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Blood test possible to diagnose liver fibrosis: new study

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AIIMS

By Bhavya Khullar

Doctors have long been using biopsy to diagnose liver fibrosis. A new study says it may be possible to diagnose the liver disease with a blood test in future.

Researchers at the All India Institute of Medical Science (AIIMS), New Delhi, working in collaboration with Justus Liebig University, Giessen in Germany, have identified diagnostic markers for liver fibrosis. With these markers, it will be possible to diagnose liver fibrosis from blood samples. It will make diagnosis easier to perform, non-invasive, and less prone to sampling errors, researchers say in their study published in journal Clinical and Translational Gastroenterology.

The new study has reported that patients of liver fibrosis have elevated levels of two proteins- Cathepsin L and Cathepsin B – in liver tissues as well as blood plasma, compared to healthy people. The increased levels of these two proteins open the possibility of designing a new and better diagnosis for liver disease. There is progressive increase in concentrations of the two proteins with advancement in the stages of liver cirrhosis, making them potential diagnostic tools.

The observation was first made in animals and then humans. It was seen that the two proteins are elevated in kidney, heart, and lung fibrosis, which led to the idea of testing their diagnostic relevance in liver disorder. Since the findings are based on blood samples from 51 patients, researchers have recommended studies involving larger group of patients to further validate their work.

However, an expert working in the same field pointed out that “previous studies have also reported biomarkers for liver fibrosis. The challenge is to find a marker that can differentiate between mild and severe stages of the disease in addition to distinguishing between healthy and severely ill conditions.”

Liver fibrosis is caused by several factors including alcohol consumption, viral infection, and metabolic disorders. It is also congenital in some cases. It is marked by the formation of scars and nodules in the liver, which is due to accumulation of specific proteins.

The study team included Mansi Manchanda, Prasenjit Das, Gaurav Gahlot, Ratnakar Singh, Elke Roeb, Martin Roderfeld, Siddhartha Datta Gupta, Anoop Saraya, R M Pandey and Shyam S Chauhan.(India Science Wire)

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National Herald row reignites BJP-Congress face-off amid ED chargesheet

BJP has reignited its attack on the Gandhi family, accusing them of a corporate conspiracy in the National Herald case, while Congress dismisses the ED action as a political vendetta by the Modi government.

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A political slugfest has erupted once again between the Bharatiya Janata Party (BJP) and the Congress following the Enforcement Directorate’s (ED) chargesheet naming Sonia Gandhi and Rahul Gandhi in the alleged money laundering case tied to the now-defunct National Herald newspaper. The BJP has termed the case a textbook example of “corporate conspiracy,” while the Congress has decried the move as an act of “political vendetta” by the Narendra Modi-led central government.

BJP questions Gandhi family’s property acquisition through Young India Ltd

Senior BJP leader Ravi Shankar Prasad, addressing a press briefing, accused the Congress of orchestrating a corporate arrangement to transfer property into the Gandhi family’s hands. He highlighted that in 2008, after the National Herald ceased publication, the Congress gave ₹90 crore to Associated Journals Limited (AJL), the newspaper’s publisher — a transaction he claims violates the norms as political parties are barred from funding private entities.

AJL reportedly failed to repay the loan, after which a non-profit entity, Young India Limited (YIL) — in which Sonia and Rahul Gandhi each hold a 38% stake — acquired the company’s shares and, by extension, its properties across several Indian cities. Mr. Prasad questioned YIL’s charitable work and highlighted that a token amount of ₹50 lakh was paid to AJL before the remaining loan was written off.

“This is the Gandhi model of development,” Prasad said, alleging that the arrangement enabled the Gandhi family to take control of property worth thousands of crores.

BJP expands attack to Robert Vadra

The BJP leader also took aim at Priyanka Gandhi Vadra’s husband, Robert Vadra, citing alleged irregularities in land transactions. “Another member buys land for ₹3 crore and sells it for ₹58 crore. The country should learn from this Gandhi model,” he remarked sarcastically.

Congress fights back, terms case a political smokescreen

The Congress has launched protests across the country in response to the BJP’s remarks and the ED’s chargesheet. Senior leader Pawan Khera likened the current actions to pre-Independence times, stating, “Back then, the British hated National Herald, the Gandhi family and the Congress — today the RSS has taken that place.”

Calling the case baseless, Congress leader Sachin Pilot said, “There has been no exchange of funds or transfer of property rights. This case is politically motivated, and the Modi government is attempting to silence the voice of the Opposition.” He affirmed that the party has full faith in the judiciary and will fight the case legally.

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Priyanka Gandhi accompanies Robert Vadra to ED office for second day in Gurugram land probe

Robert Vadra, husband of Congress MP Priyanka Gandhi, appeared before the ED for the second day in the Gurugram land case.

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Robert Vadra Priyanka Gandhi

Congress MP Priyanka Gandhi Vadra accompanied her husband Robert Vadra to the Enforcement Directorate (ED) office on Wednesday as he appeared for questioning for the second consecutive day in connection with the Gurugram land case.

Mr Vadra, the brother-in-law of Lok Sabha Leader of Opposition Rahul Gandhi, was seen exchanging a hug with Ms Gandhi before entering the ED office. He is under scrutiny in a money laundering probe linked to a 2008 land deal in Manesar-Shikohpur area, now known as Sector 83 of Gurugram.

Focus of the probe: land deal from Congress tenure in Haryana

The investigation stems from a land transaction executed by Skylight Hospitality Pvt Ltd, a company in which Mr Vadra was formerly a director. In February 2008, Skylight purchased 3.5 acres of land from Onkareshwar Properties for ₹7.5 crore. At that time, Haryana was governed by a Congress-led administration under then Chief Minister Bhupinder Singh Hooda.

In September 2012, four years after the acquisition, Skylight sold the same land to real estate developer DLF for ₹58 crore. The deal later drew public attention after senior IAS officer Ashok Khemka, who was then heading the Land Consolidation and Land Records department in Haryana, cancelled the land mutation, citing violations of the State Consolidation Act and procedural discrepancies.

Haryana Police registered an FIR to examine the deal in 2018, further intensifying the legal scrutiny.

ED questions Vadra under PMLA

On Tuesday, Mr Vadra was questioned for nearly five hours by the ED under the Prevention of Money Laundering Act (PMLA), during which his statement was recorded. The businessman has consistently maintained that the case is part of a political vendetta and emphasized that he has cooperated fully with all investigative agencies, submitting numerous documents over the years.

Calling for a closure to what he described as a decades-old matter, Mr Vadra said cases like these should not be allowed to drag on indefinitely.

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Congress slams PM Modi, Amit Shah after ED files chargesheet against Sonia Gandhi, Rahul Gandhi

The ED’s chargesheet has accused the Congress leaders of money laundering under Sections 3 and 4 of the Prevention of Money Laundering Act.

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The Congress on Tuesday hit out at Prime Minister Narendra Modi and Union Home Minister Amit Shah after the Enforcement Directorate’s (ED) chargesheet against Sonia Gandhi, Rahul Gandhi, and others in the National Herald case.

Labelling it a blatant act of vendetta politics, the grand old party also condemned the seizure of the newspaper’s assets as a “state-sponsored crime disguised as justice,” vowing to fight back against what it calls an attempt to silence its leadership.

In a fiery statement on X, Congress general secretary in charge of communication Jairam Ramesh accused PM Modi and Shah of orchestrating a campaign of intimidation. “Filing chargesheets against Sonia Gandhi, Rahul Gandhi, and others is nothing but the politics of vendetta gone wild,” Ramesh posted. “Seizing National Herald’s assets is a mockery of the rule of law.”

Hitting out at Shah, the Congress leader accused him of going “completely berserk.” He asserted that the Indian National Congress and its leadership refuse to be silenced, stating: “Satyameva Jayate.”

The ED’s chargesheet has accused the Congress leaders of money laundering under Sections 3 and 4 of the Prevention of Money Laundering Act.

Alongside Sonia and Rahul, it names Congress figures Suman Dubey and Sam Pitroda. Special Judge Vishal Gogne reviewed the document for cognisance, scheduling further proceedings for April 25, with the filing handled by ED’s special public prosecutor, N.K. Matta.

Ramesh asserted that the Congress remains undeterred, promising, “We will not be silenced, and the truth will triumph.” The chargesheet reignites a long-standing legal battle tied to the National Herald, a newspaper associated with the Congress since India’s independence era.

The Delhi Rouse Avenue Court has scheduled a hearing for arguments on the ongoing National Herald case for April 25, 2025.

During a recent session, the presiding judge stated, “The present prosecution complaint shall next be taken up for consideration on the aspect of cognisance before this court on April 25, 2025, when the special counsel for the ED and the investigating officer will ensure the production of case diaries for the court’s examination.”

The prosecution complaint, lodged under Sections 44 and 45 of the Prevention of Money Laundering Act (PMLA) of 2002, pertains to allegations of money laundering, as outlined in Section 3, in conjunction with Section 70, and is punishable under Section 4 of the same act, as per the report.

This case has garnered significant attention, following a complaint filed by BJP leader Subramanian Swamy against Congress leaders Sonia and Rahul, their associated companies, and other individuals involved.

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