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China clones 5 gene-edited monkeys to aid disorder research

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[vc_row][vc_column][vc_column_text]On Thursday, Chinese scientists announced that they had cloned five monkeys from a single animal that was genetically engineered to have a sleep disorder, saying it could aid research into human psychological problems.

The claim, detailed in two reports published in a Chinese science journal, is the latest in a series of biomedical advances in the country, some of which have fuelled medical ethics debates.

Macaques are chiefly Asian monkeys typically having a sturdy build and including some short-tailed or tailless forms. The gene-edited macaque had circadian rhythm disorders associated with depression, diabetic, cancer and Alzheimer’s disease.

It is the first time multiple monkeys have been cloned from a gene-edited monkey for biomedical research, IANS quoted a Xinhua news agency report.

Poo Muming, the director of the neuroscience institute and the study’s co-author, told state media that the research team would seek to clone more monkeys with different brain disorders in hopes that future experiments on them could yield new drugs or treatment.

The cloned monkeys, closer to humans in terms of activity routines, brain structure and metabolic rate, make better models for research on disease pathogenesis and potential therapeutic treatments, according to the team from Institute of Neuroscience of Chinese Academy of Sciences in Shanghai.

To create an ideal donor monkey, the researchers knocked out BMAL1, a core circadian regulatory transcription factor, using gene editing at the embryo stage.

They selected one of the gene-edited monkeys with the most severe disease phenotypes as the donor.

The fibroblasts (the main connective tissue cells present in the body) of the donor were then used to clone five monkeys by somatic cell nuclear transfer, the same method used to generate Zhong Zhong and Hua Hua, the first cloned monkeys born in China at the end of 2017, the report published in the National Science Review journal revealed.

Different from Zhong Zhong and Hua Hua, generated by using fibroblasts from an aborted foetus, the new clones were made using a gene-edited young adult male monkey.

“It shows that besides using foetus, batch cloning of gene-edited male monkeys with diseases is also feasible,” Qiang Sun from the institute, was quoted as saying.

Sun stated the research programme was reviewed and supervised by the institute’s ethic committee in accordance with international ethical standards of animal research, the IANS report said.

In the future, the team plans would focus on cloning monkey models with different brain diseases.

Besides being used to study human brain diseases, the models will be used to test medicine effectiveness, which can help reduce the number of animal models used in experiments and lower the cost of medicine development, the report said.

(Inputs taken from media reports)[/vc_column_text][/vc_column][/vc_row]

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PM Modi and Netanyahu pledge deeper defence, trade ties during Israel visit

PM Narendra Modi and Benjamin Netanyahu pledged to deepen defence, trade and connectivity ties during Modi’s visit to Israel, with missile deals and IMEC discussions on the agenda.

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Prime Minister Narendra Modi and Israeli Prime Minister Benjamin Netanyahu have reaffirmed their commitment to strengthening defence, trade and security cooperation, marking a significant step forward in India-Israel relations during Mr Modi’s visit to Tel Aviv.

Addressing Israel’s parliament, the Knesset, Mr Modi described defence cooperation as an “important pillar” of the bilateral partnership and stressed the need for closer collaboration in an increasingly uncertain global environment.

“In today’s uncertain world, a strong defence partnership between trusted partners like India and Israel is of vital importance,” he said.

Defence deal likely on agenda

During the visit — Mr Modi’s first to Israel in nine years — discussions are expected to include a major order for Israeli-made missile systems. An official in New Delhi familiar with the matter indicated that details of the potential deal may not be publicly disclosed, as both governments are keen to keep the spotlight on broader strategic ties.

India’s Ministry of External Affairs has not commented on the reported missile purchase.

Israel has long been among India’s key arms suppliers. Over the years, the defence relationship has evolved into joint manufacturing projects, including drones and missile systems. Ahead of the visit, Israel’s Ambassador to India, Reuven Azar, said both sides are working towards a more comprehensive defence and security framework that could open doors for cooperation on more sensitive projects.

Focus on trade and investment

Trade and investment featured prominently in the leaders’ discussions. Mr Modi said both governments are committed to expanding bilateral trade, boosting investment flows and promoting joint infrastructure projects.

Israeli negotiators recently travelled to India to begin formal talks on a proposed free-trade agreement, building on terms agreed in November. Such a pact could provide Israel greater access to one of the world’s fastest-growing economies.

According to Israel’s Economy and Industry Ministry, India is Israel’s second-largest trading partner in Asia, with bilateral trade estimated at $5 billion in 2025, excluding defence transactions.

India is also the largest buyer of Israeli defence equipment, accounting for up to 34% of Israel’s total arms exports, according to data from the Stockholm International Peace Research Institute.

Regional security and Gaza ceasefire

The visit comes amid shifting regional alliances and ongoing security challenges. Referring to last year’s ceasefire in Gaza, Mr Modi said the truce created an opportunity for closer cooperation.

He also welcomed the US-brokered peace plan for Gaza, later endorsed by the United Nations, saying it holds the promise of a just and durable peace, including progress on the Palestine issue. However, uncertainty remains over the future of the truce with Hamas, with key governance and security questions yet to be resolved.

Strategic observers note that both leaders see their countries as operating in complex neighbourhoods marked by security threats and geopolitical shifts.

Connectivity push through IMEC

Connectivity initiatives also featured in the discussions. Mr Netanyahu told the Knesset that India and Israel are working on developing a maritime and land corridor linking India to Israel’s port of Haifa and onward to Europe.

The plan builds on the India-Middle East-Europe Economic Corridor initiative unveiled in September 2023. Although the outbreak of the Israel-Hamas conflict soon after raised concerns about the project’s future, Israeli officials have indicated that the corridor remains viable.

Haifa port, partly acquired by India’s Adani Group, is expected to play a key role as the Mediterranean endpoint of the corridor.

As India and Israel seek to reinforce strategic, economic and security ties, the visit underlines the growing convergence between New Delhi and Tel Aviv in defence, trade and regional connectivity.

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Canada softens stance on alleged Indian interference ahead of PM Carney’s India visit

Canada appears to ease its earlier allegations of Indian interference as PM Mark Carney heads to India to strengthen trade and strategic ties.

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Canada appears to be easing its earlier allegations of Indian interference as Prime Minister Mark Carney prepares for a key visit to India aimed at rebuilding commercial and diplomatic ties.

Senior officials in Ottawa indicated that the Canadian government maintains “mature and robust discussions” with the Government of India on concerns related to foreign interference. They also emphasised that Canada has strong safeguards in place to protect its democratic institutions.

According to officials quoted by media, the Prime Minister would likely not be travelling to India if Ottawa believed New Delhi was actively interfering in Canada’s democratic processes. The remarks suggest a noticeable shift from the strong accusations levelled last year.

Officials said there has been sustained engagement with the government of Narendra Modi at multiple levels, including senior officials, ministers and leadership-level interactions. They expressed confidence that the discussions provide a foundation for further constructive dialogue.

At the same time, a senior official reiterated that Canada maintains “no tolerance” for foreign interference in its domestic affairs.

From allegations to engagement

The recent comments contrast with statements made last June by the Canadian Security Intelligence Service (CSIS), which accused India of being among the primary actors involved in foreign interference and espionage activities in Canada.

CSIS had also described alleged links between Indian authorities and the 2023 killing of Hardeep Singh Nijjar in Vancouver as a “significant escalation” in India’s actions against the Khalistan movement.

India firmly rejected those accusations. The dispute triggered a diplomatic standoff, with both countries expelling senior diplomats from Ottawa and New Delhi in a tit-for-tat move.

Carney’s push to rebuild ties

Prime Minister Carney’s visit to India is being positioned as part of a broader Indo-Pacific outreach and a more pragmatic foreign policy approach. His trip will begin in Mumbai before he heads to New Delhi for talks with Prime Minister Modi.

The visit comes as both nations seek to stabilise relations that deteriorated sharply following Canada’s allegations over Nijjar’s killing — claims that New Delhi strongly denied.

Carney’s office has said discussions will centre on expanding cooperation in trade, energy, technology, artificial intelligence, talent mobility, culture and defence.

Growing trade partnership

India is currently Canada’s seventh-largest trading partner in goods and services. Annual bilateral trade exceeds $21 billion, according to Canadian government data.

The two sides had previously agreed to resume negotiations on a proposed free-trade agreement, targeting bilateral trade of $50 billion by 2030.

More than 600 Canadian companies operate in India across sectors such as information technology, banking, health sciences and financial services. Key Indian exports to Canada include pharmaceuticals, gems and jewellery, precious stones and seafood.

Diplomatic ties show signs of recovery

Canada hosts approximately 2.8 million people of Indian origin. Nearly 400,000 Indian students are enrolled in Canadian universities, making them the largest group of international students in the country.

Canada is also home to the largest Sikh population outside India, including some fringe separatist elements advocating for Khalistan.

Relations between the two countries began to improve after Carney assumed office in March 2025, with envoys restored and diplomatic engagement gradually resuming.

The upcoming visit is being viewed as a significant step toward stabilising ties and advancing economic cooperation amid shifting global trade dynamics and uncertainties linked to policies under US President Donald Trump.

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PM Modi reaffirms support for Israel, recalls 26/11 victims in Knesset address

Addressing Israel’s parliament, PM Narendra Modi reaffirmed India’s support for Israel, condemned terrorism, and recalled the 26/11 Mumbai attacks.

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Prime Minister Narendra Modi on Wednesday addressed the Knesset, expressing solidarity with Israel and condemning terrorism, while highlighting the growing partnership between the two nations.

Calling it a rare honour, Mr Modi said he brought greetings from 1.4 billion Indians and described his address as a symbol of the warmth between the two democracies.

Condolences over October 7 attack

The Prime Minister conveyed condolences for the lives lost in the October 7 attack by Hamas. He said India shares Israel’s grief and stands firmly with the country “with full conviction in this moment and beyond”.

“Nothing can justify terrorism,” Mr Modi said, adding that India too has suffered from terror attacks for decades. He recalled the 26/11 Mumbai attacks and the innocent lives lost, including Israeli citizens, and reiterated India’s policy of zero tolerance towards terrorism without double standards.

Reference to Abraham Accords and regional hope

Referring to the Abraham Accords, Mr Modi said India had applauded the vision and courage shown at the time. While noting that the regional situation has since become more challenging, he stressed the importance of sustaining hope for peace.

Historic ties and expanding partnership

The Prime Minister said he was the first Indian Prime Minister to visit Israel nine years ago and expressed happiness at returning. He also noted that he shares his birth date — September 17, 1950 — with the day India formally recognised Israel.

Recalling his earlier visit to Israel as Gujarat Chief Minister in 2006 and his 2017 trip as Prime Minister, Mr Modi said bilateral ties were elevated to a Strategic Partnership during the latter visit. Since then, he added, engagement has broadened across sectors.

He pointed to cooperation in innovation, mentioning the inauguration of the iCreate Technology Business Incubator in 2018 with then Prime Minister Benjamin Netanyahu. The incubator, he said, has since supported nearly 900 start-ups.

Shared civilisational values

Mr Modi said Jewish communities have lived in India without fear of persecution and have preserved their faith while participating fully in society. He described this as a matter of pride.

Highlighting philosophical parallels, he referred to the Israeli concept of “Tikkun Olam”, meaning healing the world, and India’s belief in “Vasudhaiva Kutumbakam”, which sees the world as one family. Both traditions, he said, call for compassion and moral courage beyond immediate boundaries.

He also acknowledged the contribution of Indian caregivers and skilled workers in Israel, noting their courage and dedication, including during the October 7 crisis.

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