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Just tweaking time of administration can make cancer drugs more effective

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Just tweaking time of administration can make cancer drugs more effective

~By Sarah Iqbal

Just by changing the time of administering drugs, doctors may be able to improve outcome of cancer therapy, suggests new research done at the Indian Institute of Technology-Madras (IITM).

This work is rooted in rhythms of reactive species production. In the course of day-to-day life, all life forms produce highly reactive molecules called reactive species. While small doses of these molecules can aid biological functions, when produced at high rates, they can also kill the cell by creating oxidative stress. Most cancer drugs seek to kill malignant cells by producing rapid bursts of reactive species. But because there is a lack of specific action, drugs also end up affecting normal cells surrounding cancerous tumours.

Just tweaking time of administration can make cancer drugs more effective

Variation in internal reactive species production has been a neglected area of research. The research team at IITM led by GK Suraishkumar has found that there’s a lot of fluctuation in levels of reactive species within a cell. These short-term fluctuations can be ignored when one is studying a much slower process such as cell growth, and work with average levels instead.

Cancer therapy relies on increasing oxidative stress beyond a critical point. Therefore, the timing of internal rhythms in reactive species production is crucial. Scientists found that two important reactive species used for targeting cancer cells – superoxide radicals and hydroxyl radicals – peak at an interval of 15.4 hours and 25 hours respectively.

They reasoned that by aligning drug administration with internal rhythms of reactive species production, the efficiency of drugs could be increased. To test this hypothesis, they administered two drugs menadione and curcumin to cervical cancer cell lines and a colon cancer cell line.

Just by changing the timing of drug administration, researchers could reprogram internal rhythms of reactive species production. For instance, treating cancer cells with curcumin at the time of increased superoxide production ensured that the superoxide radical would peak after every 9 hours. By tuning drug dose to hydroxyl radical production, the periodicity of its rhythm was reduced from 25 hours to 11 hours. This, in turn, improved the drug efficiency by 20%.

The strategy is noninvasive and can be extended to any cancer drug that operates via production of reactive species. The researchers are now planning to extend this to patients. “All we will have to do is change the timing of treatment in tune with the peaking of reactive species production,” explained Suraishkumar while speaking to India Science Wire. “We believe that doing so will also reduce the complications associated with cancer treatment.”

The research team also included  Karunagaran, Raghunathan Rengaswamy, Uma Kizhuveetil, Meghana Palukuri, Prerna Bhalla and Steffi Jose. The research project is financially supported by the Science and Engineering Research Board of the Department of Science and Technology (DST). (India Science Wire)

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Astronaut Shubhanshu Shukla to meet PM Modi after return from historic space mission

Astronaut Shubhanshu Shukla, who recently returned from the ISS as part of the Axiom-4 mission, will meet PM Modi this evening. Parliament will also hold a special discussion on his historic journey.

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Indian astronaut Group Captain Shubhanshu Shukla, the first Indian to visit the International Space Station (ISS), will meet Prime Minister Narendra Modi this evening at his official residence in New Delhi.

PM Modi to host meeting with astronaut

According to officials, the meeting at 7 Lok Kalyan Marg is expected to take place between 5 pm and 5:30 pm. Shukla, who arrived in India on Sunday, will also be part of the National Space Day celebrations scheduled for August 23.

Warm welcome in India

The astronaut was greeted at the airport by his family, Science and Technology Minister Jitendra Singh, Delhi Chief Minister Rekha Gupta, and hundreds of citizens waving the national flag. Shukla had been in the United States for a year, preparing for the Axiom-4 mission, which launched from Florida on June 25 and docked at the ISS the next day. He served as the mission’s pilot.

Emotional note from Shukla

Before his return, Shukla shared an emotional post on Instagram, expressing mixed feelings of leaving his space colleagues while being eager to meet his loved ones and people of India. He also quoted a song from the film Swades, which he had chosen as his anthem on the launch day.

Parliament session on India’s space journey

In honour of Shukla’s mission, the Lok Sabha is holding a special session today to discuss “India’s first astronaut aboard the ISS – critical role of space programme for Viksit Bharat by 2047.” Union minister Kiren Rijiju said the discussion would highlight the importance of India’s space achievements and future goals.

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Shubhanshu Shukla pens emotional note as he returns to India after space mission

Indian astronaut Shubhanshu Shukla penned an emotional Instagram post as he returned to India after his 18-day ISS mission, marking a milestone in India’s space journey.

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Indian astronaut Group Captain Shubhanshu Shukla has shared an emotional Instagram post as he heads back home after completing his 18-day mission aboard the International Space Station (ISS).

Astronaut reflects on mixed emotions

In his heartfelt message, written from the aircraft, Shukla expressed the whirlwind of emotions he felt while leaving behind his fellow astronauts, who had been his family during the mission. “As I sit on the plane to come back to India, I have a mix of emotions running through my heart. I feel sad leaving a fantastic group of people behind who were my friends and family for the past year during this mission. I am also excited about meeting all my friends, family and everyone in the country for the first time post mission. I guess this is what life is — everything all at once,” he wrote.

Acknowledges support and inspiration

The astronaut thanked everyone for the love and support he received throughout his journey. He also recalled the words of his commander Peggy Whitson, saying, “Goodbyes are hard, but we need to keep moving in life. As my commander Peggy Whitson fondly says, ‘The only constant in spaceflight is change’. I believe that applies to life as well.”

Shukla ended his note with a line from the song Yun Hi Chala Chal from the film Swades, reflecting his spirit of resilience.

Link to India’s space ambitions

Shukla’s return comes at a crucial time as India advances its space programme. Prime Minister Narendra Modi had earlier mentioned that the astronaut would soon return and that he was tasked with documenting his training and ISS stay. This record will serve as a valuable reference for Gaganyaan, India’s first human spaceflight mission.

Over the past year, Shukla trained extensively at NASA, Axiom, and SpaceX facilities. His flight to the ISS as part of the Axiom 4 mission marked a milestone in India’s preparations for future human space exploration.

The Gaganyaan project aims to send Indian astronauts into orbit aboard an indigenous rocket. The government has also outlined plans for a Bharatiya Antariksh Station by 2035 and a crewed mission to the moon by 2040.

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Shubhanshu Shukla becomes second Indian in space, lifts off for ISS aboard Axiom-4 mission

Group Captain Shubhanshu Shukla becomes the second Indian astronaut to travel to space after four decades, aboard the Axiom-4 mission to the International Space Station.

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Group Captain Shubhanshu Shukla of the Indian Air Force has etched his name in history as the second Indian astronaut to travel to space. Launching aboard the SpaceX Crew Dragon on the Axiom-4 mission, Shukla began his journey from NASA’s Kennedy Space Center in Florida, from the very launchpad that propelled Neil Armstrong’s Apollo 11 moon mission in 1969.

Four decades after Wing Commander Rakesh Sharma became the first Indian to journey into space in 1984, Shukla’s mission marks a monumental milestone for India’s space ambitions. Speaking ahead of the mission, Shukla expressed the emotional weight of the moment, saying, “I carry with me not just instruments and equipment, but the hopes and dreams of a billion hearts.”

A multinational crew on a scientific journey

Group Captain Shukla is joined by Commander Peggy Whitson from the US, Slawosz Uznanski-Wisniewski from Poland, and Tibor Kapu from Hungary. The four-member crew is on a mission to the International Space Station (ISS), where they are scheduled to arrive after a 28-hour journey and dock around 4:30 pm tomorrow.

The fortnight-long mission includes the execution of 60 scientific experiments, with seven of them designed by Indian researchers. Shukla is also expected to engage in an interaction with a VIP from space during the mission, adding a special human touch to this scientific voyage.

A mission delayed, but not denied

The Axiom-4 launch had faced multiple delays due to unfavorable weather and technical complications. June 25 finally saw the successful launch, marking NASA’s sixth official date announcement for the mission.

Before lift-off, Shukla shared a heartfelt message with his family: “Just wait for me, I’m coming.” The Indian pilot had been under quarantine for over a month in preparation, ensuring he was in optimal health for the journey.

As the spacecraft orbits Earth en route to the ISS, India watches with pride and anticipation, inspired once again by the courage of its space pioneers.

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