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Indian-made Gene therapy shows 73% response rate in blood cancer trials

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cancer gene therapy

An indigenously developed gene therapy for specific blood cancers has demonstrated a 73% response rate in clinical trials, offering new hope for patients in India. The findings, published in The Lancet Haematology, highlight the success of CAR T-cell therapy, which modifies a patient’s immune cells to combat cancer.

A breakthrough in cancer treatment

The therapy was developed through a collaboration between the Indian Institute of Technology-Bombay (IIT-B) and Tata Memorial Hospital, Mumbai. It has been designed to treat patients with relapsed or refractory B-cell malignancies, including leukemia and lymphoma, which often have poor outcomes due to limited treatment options.

Speaking on the impact of this therapy, Rahul Purwar, lead author and IIT-B professor, stated,

“The clinical trials of India’s first gene therapy for cancer offer hopes of another chance to live among these patients, that there is one more drug that doctors can try.”

Affordable alternative to global therapies

Unlike CAR T-cell therapies in developed nations, which cost between $373,000 to $475,000, the India-made injection ‘talicabtagene autoleucel’ is available for $30,000—making it significantly more affordable.

Developed over 11 years, the therapy was tested in two trial phases:

  • Phase 1: Included 14 patients (18+ years) with B-cell lymphoma.
  • Phase 2: Expanded to 50 patients (15+ years) with B-cell leukemia or lymphoma.

Among the 51 patients analyzed, the overall response rate was 73%, with two treatment-related deaths. Common side effects included neutropenia (low white blood cell count), thrombocytopenia (low platelet count), and anemia.

Future scope and clinical advancements

Dr. Hasmukh Jain, a medical oncology professor at Tata Memorial Hospital, emphasized the long-term benefits of CAR T-cells in preventing cancer relapse. He noted that new trials are underway to test the therapy in earlier settings and in combination with other immunotherapies at Tata Memorial Centre.

India News

LPG Aadhaar authentication mandatory for subsidy from October 1

Biometric Aadhaar authentication will be required for subsidised domestic LPG refills from October 1. Here is what changes for consumers who have and have not completed the process.

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LPG cylinder

Biometric Aadhaar authentication will become a requirement for domestic LPG consumers seeking to book refills at the regulated retail selling price with applicable subsidy from October 1, 2026.

The government has said the measure is aimed at ensuring that subsidised LPG reaches eligible households and at preventing the diversion of subsidised domestic cylinders for commercial and industrial use.

What changes from October 1

Consumers who have already completed biometric Aadhaar authentication will not have to repeat the process. Their LPG refills will continue as before.

For consumers who have not completed the authentication, refill booking at the regulated price with subsidy will be enabled after the authentication is completed.

As of September 19, 2026, 27.43 crore active domestic LPG consumers, or 89.9 per cent of the total, had completed biometric Aadhaar authentication, according to the Petroleum and Natural Gas Ministry.

How to complete Aadhaar authentication

Consumers who have not yet completed the process can do so through several channels.

Authentication can be completed during LPG delivery, at the distributor’s showroom or through the mobile applications of the three state-owned oil marketing companies.

Indane customers can use IndianOil ONE, Bharatgas customers can use HelloBPCL, while HP Gas customers can use HP PAY.

What if consumers do not complete authentication

The government has clarified that consumers who are unwilling or unable to complete biometric Aadhaar authentication can still receive LPG.

However, they will have to register their choice through the available digital channels of their oil marketing company, such as its consumer portal, mobile app, WhatsApp chatbot or IVRS.

Such consumers will be supplied LPG at the applicable market price without subsidy, in 5-kg or 10-kg cylinders, subject to local availability.

Why the government is introducing the requirement

According to the Petroleum and Natural Gas Ministry, linking each LPG connection to an Aadhaar-authenticated consumer is intended to prevent diversion of subsidised domestic cylinders and remove duplicate or ineligible connections.

The government has also said the measure is intended to make subsidy delivery more targeted and transparent.

Authentication deadline and progress

Consumers were initially asked to complete biometric Aadhaar authentication by June 30, 2026. The deadline was subsequently extended several times, with September 14 being the final extended deadline mentioned by the ministry.

The nationwide authentication drive has been underway since October 2023. The government said more than 12 crore SMS and WhatsApp messages had been sent as part of the outreach campaign.

The government has urged consumers who have not yet completed the process to do so before October 1.

LPG Aadhaar authentication becomes mandatory for subsidised domestic LPG refills from October 1. Consumers who have already completed biometric authentication need not do it again. Those who haven’t can still get LPG, but at the applicable market price without subsidy.

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BJP hits back at opposition over EC row, says disagreement is democracy

The BJP has defended reported differences among Election Commissioners, saying internal deliberations are part of a healthy democratic process.

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The BJP has defended the Election Commission amid a political row over reported differences among Election Commissioners concerning decisions linked to the Special Intensive Revision (SIR) of electoral rolls.

BJP MP Sambit Patra said discussions and exchanges of views within the poll panel should be seen as part of the democratic process rather than as evidence of institutional dysfunction.

According to the BJP’s position, disagreement during official deliberations reflects the fact that members of an institution are able to put forward their views before decisions are taken.

BJP defends EC deliberations

Patra said that if the three Election Commissioners discuss and debate issues among themselves, such exchanges should not be characterised as dictatorship. He described such deliberations as a sign of a healthy democracy.

The BJP’s response came amid reports that Election Commissioners Sukhbir Singh Sandhu and Vivek Joshi had raised objections on multiple occasions over decisions and orders associated with the SIR exercise and electoral rolls.

The Election Commission has said that differences in views and observations are a normal part of deliberations within an institution. It has maintained that decisions, including those related to SIR, were taken unanimously.

Row centres on SIR process

The controversy comes against the backdrop of the ongoing political debate over the Special Intensive Revision of electoral rolls.

Opposition parties have raised concerns over the reported differences within the poll panel, while the BJP has sought to counter those arguments by pointing to the role of discussion and deliberation in institutional decision-making.

Patra also said the BJP’s understanding of the matter was based on media reports rather than access to the Election Commission’s internal documents. He said the documents, as reported, indicated that the SIR process was finalised after democratic deliberations and consensus.

What the Election Commission has said

The Election Commission has rejected the suggestion that the reported objections indicate a breakdown in its functioning.

It has maintained that differing opinions during deliberations are part of normal institutional functioning and that the decisions eventually taken by the commission were unanimous.

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IIT Bombay Professor Suryanarayana Doolla sent on leave amid student suicide row

IIT Bombay professor Suryanarayana Doolla has been sent on leave amid the ongoing student protests following Sahil Wakode’s death.

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IIT Bombay professor Suryanarayana Doolla has been sent on leave amid the ongoing controversy following the death of 20-year-old student Sahil Wakode, with protests on the campus seeking action against the professor.

Doolla, a faculty member in IIT Bombay’s Department of Energy Science and Engineering, had been involved in the examination incident concerning Wakode. The student was allegedly found using a mobile phone during a mid-semester examination and had uploaded the question paper to an AI platform to seek answers, according to the institute.

Why Suryanarayana Doolla is at the centre of the controversy

Doolla was the course instructor and examination invigilator during the examination and was involved in reporting the alleged examination malpractice to the institute’s authorities.

IIT Bombay has said Wakode was subsequently counselled by the instructor and the Head of Department and was assured that the examination incident would not adversely affect his academic career. The institute has also maintained that no disciplinary action had been initiated against the student before his death.

Wakode’s family, however, alleged harassment and caste-based discrimination. Mumbai Police registered a case based on the family’s complaint, with Doolla among those named. The allegations remain subject to investigation.

Student protests at IIT Bombay

Following Wakode’s death, students began protesting on the IIT Bombay campus and demanded action against Doolla.

IIT Bombay Director Professor Shireesh Kedare met the protesting students on September 20 and signed an 18-point charter of demands. The demands included action against Doolla.

Doolla was subsequently removed from the post of Dean Students Welfare amid the protests. The latest action comes as the controversy surrounding Wakode’s death and the allegations against the professor continue to be investigated.

Faculty members back Doolla

While students have demanded action against Doolla, IIT Bombay’s Faculty Forum has backed the professor, saying he was performing his duties as an invigilator and had followed the institute’s prescribed procedure after detecting the alleged examination malpractice.

The controversy involves the examination incident, allegations made by Wakode’s family and the police investigation into his death. The allegations against Doolla have not been established as facts and remain part of the ongoing investigation.

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