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China clones 5 gene-edited monkeys to aid disorder research

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[vc_row][vc_column][vc_column_text]On Thursday, Chinese scientists announced that they had cloned five monkeys from a single animal that was genetically engineered to have a sleep disorder, saying it could aid research into human psychological problems.

The claim, detailed in two reports published in a Chinese science journal, is the latest in a series of biomedical advances in the country, some of which have fuelled medical ethics debates.

Macaques are chiefly Asian monkeys typically having a sturdy build and including some short-tailed or tailless forms. The gene-edited macaque had circadian rhythm disorders associated with depression, diabetic, cancer and Alzheimer’s disease.

It is the first time multiple monkeys have been cloned from a gene-edited monkey for biomedical research, IANS quoted a Xinhua news agency report.

Poo Muming, the director of the neuroscience institute and the study’s co-author, told state media that the research team would seek to clone more monkeys with different brain disorders in hopes that future experiments on them could yield new drugs or treatment.

The cloned monkeys, closer to humans in terms of activity routines, brain structure and metabolic rate, make better models for research on disease pathogenesis and potential therapeutic treatments, according to the team from Institute of Neuroscience of Chinese Academy of Sciences in Shanghai.

To create an ideal donor monkey, the researchers knocked out BMAL1, a core circadian regulatory transcription factor, using gene editing at the embryo stage.

They selected one of the gene-edited monkeys with the most severe disease phenotypes as the donor.

The fibroblasts (the main connective tissue cells present in the body) of the donor were then used to clone five monkeys by somatic cell nuclear transfer, the same method used to generate Zhong Zhong and Hua Hua, the first cloned monkeys born in China at the end of 2017, the report published in the National Science Review journal revealed.

Different from Zhong Zhong and Hua Hua, generated by using fibroblasts from an aborted foetus, the new clones were made using a gene-edited young adult male monkey.

“It shows that besides using foetus, batch cloning of gene-edited male monkeys with diseases is also feasible,” Qiang Sun from the institute, was quoted as saying.

Sun stated the research programme was reviewed and supervised by the institute’s ethic committee in accordance with international ethical standards of animal research, the IANS report said.

In the future, the team plans would focus on cloning monkey models with different brain diseases.

Besides being used to study human brain diseases, the models will be used to test medicine effectiveness, which can help reduce the number of animal models used in experiments and lower the cost of medicine development, the report said.

(Inputs taken from media reports)[/vc_column_text][/vc_column][/vc_row]

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Kamala Harris vs Donald Trump: Voting begins in United States

Over 82 million Americans have opted for early voting to cast their ballots for Donald Trump or Kamala Harris.

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Kamala Harris vs Donald Trump: Voting begins in United States

The Voting for the 2024 US presidential election has begun in the eastern time zone in America. Following months of intense campaigning by Democratic nominee Kamala Harris and her Republican challenger Donald Trump, Americans will vote to choose their next president.

Reportedly, the first ballots were cast in the minutes after midnight (US time) in a tiny New Hampshire township along the US-Canada border. Over 82 million Americans have opted for early voting to cast their ballots for Donald Trump or Kamala Harris. Several pollsters have predicted a neck-and-neck contest, which brings the focus on the swing states to decide the fate of the presidential election.

Notably, in the United States, most states have a very clear preference for either the Republican or Democratic candidate. With this, only seven key swing states namely Michigan, Pennsylvania, Wisconsin, Arizona, Georgia, Nevada and North Carolina will decide the result. Winning the majority of these aforesaid swing states is often essential for candidates aiming to secure the 270 electoral votes needed to win the presidency.

In this election, Pennsylvania has emerged as the biggest prize between the two candidates. With the most electoral votes (19) than any other battleground state, Pennsylvania could possibly determine whether Donald Trump or Kamala Harris clinches the White House.

On the last day of campaigning, Republican nominee Trump and Democratic nominee Harris criss-crossed key battleground states and delivered closing remarks. Former President Donald Trump, who is seeking a return to power, held rallies in North Carolina, Pennsylvania and Michigan while Vice President Kamala Harris addressed supporters in Philadelphia and Pittsburgh in Pennsylvania.

Earlier in 2016, Donald Trump managed to make inroads in Michigan, Pennsylvania and Wisconsin, the three Great Lakes states that make up the blue wall or a Democratic stronghold. Nonetheless, in the 2020 US Election, US President Joe Biden wrested the states back to the Democratic camp.

Notably, to win the presidency, a candidate needs a majority of electoral votes of 270 out of 538.

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Amid India-Canada diplomatic tensions, Justin Trudeau shares video of his Diwali celebrations

This comes a day after India expressed its concern over the reports of cancelled Diwali celebrations in Canada.

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Amid the ongoing diplomatic tensions between Canada and India over the killing of Khalistani terrorist Hardeep Singh Nijjar, Canadian Prime Minister Justin Trudeau on Sunday shared a video of his Diwali celebration on social media platform X.

Sharing a 44-second video of his Diwali celebrations on social media, the Canadian Prime Minister wrote, “Happy Diwali! So many special moments shared celebrating with the community this week.”

This comes a day after India expressed its concern over the reports of cancelled Diwali celebrations in Canada.

The Ministry of External Affairs spokesperson Randhir Jaiswal on Saturday, while addressing the media over Canada’s serious allegation against Union Home Minister Amit Shah’s involvement in the killing of Khalistani terrorist Nijjar, said it was unfortunate that the prevailing atmosphere in Canada has reached high levels of intolerance and extremism.

In the video, Prime Minister Trudeau showed off some colorful religious threads on his wrists, explaining that he received them during visits to three Hindu temples in Canada recently. He called them symbols of “good luck” and “protection,” adding with a smile, “I’m not taking them off until they fall off”.

Trudeau was also seen interacting warmly with the community, celebrating the festival, and enjoying delicious Indian sweets like jalebis, which he jokingly said he would “save for the team.”

On November 1, Trudeau posted on X, “Happy Diwali! Today, Hindu, Sikh, Buddhist, and Jain families will celebrate the triumph of light over darkness with festivities, candles, diyas, and fireworks. Wishing you all joy and prosperity during this special time.”

Addressing a press conference in Delhi, Jaiswal said India condemns the recent allegations made by the Canadian government against Shah that he was purportedly involved in the killing of Nijjar and called it “absurd and baseless”.

Jaiswal also said that India had summoned the Canadian High Commissioner on Friday to protest in the strongest terms for the references made to the Union Home Minister of India before the Committee by Canada’s Deputy Foreign Affairs Minister David Morrison.

On Tuesday, Morrison claimed that Shah orchestrated a campaign of violence, intimidation, and intelligence-gathering aimed at Sikh separatists on Canadian soil. He informed members of Canada’s national security committee in Parliament that he had confirmed Shah’s name to The Washington Post, which was the first to report the allegations. However, Morrison did not provide details on how Canada became aware of Shah’s alleged involvement.

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India, China complete disengagement in Depsang, Demchok at LAC after 4 years standoff

The Indian Army said that coordinated patrolling will start soon by both sides, and the ground commanders will continue to hold talks.

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India, China complete disengagement in Depsang, Demchok at LAC after 4 years standoff

In a significant development, India and China have completed the disengagement exercise in the Depsang and Demchok friction points at the Line of Actual Control (LAC) in eastern Ladakh. The troops of both the countries are now verifying the vacation of positions and removal of infrastructure.

Reportedly, the Indian Army said that coordinated patrolling will start soon by both sides, and the ground commanders will continue to hold talks. The two sides will exchange sweets for Diwali tomorrow.

Earlier, Foreign secretary Vikram Misri announced that New Delhi and Beijing reached an agreement to disengage in the remaining friction points at LAC in eastern Ladakh. After the agreement, the two countries began troops disengagement at the two friction points at Demchok and Depsang plains on October 23.

India-China relations worsened because of the Chinese troops’ aggression along the Line of Actual Control, the de facto border, in April 2020. It further deteriorated on June 15, 2020, after 20 Indian soldiers died in the line of duty thwarting the Chinese offensive in the Galwan Valley. New Delhi had said India’s bilateral relations with China will normalise only after the situation at the LAC returns to what it was before May 2020.

Reports said that the Indian Army and the Chinese People’s Liberation Army (PLA) have pulled back their forward-deployed troops and equipment from the two flashpoints, and have also dismantled temporary structures that had been built during the four-year-long standoff.

The Indian soldiers will resume their patrolling in areas that had been cut off because of the PLA’s presence. Nonetheless, the disengagement in Depsang and Demchok will not lead to the creation of buffer zones.

Both the countries had disengaged from Galwan Valley, Pangong Tso, Gogra (PP-17A) and Hot Springs (PP-15) areas and created buffer zones. Speaking to a newspaper publication, Lieutenant General Vinod Bhatia (retd), a former director general of military operations said that the disengagement at Depsang and Demchok will facilitate patrolling by both sides in a coordinated manner, and in the agreed upon frequency and strength of the patrolling parties.

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