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China clones 5 gene-edited monkeys to aid disorder research

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[vc_row][vc_column][vc_column_text]On Thursday, Chinese scientists announced that they had cloned five monkeys from a single animal that was genetically engineered to have a sleep disorder, saying it could aid research into human psychological problems.

The claim, detailed in two reports published in a Chinese science journal, is the latest in a series of biomedical advances in the country, some of which have fuelled medical ethics debates.

Macaques are chiefly Asian monkeys typically having a sturdy build and including some short-tailed or tailless forms. The gene-edited macaque had circadian rhythm disorders associated with depression, diabetic, cancer and Alzheimer’s disease.

It is the first time multiple monkeys have been cloned from a gene-edited monkey for biomedical research, IANS quoted a Xinhua news agency report.

Poo Muming, the director of the neuroscience institute and the study’s co-author, told state media that the research team would seek to clone more monkeys with different brain disorders in hopes that future experiments on them could yield new drugs or treatment.

The cloned monkeys, closer to humans in terms of activity routines, brain structure and metabolic rate, make better models for research on disease pathogenesis and potential therapeutic treatments, according to the team from Institute of Neuroscience of Chinese Academy of Sciences in Shanghai.

To create an ideal donor monkey, the researchers knocked out BMAL1, a core circadian regulatory transcription factor, using gene editing at the embryo stage.

They selected one of the gene-edited monkeys with the most severe disease phenotypes as the donor.

The fibroblasts (the main connective tissue cells present in the body) of the donor were then used to clone five monkeys by somatic cell nuclear transfer, the same method used to generate Zhong Zhong and Hua Hua, the first cloned monkeys born in China at the end of 2017, the report published in the National Science Review journal revealed.

Different from Zhong Zhong and Hua Hua, generated by using fibroblasts from an aborted foetus, the new clones were made using a gene-edited young adult male monkey.

“It shows that besides using foetus, batch cloning of gene-edited male monkeys with diseases is also feasible,” Qiang Sun from the institute, was quoted as saying.

Sun stated the research programme was reviewed and supervised by the institute’s ethic committee in accordance with international ethical standards of animal research, the IANS report said.

In the future, the team plans would focus on cloning monkey models with different brain diseases.

Besides being used to study human brain diseases, the models will be used to test medicine effectiveness, which can help reduce the number of animal models used in experiments and lower the cost of medicine development, the report said.

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Asim Munir appointed Pakistan’s first Chief of Defence Forces, to serve 5-year term

Field Marshal Asim Munir has been appointed Pakistan’s first Chief of Defence Forces, consolidating top military authority under a new constitutional amendment.

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Pakistan has named Field Marshal Syed Asim Munir as its first Chief of Defence Forces (CDF), marking a major restructuring in the country’s military command. The appointment was approved by President Asif Ali Zardari following a formal recommendation from Prime Minister Shehbaz Sharif.

Munir to hold dual charge as COAS and CDF

According to the President’s office, Munir will serve concurrently as Chief of the Army Staff (COAS) and Chief of Defence Forces for a five-year tenure. The creation of the CDF role — introduced under the 27th Constitutional Amendment — aims to centralise top-level military authority.

This decision comes after days of speculation due to delays in issuing the official notification, which was originally expected on November 29, the day Munir’s previous three-year term as army chief ended.

Former Indian security official Tilak Devasher had earlier commented to media that the Prime Minister appeared to be avoiding issuing the notification, leading to confusion within Pakistan’s military command structure.

Zardari also approves extension for Air Chief

Alongside Munir’s elevation, President Zardari approved a two-year service extension for Air Chief Marshal Zaheer Ahmad Babar Sidhu, effective from March 2026. The President extended his best wishes to both officers.

Munir, promoted to Field Marshal earlier this year, becomes only the second military officer in Pakistan’s history to hold this rank — the first being Gen. Ayub Khan.

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Imran Khan accuses Asim Munir of mental torture, says sister after rare jail meeting

Imran Khan has alleged “mental torture” inside Adiala Jail, according to his sister who met him after weeks of blocked access. The family claims authorities are withholding information about his condition.

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Former Pakistan Prime Minister Imran Khan has alleged that he is being “mentally tortured” in prison and held General Asim Munir responsible for his continued isolation, according to his sister Dr Uzma Khanum, who met him inside Rawalpindi’s Adiala Jail for 20 minutes.

Sister says Khan “angry” over isolation

Dr Khanum told reporters that her brother is allowed out of his cell only briefly and has no means of communication with the outside world. She said Khan expressed anger over the conditions in which he is being held, stating he remains confined all day with no access to his family or party members.

She also said Imran Khan directly blamed General Asim Munir — now seen as Pakistan’s most powerful authority, having consolidated military control and secured lifetime immunity for top officials — for the treatment he is receiving in custody.

Meeting follows weeks of denied access

The rare meeting came after weeks of barred family visits, which fuelled speculation about Khan’s health. His sisters earlier claimed they were assaulted when they sought permission to meet him, while his sons publicly alleged that jail authorities were concealing “something irreversible” about his condition.

One of his sons, Kasim Khan, told media that despite a court order for weekly family meetings, they had no direct or verified contact.

Family members also said prison authorities repeatedly refused entry to Imran Khan’s personal doctor.

Rumours and protests intensify

Before Tuesday’s meeting, neither his relatives nor his Pakistan Tehreek-e-Insaf colleagues had seen him for over 25 days, triggering widespread rumours of his death — speculation that officials did not counter with proof of life even as pressure mounted on Prime Minister Shehbaz Sharif’s government.

PTI’s Senator Khurram Zeeshan claimed Khan was being kept in isolation to force him into leaving Pakistan and accused authorities of withholding photos or videos due to fears over his influence.

The situation has sparked protests across Islamabad and Rawalpindi, including demonstrations outside the Islamabad High Court.

In jail since August 2023

Imran Khan, the 72-year-old former cricketer and World Cup-winning captain, has been incarcerated since August 2023. Rumours about his wellbeing first circulated from social media accounts in Afghanistan, at a time when both countries have been locked in military tensions over a border dispute.

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Trump pledges permanent pause on migration from Third World countries in Thanksgiving message

US President Donald Trump declared that migration from all Third World countries will be permanently paused, criticising current immigration policies and announcing measures to remove non-citizens who he says do not benefit the US.

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US President Donald Trump has announced that he will “permanently pause migration from all Third World countries”, asserting that the move is necessary for the United States to “recover” and “heal”. His remarks were delivered in a Thanksgiving post, where he sharply criticised the Biden administration’s immigration policies and outlined sweeping measures aimed at restricting migration and removing non-citizens who, he says, do not contribute to the country.

Trump said he intends to reverse what he described as “illegal admissions”, end federal benefits for non-citizens, and strip citizenship from migrants who pose security concerns. He also reiterated plans to deport individuals he considers a “public charge” or “non-compatible with Western Civilization”.

The statement came shortly after two members of the National Guard were shot near the White House, an attack Trump called an “act of terror”.

One National Guard member dies after Washington shooting

Trump confirmed that Specialist Sarah Beckstrom, 20, one of the two West Virginia National Guard soldiers shot near Farragut West Metro station on Wednesday, died of her injuries. The ambush occurred while Trump was in Florida.

The alleged shooter was identified as Rahmanullah Lakanwal, a 29-year-old Afghan national who entered the US in September 2021, according to enforcement officials.

‘Reverse migration’ needed, says Trump

In his post, Trump said his actions aim to significantly reduce “illegal and disruptive populations”, adding that only “reverse migration” can address the current situation. He accused the Biden administration of admitting migrants through an “unauthorized and illegal” approval process.

Concluding his message, he wished Americans a Happy Thanksgiving but added that those who “hate, steal, murder, and destroy” would “not be here for long”.

Attacks on foreign populations and Minnesota officials

Trump also targeted Somali refugees in Minnesota, alleging that gangs from the community are creating fear on the streets. He accused the Minnesota Governor of failing to address the situation due to “fear or incompetence”.

He further criticised Ilhan Omar, accusing her of complaining about the US despite her origins in a “crime ridden” nation.

Comments on America’s foreign-born population

Citing Census estimates, Trump claimed that the US foreign-born population stood at 53 million, alleging that “most are on welfare” or come from “failed nations” or criminal backgrounds. He said American citizens continue to support this population despite personal discomfort.

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