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Hope brightens for corona vaccine.

Oxford University has initiated a phase-1 human clinical trial of its vaccine against the novel coronavirus, SARS-CoV-2. A single dose of the candidate vaccine will be administered to 1,112 healthy volunteers to study the safety, ability to produce immune response and efficacy of the vaccine.

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Oxford University has initiated a phase-1 human clinical trial of its vaccine against the novel coronavirus, SARS-CoV-2. A single dose of the candidate vaccine will be administered to 1,112 healthy volunteers to study the safety, ability to produce immune response and efficacy of the vaccine. Oxford University is optimistic of a positive outcome of the candidate vaccine and has planned to get millions of doses of the vaccine before the end of the year even as results of the final phase of the trial are awaited.

The proposed vaccine for corona virus by Oxford University uses the common cold virus, adenovirus, that causes infections in chimpanzees. The adenovirus has been genetically altered so that it does not grow once injected. The construct carries the genetic material of the novel coronavirus that makes the spike protein. The spike protein is found on the surface of the virus and plays a crucial role in binding to specific human receptors found on cell surfaces and entering the cells.

By introducing the genetic material of the spike protein, the candidate vaccine will help the body recognise it and make antibodies against the spike protein. The antibodies produced will help mount an immune response and prevent the virus from entering the human cells and causing an infection.

Oxford University has used vaccines made from the adenovirus construct to over 320 people and has found it to be safe and well tolerated. It does cause transient side effects such as fever, headache or a sore arm but is otherwise safe.

The safety of the candidate vaccine was earlier tested on six rhesus macaque monkeys. A single dose protected all the six animals for nearly a month even when exposed to high levels of the virus, boosting the confidence of the researchers.

Up to 1,112 healthy volunteers have been recruited for the phase-1 trial. Volunteers, both male and female between 18-55 years, are being recruited for the trial. A single dose of the candidate vaccine will be administered to volunteers.  The university researchers will also be testing two doses of the candidate vaccine given four weeks apart on a small group of 10 volunteers to assess the dosage and immune response.

The phase-1 trial is expected to be completed by May-end if transmission remains high in the community. The phase-2 trial may be completed by August-September. In fact, phase-2 and phase-3 trials may get combined if the phase-1 trial results are encouraging.

Pune’s Serum Institute, a partner in the project, has said that the company will start manufacturing the vaccine the moment the phase-3 trial or the combined phase-2/phase-3 trial begins. If the last two stages of the trial are combined then it would start manufacturing the vaccine by June-end and be ready with millions of doses by the end of the year. The company is confident of manufacturing 60-70 million vaccine doses by the end of the year.

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Dust storm, light rain expected in Delhi-NCR today, heatwave conditions to abate

IMD claimed in a tweet that Thunderstorm dust with light to moderate intensity rain and gusty winds with speed of 30-50 km/hr would occur over and adjoining areas of many places of Delhi, North Delhi, North East Delhi, North west Delhi, West Delhi, Central Delhi, East delhi and NCR( Loni Dehat, Hindon AF station, Ghaziabad, Indrapuram, Chapraula) Sonipat, Rohtak, Kharkhoda (Haryana) Baraut, Bagpat, Meerut, Khekra, Modinagar, Kithor , Garhmukhteshwar, Pilakhua, Hapur ,Gulaoti ,Siyana ,Sikandrabad , Bulandshahr ,  Jahangirabad (UP)

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Dust storm, light rain expected in Delhi-NCR today, heatwave conditions to abate

On Wednesday, a dust storm with light to moderate rain is expected in numerous locations in Delhi and the National Capital Region (NCR). The India Meteorogical Department (IMD) stated the city’s maximum and minimum temperatures are predicted to be in the range of 40 and 25, respectively.

The IMD tweeted an advisory that thunderstorms, dust with light to moderate intensity rain and gusty winds with speed of 30-50 km/hr would occur over and adjoining areas of many places of Delhi, North Delhi, North East Delhi, North West Delhi, West Delhi, Central Delhi, East Delhi and NCR (Loni Dehat, Hindon AF station, Ghaziabad, Indirapuram, Chapraula) Sonipat, Rohtak, Kharkhoda (Haryana), Baraut, Bagpat, Meerut, Khekra, Modinagar, Kithor, Garhmukhteshwar, Pilakhua, Hapur, Gulaoti, Siyana, Sikandrabad, Bulandshahr, Jahangirabad (UP).

For the next two hours, light to moderate intermittent rain is expected over and near Adampur, Hissar, Hansi, and Meham (Haryana).

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On Thursday, May 18, light rain is predicted for in Delhi based on the seven-day prediction for the city. The sky will mainly be cloudy, with the potential of a light  rain or drizzle, according to the weather office.

The air quality will continue to be deteriorated in the city after strong winds with dust swept across the Delhi-NCR on Tuesday. Following this, visibility had reduced to 1000 metres. Kuldeep Srivastava, the head of regional forecasting centre, said the dry atmosphere is one of the reasons for the dust storms.

Following Tuesday’s severe winds and dust storm that blasted across the Delhi-NCR, the city’s air quality had taken an alarming dip.

The monsoons, which are awaited across India, are likely to make landfall in Kerala on June 4. Usually, the monsoon arrives on May 31 or June 1 but the delay will be made up as the phenomenon progresses on its south-west to north-east arc. With extreme temperatures right from a cold sytart to May to dust-laden winds in mid-May, the weather in the country is paying the price for accelerating climate change.

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Security lapse at Navjot Singh Sidhu’s Patiala home, says it will not deter him from raising his voice against Punjab

After his release from jail, he slammed the ruling Aam Aadmi Party (AAP) government for its law and order in the state.

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Navjot Singh Sidhu

Congress leader Navjot Singh Sidhu has filed a complaint with the Punjab Police after he spotted a suspicious person wrapped in a grey blanket on his terrace. He alleged a security lapse at his Patiala home. He couldn’t catch him as he fled after his servant raised an alarm.

Taking to Twitter, Sidhu said, Today on the terrace of his residence an unknown suspicious character wrapped in a grey blanket was noticed around 7:00 pm, the moment his servant went out raised the alarm, and called for help, he immediately ran and escaped.

The 59-year-old further said that he has spoken to DGP Punjab Police and has also informed SSP Patiala. He said the security lapse will not deter him from raising his voice for Punjab.

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Punjab Police registered a case in this matter. According to the reports, the Patiala Senior Superintendent of Police Varun Sharma visited his residence after the complaint and is currently investigating the matter. The CCTV footage of the area is also being scanned, reports state.

Cricketer-turned-politician came out of the Patiala Central Jail on April 1 after serving nearly 10 months in a 1988 road rage case. After his release from jail, he slammed the ruling Aam Aadmi Party (AAP) government for its law and order in the state.

He said Democracy is in chains. Punjab is the shield of this country. When dictatorship came in this country, a revolution also came, led by Rahul Gandhi.

Sidhu also slammed the Mann government over the pruning of security of slain singer Sidhu Moosewala and also making it public.

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Air India Delhi-San Francisco flight suffers tech glitch before take-off, returns to stand

The airline has not given any official statement in this matter.

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Air India Flight

Air India flight which was en route to San Francisco from Delhi on Monday had to be returned to the stand because of a technical glitch. The San Francisco-bound flight suffered a tech issue before take off.

According to the reports, the aircraft which was carrying over 200 passengers from Delhi’s Indira Gandhi International Airport (IGI) had to be replaced with another aircraft. Later, the passengers were accommodated in another aircraft.

The airline has not given any official statement in this matter.

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Earlier today, another Air India incident occurred where a London-bound flight returned to Delhi’s IGI airport after a mid-air brawl between an unruly passenger and the flight’s cabin crew.

A brawl ensued between a passenger and the crew members shortly after it departed from the airport at around 6:35 am. The onboard ruckus forced the plane to turn around and return to Delhi again where the raucous passenger was deboarded and handed over to the police at the airport.

Air India apologized to the passengers on the affected Delhi-London flight for the delay and inconvenience caused to them due to the incident and assured them that efforts will be made to ensure such incidents do not occur in the future.

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