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Scientists decipher why epilepsy drugs don’t work for some women

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Scientists decipher why epilepsy drugs don’t work for some women

[vc_row][vc_column][vc_column_text]By BhavyaKhullar
Twitter- BhavyaSc

New Delhi, June 13 (India Science Wire): Effective treatment is available for epilepsy, yet doctors find that epilepsy drugs don’t work in some women. Now scientists have figured out why some women suffer from recurrent seizures despite medication.

Scientists at Institute of Genomics and Integrative Biology (IGIB) and Institute of Human Behavior and Allied Sciences (IHBAS), both in New Delhi, have found that a variation in a gene called Cytochrome P4501A1 (CYP1A1) is responsible for some women continuing to suffer from frequent epileptic seizures despite taking one or a combination of known anti-epileptic drugs.  The study results have been published in The Pharmacogenomics Journal.

CYP1A1 gene is known to make an enzyme, that regulates the levels of female hormone estrogen in the blood, which is also important in controlling drug response in epilepsy.“Since this gene is involved in dispersal of estrogen, we thought that perhaps an altered expression of it is contributing to higher levels of estradiol, which, in turn, was increasing susceptibility of women to seizure and causing poor response to drugs. Our studies showed this was indeed so,” researchers explained. The study involved 579 patients with epilepsy, of whom 45% were women.

Based on the study results, the researchers have identified a genetic marker for predicting therapeutic response to drugs in epilepsy.

“Though genetic variation has been studied in other countries with variable results, this study in the Indian context is important. We still are trying to find out best management for intractable seizure. Hopefully the new finding about genetic basis of intractable seizures will lead to some better enzyme regulation in anti-epileptic drugs in future,” commented DrVijayaNath Mishra, professor of neurology at the Institute of Medical Sciences (IMS) BHU, who was not involved in this study.

The research team included P Talwar, N Kanojia, S Mahendru, R Baghel, S Grover, G Arora, GK Grewal, S Parween, A Srivastava, M Singh, S Vig, S Kushwaha, S Sharma, K Bala, S Kukreti, and RitushreeKukreti.  (India Science Wire)[/vc_column_text][/vc_column][/vc_row]

India News

Delhi Palam fire leaves 6 dead, massive rescue operation underway

Six people died after a fire broke out in a residential building in Delhi’s Palam. Firefighters continue rescue efforts with 30 tenders at the spot.

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Delhi's palam

A tragic fire incident in southwest Delhi’s Palam area on Wednesday morning claimed the lives of six people, triggering a large-scale emergency response.

According to officials, the blaze erupted in a residential building, prompting immediate action from fire and police authorities. Around 30 fire tenders were rushed to the spot to control the flames and carry out rescue operations.

Authorities said they received a distress call at approximately 7 am reporting the fire at a house within the building. Firefighters were deployed swiftly amid concerns that several residents could be trapped inside the structure.

A fire services official stated that initial information suggested people might still be inside, leading to an intensive search and rescue effort. Emergency teams, including police personnel, reached the congested locality to assist in evacuation and crowd management.

The firefighting operation was still ongoing at the time of reporting. The exact cause of the fire has not yet been determined, and further details are awaited as authorities continue their investigation.

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Centre mandates 60% free seat allocation on flights, caps selection fees

Airlines must now offer 60% seats without extra charges and ensure better seating arrangements for passengers under new government rules.

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In a significant move aimed at protecting air travellers, the Union Ministry of Civil Aviation has directed airlines to ensure that at least 60 per cent of seats on every flight are offered without any additional selection fee. The decision follows widespread complaints from passengers about hidden charges, particularly for seat selection.

The directive has been issued through the Directorate General of Civil Aviation, which has introduced a series of passenger-friendly norms to enhance transparency and improve the overall flying experience.

Under the new guidelines, airlines have also been instructed to seat passengers travelling on the same PNR together, preferably in adjacent seats. This is expected to address long-standing concerns among families and group travellers, who often face inconvenience due to scattered seating arrangements.

The regulator has further emphasised the need to safeguard passenger rights in situations such as flight delays, cancellations, and denied boarding. Airlines have been asked to prominently display these rights across their websites, mobile applications, booking platforms, and airport counters to ensure better awareness.

In addition, carriers must establish clear and transparent policies regarding the carriage of sports equipment, musical instruments, and pets. The move comes in response to frequent complaints over inconsistent rules and high charges. Airlines have been directed to align such policies with safety and operational standards while ensuring they are communicated in a simple and passenger-friendly manner.

To improve accessibility, the regulator has also asked airlines to share passenger rights information in regional languages.

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Mamata Banerjee warns BJP, EC over Bengal polls, says they will be accountable

Mamata Banerjee holds BJP and Election Commission responsible for any incidents during Bengal polls, raising concerns over officer transfers.

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West Bengal Chief Minister Mamata Banerjee has held the Bharatiya Janata Party (BJP) and the Election Commission of India responsible for any untoward incidents in the state during the upcoming assembly elections, following the transfer of key officials.

Addressing concerns over administrative reshuffles, Banerjee said that changes involving senior bureaucrats, including the chief secretary and home secretary, could affect governance and law and order in the state during a crucial period.

The Trinamool Congress chief also announced candidates for 291 constituencies for the elections scheduled to be held in two phases on April 23 and 29.

Criticising the Election Commission, Banerjee alleged that the transfers were being carried out in a manner that benefits the BJP. She questioned the timing of the decisions and said such actions weaken the state administration at a sensitive time.

She further raised concerns about disaster management and essential services, stating that experienced officials familiar with the state’s situation have been replaced. According to her, this could impact administrative efficiency if any emergency arises before the new government is formed.

Protecting Bengal’s identity

Banerjee emphasised that the election is not merely about forming a government but about safeguarding Bengal’s identity and existence. She accused the BJP of misusing central agencies and attempting to influence the electoral process.

She urged that elections should be conducted peacefully, without external interference, and in line with democratic principles. The chief minister also expressed confidence that her party would return to power with a stronger mandate.

Appealing to voters, she called for support for the Trinamool Congress, asserting that the people of Bengal will ultimately decide the outcome and protect their democratic rights.

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