Oppo Find series, shared insights via Weibo about the Find N5’s advanced features. The device not only matches the wireless charging speeds of newly released models like the Oppo Find X8 Pro and OnePlus 13 but also integrates seamlessly with in-car systems from major electric vehicle brands such as BYD and NIO.

In a compelling demonstration of its durability, a recent video posted by Yibao showed the Find N5 being submerged underwater, showcasing its capability to withstand significant water exposure, evidenced by its IPX9 rating. This test included recording underwater videos, highlighting the phone’s versatile camera capabilities in extreme conditions.

The Find N5 also sports a refined design with slimmer borders and a larger overall form factor compared to its predecessors, which could attract users looking for a sleek yet robust foldable phone.

As anticipation builds, Oppo has begun sharing images of the Find N5, revealing a foldable design as thin as a USB-C port when opened. This device promises to merge aesthetic appeal with functional excellence, setting a new benchmark in the evolving foldable phone market.

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Realme 14 Pro series set to launch in India tomorrow: Expected specs, price, and more

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Realme 14 Pro series launch with AMOLED display, Snapdragon 7s Gen 3 processor, and advanced camera setup.

Realme is gearing up to unveil its latest mid-range smartphones, the Realme 14 Pro series, in India on January 16, 2025. The much-anticipated event will also mark the launch of Realme Buds 5 wireless earphones, adding to the excitement among tech enthusiasts.

When and where to watch the launch

The Realme 14 Pro series will be launched at 12 noon on Thursday, January 16. Fans can catch the live-streamed event on Realme’s official YouTube channel.

Realme 14 Pro series specifications (Expected)

The Realme 14 Pro series, including the Realme 14 Pro and Realme 14 Pro+, has already been introduced in China, offering a sneak peek into its features.

The Realme 14 Pro boasts a 6.83-inch Full HD+ AMOLED display with a 120Hz refresh rate and an impressive 3840Hz PWM dimming for superior visuals. Under the hood, the smartphone is powered by the Snapdragon 7s Gen 3 processor, coupled with up to 12GB LPDDR4X RAM and 512GB UFS 3.1 storage. It is expected to run on Android 15 with Realme UI 6.0.

For photography, the device offers a triple-camera setup featuring a 50MP Sony IMX896 primary sensor with OIS, an 8MP ultra-wide lens, and a 50MP Sony IMX882 periscope telephoto lens with up to 6x in-sensor zoom. The front houses a 32MP selfie camera.

Additional features include an in-display fingerprint sensor, IP66, IP68, and IP69 water resistance certifications, and a robust 6,000mAh battery with 80W SuperVOOC fast charging.

Realme 14 Pro+ pricing (Expected)

The Realme 14 Pro+ is expected to be priced at approximately Rs 30,000 for the 12GB RAM/256GB storage variant and Rs 33,000 for the 12GB RAM/512GB version, based on its Chinese pricing of 2,599 yuan and 2,799 yuan, respectively.

As more details about the Realme 14 Pro surface, all eyes will be on tomorrow’s launch event for official specifications and pricing.

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