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Study identifies genetic link to heart disease in Indian population

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Study identifies genetic link to heart disease in Indian population

[vc_row][vc_column][vc_column_text]~By Ratneshwar Thakur

About 35 to 40 percent Indians carry a set of genetic variations which puts them at higher risk of heart disease, finds a new study.

A team of Indian researchers has discovered that carriers of a set of genetic variants in the Chromogranin A (CHGA) gene called ‘CHGA promoter haplotype2’ may be at higher risk for cardiovascular and metabolic disorders. An estimated 35 to 40 percent of Indian population may be carrying this genetic variant.

The study is based on analysis of genomic DNA samples from over 750 individuals from Indian population. The research findings have been published in Journal of Biological Chemistry.

Study identifies genetic link to heart disease in Indian population

Research team at IIT-Madras.

Though the CHGA promoter haplotype is present in other ethnic populations, it occurs more frequently in populations of South Asian ancestry. “It is a protein of neuroendocrine origin and is secreted along with hormones like catecholamines. Earlier studies had suggested its role in regulation of cardiovascular and metabolic diseases but there was no data about it in South Asian populations,” said Lakshmi Subramanian, first author of this paper.

“Westudied genomic DNA of Indians and discovered a specific set of changes in the CHGA genesequence called Haplotype2 which contributed to increased CHGA gene expression, and ultimately increased CHGA protein levels in plasma. When the clinical parameters of those in the study were compared, Haplotype2 carriers displayed higher levels of metabolic and cardiovascular traits like plasma glucose, blood pressure and body mass index,” explained Dr. Nitish R Mahapatra, Professor at IIT-Madras.

However, he said, these results need further validation in animal models as well as large-scale studies in individuals with metabolic syndrome. “We hope these findings would help unravel biological pathways and mechanisms underlying these complex diseases and would help in the development of therapeutic as well aspreventive strategies,” said Dr. Mahapatra.

“Basic research in cardiovascular biology is in a very nascent stage in India with only a handful of researchers working in this field. This new study significantly contributes towards understanding molecular basis of cardiovascular and metabolic diseases. This is a fast emerging area with tremendous therapeutic and diagnostic potential,” commented Dr Shyamal K Goswami, a professor at School of Life Science, JNU, who is not connected with the study.

The study was led by Dr Nitish R Mahapatra at Indian Institute of Technology -Madras, Chennai, in a collaborative effort with Dr Ajit S Mullasari at Madras Medical Mission, Chennai, and Dr. Madhu Khullar at PGIMER, Chandigarh. (India Science Wire)[/vc_column_text][/vc_column][/vc_row]

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Elon Musk’s SpaceX eyes for its first orbital launch to reach Mars via spacecraft, here’s the first glimpse | WATCH

In September 2019, Musk had announced that SpaceX aimed to fly people to Mars by 2024. The Starship spacecraft will be capable of carrying about 100 people at a time and the company aimed to launch its first orbital test flight within the next six months, Musk had also said during his presentation.

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Elon Musk

Elon Musk’s SpaceX is looking for its first orbital launch to reach Mars via spacecraft. The billionaire founder, who has revolutionised commercial space travel, has now released a simulation of what the journey to Mars will look like.

This will be real in our lifetime, Musk tweeted after releasing the Martian simulation.

Last week, the billionaire had released the details about the development of Starship, the world’s most powerful rocket ever built.

Standing alongside the 390-foot (119-meter) rocket at SpaceX’s Texas spaceport, Musk had also said let’s make this real! This is really some wild stuff here. In fact, hard to believe it’s real.

In September 2019, Musk had announced that SpaceX aimed to fly people to Mars by 2024. The Starship spacecraft will be capable of carrying about 100 people at a time and the company aimed to launch its first orbital test flight within the next six months, Musk had also said during his presentation.

Elong Musk has estimated that the Starship launch could wind up costing less than $10 million.

From the beginning of the year 2022, the SpaceX has been ramping up operations with its workhorse Falcon-9. The company has also been launching Starlink constellations and cargo to the International Space Station.

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Latest Science News

Stephen Hawking birth anniversary: Google Doodle pays tribute to legendary scientist

Hawking is mainly known for his theories on black holes. He revolutionized the modern physics with his theories on origins and mechanics of the universe. His intellectual and curiosity about new things, earned him a nickname Einstein.

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Death embraces Stephen Hawking, visionary scientist who never believed in afterlife

Stephen Hawking the legendary scientist and theoretical physicist would be celebrating his 80th birth anniversary. To mark the special day, search engine company Google paid tribute to the English cosmologist and author with a two and half minutes long animated video on their homepage.

Born in Oxford, England, Stephen Hawking was fascinated by the universe from a very young age. However, Hawking was diagnosed with a rare disease named neurodegenerative when he was just 21 years old. The disease slowly forced him to sit on a wheelchair. As the time passed, he started losing his voice and after a while he lost his speech. Therefore, he started to communicate through a speech generating device, which was invented by himself. Google describes the legendary scientist as ‘one of history’s most influential scientific minds’.

Hawking is mainly known for his theories on black holes. He revolutionized the modern physics with his theories on origins and mechanics of the universe. His intellectual and curiosity about new things, earned him a nickname Einstein.

In 1965, Hawking defended his PhD thesis on ‘Properties of Expanding Universe’ at the Cambridge University. The revolutionary theory presented that space and time originated from a singularity.

Here are some of the best quotes by Stephen Hawking

  1. One, remember to look up at the stars and not down at your feet. Two, never give up work. Work gives you meaning and purpose and life is empty without it. Three, if you are lucky enough to find love, remember it is there and don’t throw it away.
  2. Quiet people have the loudest minds.
  3. Intelligence is the ability to adapt to change.
  4. The victim should have the right to end his life, if he wants. But I think it would be a great mistake. However bad life may seem, there is always something you can do, and succeed at. While there’s life, there is hope.
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Education

IIT Kanpur 54th Convocation: Prime Minister Narendra Modi launched blockchain-based digital degrees

The 54th convocation ceremony of the Indian Institute of Technology (IIT) Kanpur was held today. A total of 1723 students received their diplomas, with three eminent individuals receiving honorary doctorate degrees. Prime Minister Narendra Modi was also present there in the convocation ceremony.

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IIT Kanpur 54th Convocation: Prime Minister Narendra Modi launched blockchain-based digital degrees

The 54th convocation ceremony of the Indian Institute of Technology (IIT) Kanpur was held today. A total of 1723 students received their diplomas, with three eminent individuals receiving honorary doctorate degrees. Prime Minister Narendra Modi was also present there in the convocation ceremony.

At the 54th convocation ceremony of the Indian Institute of Technology (IIT), Kanpur’s primary guest was Prime Minister Narendra Modi. The governor of Uttar Pradesh, Anandiben Patel, and the Chief Minister of Uttar Pradesh, Yogi Adityanath, were honoured as the guests at the event.

The 54th convocation of IIT Kanpur was organized in a hybrid format, with the institution ensuring. An aggregate of 1,723 students got their diplomas, with 880 of them attending convocation in person on campus and the rest participating online or over the phone.

All candidates received digital degrees based on a blockchain-based system created in-house at IIT Kanpur as part of the National Blockchain Project.

Prime Minister Narendra Modi has announced the establishment of blockchain-based digital degrees. These digital degrees are irreversible and may be recognized worldwide. In certain states, the same technology is being utilized to implement land records.

Prime Minister Narendra Modi said that this is entirely technologically based. Even in this decade, people should know how to continue to expand their hegemony in a variety of industries. In some ways, life would be incomplete without knowledge. This is the age of life’s and knowledge’s competitors.

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