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Indian-made Gene therapy shows 73% response rate in blood cancer trials

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An indigenously developed gene therapy for specific blood cancers has demonstrated a 73% response rate in clinical trials, offering new hope for patients in India. The findings, published in The Lancet Haematology, highlight the success of CAR T-cell therapy, which modifies a patient’s immune cells to combat cancer.

A breakthrough in cancer treatment

The therapy was developed through a collaboration between the Indian Institute of Technology-Bombay (IIT-B) and Tata Memorial Hospital, Mumbai. It has been designed to treat patients with relapsed or refractory B-cell malignancies, including leukemia and lymphoma, which often have poor outcomes due to limited treatment options.

Speaking on the impact of this therapy, Rahul Purwar, lead author and IIT-B professor, stated,

“The clinical trials of India’s first gene therapy for cancer offer hopes of another chance to live among these patients, that there is one more drug that doctors can try.”

Affordable alternative to global therapies

Unlike CAR T-cell therapies in developed nations, which cost between $373,000 to $475,000, the India-made injection ‘talicabtagene autoleucel’ is available for $30,000—making it significantly more affordable.

Developed over 11 years, the therapy was tested in two trial phases:

  • Phase 1: Included 14 patients (18+ years) with B-cell lymphoma.
  • Phase 2: Expanded to 50 patients (15+ years) with B-cell leukemia or lymphoma.

Among the 51 patients analyzed, the overall response rate was 73%, with two treatment-related deaths. Common side effects included neutropenia (low white blood cell count), thrombocytopenia (low platelet count), and anemia.

Future scope and clinical advancements

Dr. Hasmukh Jain, a medical oncology professor at Tata Memorial Hospital, emphasized the long-term benefits of CAR T-cells in preventing cancer relapse. He noted that new trials are underway to test the therapy in earlier settings and in combination with other immunotherapies at Tata Memorial Centre.

Bollywood news

Hrithik Roshan’s Krrish 4 in trouble? Siddharth Anand exits, Rakesh Roshan steps back from direction

Krrish 4 faces another delay as Siddharth Anand exits and Rakesh Roshan steps back from direction. Budget concerns continue to stall the superhero project.

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The much-anticipated Bollywood superhero film Krrish 4, starring Hrithik Roshan, has hit another roadblock as director Siddharth Anand and his banner Marflix have exited the project. Reports indicate that the film’s budget, reportedly touching ₹700 crore, has made it difficult for production houses to move forward with the project.

Adding to the uncertainty, Rakesh Roshan, who directed the previous installments of the Krrish franchise, has decided to step away from directing the film, choosing to “pass on the baton” to a new director.

Production struggles continue

Krrish 4 has faced multiple delays over the years, and with the exit of Siddharth Anand, the situation has become even more complicated. Hrithik Roshan, who had wanted Anand to direct, is now left looking for a new team to take the project forward.

Although there are reports suggesting that the film’s ₹700 crore budget is the reason for the hurdles, another source has denied these claims, stating that the “astronomical figures doing the rounds are completely untrue.”

New production plans in motion

While Marflix will no longer be part of the film, FilmKraft, the production house owned by the Roshan family, is reportedly looking for a new studio to back the film. With no director or confirmed production house in place, it remains to be seen how and when the film will move forward.

For now, Krrish 4 remains in limbo, with fans eagerly waiting for an official update on its future.

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Cricket news

IML final: West Indies Masters get bigger prize money despite finishing as runners-up, check prize money

India Masters clinched the IML 2025 title, winning ₹1 crore in prize money, while West Indies Masters secured ₹5 crore for finishing runners-up.

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Sachin Tendulkar’s India Masters emerged victorious in the inaugural International Masters League (IML), defeating Brian Lara’s West Indies Masters by six wickets in the final. The match, played with intense competition despite featuring retired cricketers, saw India dominate from the start, thanks to a stellar bowling performance by Shahbaz Nadeem and a match-winning knock from Ambati Rayudu.

Prize money breakdown

The India Masters, featuring cricket legends like Yuvraj Singh, Yusuf Pathan, and Irfan Pathan, were awarded a cash prize of ₹1 crore for their triumph. Surprisingly, the West Indies Masters, despite finishing as runners-up, took home a higher prize amount of ₹5 crore.

Ambati Rayudu Shines in the Final

Ambati Rayudu played a crucial role in India’s victory, scoring 74 runs off 50 balls, earning him the Player of the Match award along with a cash prize of ₹50,000.

Full List of Award Winners

Match Awards

Player of the Match: Ambati Rayudu (74 runs off 50 balls) – Rs 50,000

Masterstroke of the Match: Ambati Rayudu (9 fours) – Rs 50,000

Most Sixes in the Match: Ambati Rayudu (3 sixes) – Rs 50,000

Gamechanger of the Match: Shahbaz Nadeem (2/12 in 4 overs)

Most Economical Bowler: Shahbaz Nadeem (economy rate of 3.00)

Season Awards

Most Fours in the Season: Kumar Sangakkara – 38 fours (Rs 5 lakh)

Most Sixes in the Season: Shane Watson – 25 sixes (Rs 5 lakh)

The tournament saw heated moments, including a verbal altercation between Yuvraj Singh and Tino Best, proving that even legends still bring passion and intensity to the game.

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Bollywood news

Kangana Ranaut’s Emergency tops Netflix, sparks debate over Oscars

Kangana Ranaut’s ‘Emergency’ is the #1 trending movie on Netflix. She calls the Oscars “silly,” stating that America wouldn’t acknowledge the film’s political message.

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Kangana Ranaut’s latest film, Emergency, has taken the top spot on Netflix India, making it the #1 trending movie on the platform. The film, which portrays the events of the 1975 Emergency in India with Ranaut playing former Prime Minister Indira Gandhi, has garnered widespread praise.

However, when a social media user suggested that the film should be India’s entry for the Oscars, Ranaut had a bold response, dismissing the Academy Awards as “silly.”

Kangana Ranaut’s take on the Oscars

A fan on Twitter wrote, “#EmergencyOnNetflix should go for the Oscars from India. Kangana, what a film.” In response, Ranaut reposted the tweet, stating:

“But America wouldn’t like to acknowledge its real face, how they bully, suppress, and arm-twist developing nations. It’s been exposed in #Emergency. They can keep their silly Oscar. We have National Awards.”

Her remarks come amid growing recognition for the film, which she directed, produced, and starred in.

Filmmaker Sanjay Gupta praises ‘Emergency’

Despite initial skepticism, filmmaker Sanjay Gupta was highly impressed by the film. Sharing his thoughts, he tweeted:

“Today I watched EMERGENCY by @KanganaTeam. Very frankly I wasn’t planning to as I had prejudged it. I am so glad that I was wrong. What a fantastic film by Kangana—both performance & direction. Top Notch & World Class.”

Ranaut acknowledged his praise, calling for the industry to shed its “hate and prejudices” and judge films based on merit rather than preconceived notions.

Ranaut on her performance in ‘Emergency’

Many fans have lauded her acting in the film, with some calling it her best performance to date, surpassing her acclaimed roles in Queen, Tanu Weds Manu Returns, Fashion, and Thalaivi.

In response, Ranaut said:

“People are calling my acting in #Emergency amazing and my best ever. Could I surpass Queen, TWM2, Fashion, Thalaivi? Watch #Emergency and find out.”

Emergency tops Netflix charts

Released on March 15, 2025, Emergency has climbed to the #1 spot on Netflix India’s movies list, ahead of Ajay Devgn’s Azaad and Naga Chaitanya-Sai Pallavi’s Thandel.

Apart from Kangana Ranaut, the film features a stellar cast including Anupam Kher, Shreyas Talpade, Vishak Nair, Milind Soman, and the late Satish Kaushik. Produced by Zee Studios and Manikarnika Films, the film offers a dramatic retelling of the 21-month Emergency period imposed in 1975.

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