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COVID VACCINE DEVELOPMENT RACE HOTS UP

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American drugmaker Pfizer Inc, which had partnered with German biotech firm BioNTech to develop a vaccine candidate against Covid-19 earlier this year, has become the latest in the list of major movers in the vaccine race to move into the final stages of human trials. Right on the heels of Moderna Therapeutics, Pfizer announced that its vaccine candidate, called BNT162b2 for the time being, has progressed to phase II/III trials.

Like Moderna, Pfizer’s candidate belongs to a category called a messenger RNA vaccine. These types of vaccines involve modifying a messenger RNA to get the cells to recreate the part of the virus that is crucial to target. In this case, the Pfizer-BioNTech vaccine has modified the messenger RNA to instruct the cells in the body to produce the spiky outer surface of the SARS-CoV-2 virus–the spike glycoprotein.

The latest development means that Pfizer will be conducting two stages of clinical trials seamlessly, an approach that intends to shorten the time taken to conduct these tests. The trials will check for the safety and effectiveness of the vaccine in persons between the ages of 18 to 85 years and will be conducted not only in the US, but in 120 sites globally. The duo is targeting 39 states across the US, as well as countries like Argentina, Brazil and Germany.

Coronavirus

Before this, Pfizer-BioNTech had conducted early stage phase I/II trials in the US and Germany. If the late stage trials succeed in showing that the candidate is effective in preventing a person from getting Covid-19, Pfizer and BioNTech will be “on track” to approaching the American drug regulator for approvals as early as October this year.

If approval is given, the firm plans to supply up to 100 million doses by the end of 2020 and around 1.3 billion doses by the end of 2021. BNT162b2 is one of four candidates that Pfizer and BioNTech were investigating as potential vaccines to protect people from getting Covid-19.

Both Bharat Biotech and Cadila are testing one another candidate. Bharat Biotech has joined hands with Thomas Jefferson University in Philadelphia, United States for this other candidate vaccine. It is being developed at the university facilities.

Read Also: COVID VACCINE DEVELOPMENT RACE HOTS UP

Besides these two, Pune-based Serum Institute of India is collaborating with Codagenix, a biotechnology company in New York, to develop a Coronavirus vaccine. Indian Immunologicals Limited, a public-sector company in Hyderabad which produces several animal and human vaccines, is working with Griffith University of Australia to develop a vaccine.

Cadila’s other vaccine is of a different type than the one which has gone into human trials.

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Section 144 imposed in Kolhapur after clashes break out over socmed post with offensive audio message, Tipu Sultan photo  

The Law and order is the state affair and Maharashtra government takes the responsibility of it. He also appeals to the public for peace and calm. Police investigation is under way and action will be taken against those found guilty.

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Kolhapur clash

Prohibitory orders have been issued in Kolhapur on Wednesday banning the assembly of five or more persons till June 19 after clashes broke out between two groups. Right-wing outfits objected to the use of Tipu Sultan’s image along with an objectionable audio message as a social media status put up by a few residents. Police had to lathicharge to disperse the crowd as the situation became tense.

Police have also applied for banning mobile internet from Wednesday till Thursday evening to prevent the issue from snowballing. On Tuesday, a group of right-wing activists held a protest demanding action against those who put the image of the 18th-century Mysore ruler along with an offensive message on their social media profiles. Police assured action and told them to return. Police also informed the protesters they had booked some people in connection with the post.

Kolhapur SP Mahendra Pandit said the protesters again hit the streets on Wednesday. Few organisations had called for a Kolhapur bandh and the members of these organisations gathered at Shivaji Chowk early today. After their demonstration ended, the crowd began to disperse but some miscreants started pelting stones, forcing police to use force against these people to disperse them. The SP also said they appealed to the agitators to maintain peace and withdraw the agitation.

Dipak Kesarkar, guardian minister and minister of education and Marathi language, said action has been taken against those who had used Tipu Sultan’s image along with an objectionable audio message with the detention of 21 people so far.

Maharashtra Chief Minister Eknath Shinde appealed for calm and peace. He said law and order is a state responsibility and the Maharashtra government will act. Police investigation is under way and action will be taken against those found guilty. Maharashtra Deputy CM Devendra Fadnavis said this was part of a larger well-thought out plan by some people.

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UP women fight over garage space; video goes viral | Watch

Over 47,000 people have seen the video since it has been uploaded. People are giving different reactions to the video.

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women fight

With vehicles increasing on the road day by day, it is obvious that space to park them becomes scant. In a video which is going viral, two women from Uttar Pradesh can be seen arguing and attacking each other over what both claim as their garage space.

The woman, who made the video and posted it on social media, can be seen charging the other slightly elderly woman and her husband for using his position to grab the space paid for by the woman making the video.

The video begins with a handyman who is seen breaking the lock of a caged garage space and the woman shooting it can be heard saying she had it built herself. She then threatens the elderly woman that she will post the footage on social media, but the elder woman nor the handymen seem particularly alarmed by it.

When things turn violent, the elderly woman throws broken lock away. The other woman tries to prevent her from doing so and ends up grabbing the elder woman by her neck. The recording ends when the elder woman retaliates by slapping the younger woman several times, leading to her phone falling.

Over 47,000 people have seen the video since it has been uploaded. People are giving different reactions to the video. One user said these are common things in small towns and cities, another said the last slap on the phone was hilarious while others were dropping laughing emojis on it. 

However, these days, such videos showing violence between women have become common on social media. A few days ago, a video from Delhi Metro went viral where two young women got into a heated argument which quickly turned into a fistfight.

The women can be seen preparing for the fight by setting aside their phones as the video begins with one of them taking off her sneaker and brandishing it like a weapon. Other passengers can be heard begging them not to fight.

Parking-related arguments and fights have snatched many lives in the Delhi National Capital Region. Luckily in this video, the violence did not reach such fatal ends.

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Bail too late: 62-year-old man gets relief on humanitarian grounds 2 days after he’s dead

A shocking case has emerged in Mumbai, Maharashtra. A Mumbai court granted bail to an accused two days after his death.

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Court (Representative image)

A Mumbai real estate agent, who had been in jail since December 2021 for selling property with fake documents, has been granted bail but unfortunately Suresh Pawar had died two days before the relief was granted.

The accused had been in jail since December 31, 2021 and had requested six-month temporary bail due to health concerns. Though the hearing on his bail application was completed on May 9 when he was alive, the bail order came two days after his death.

The court granted him temporary bail on humanitarian grounds, looking at his age, medical complications, and further need for medical care.

As per the bail application, he was severely diabetic and was experiencing several age-related ailments. In February, he suffered a toe injury and was taken to JJ Hospital, where he was discharged from. However, he had claimed he needed to have the toe amputated since it had turned gangrenous. His lawyer had moved the plea so that he could undergone treatment at a private hospital.

In March, the Bombay High Court gave directions to jail authorities to provide proper medical treatment, after which he withdrew his bail application from the High Court on April 19.

On the same day, Pawar’s health condition deteriorated, and he was again admitted to JJ Hospital, but due to inappropriate medical treatment, his injury became septic, and his leg below the knee necessarily required to be amputated.

Later, he developed a lung infection and sought temporary bail for a six-month period to avail himself of proper medical treatment.

The prosecution and opponent opposed his plea, arguing that he was being provided with enough medical care at JJ Hospital.

The death of Suresh Pawar will not provoke a thousand searing editorials but is scathing on the apathy and the callousness the State metes out to citizens, even if accused of crime.

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