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Scientists look to mathematics to make cancer treatment more effective

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Cancer Treatment

[vc_row][vc_column][vc_column_text]By Monika Kundu Srivastava

Scientists at the Pune-based National Chemical Laboratory (NCL) of Council of Scientific and Industrial Research (CSIR) have developed a mathematical model that promises to deliver better protocols for cancer treatment.

The model has three main components — one for core tumour and other cells that subsequently get affected by cancer; the second for immune stimulators or boosters that help protect normal cells from getting affected; and the third for immune suppressors or dampeners that allow cancer to spread. The model describes most of the ways by which the three ‘actors’ could affect or influence each other.

It is expected to be of significance as treatment protocols could be developed based on accurate calculations, thus avoiding the preventable and uncomfortable side-effects of cancer treatment, researchers said.

A cancer tumour consists mainly of cancer stem cells (94.6%), followed by cancer cells (4.5%), resistant cancer cells (1%) and drug-resistant stem cells (0.001%). The stem cells, depending on the kind of stimulation received, are capable of changing into any type of cell and multiply rapidly. The spread of the disease can be limited significantly, if within 400 days of tumour detection cancer stem cells can be stopped from multiplying and resistant cancer cells stopped from changing into cancer stem cells and drug-resistant stem cells respectively.

After 400 days, when the cells multiply rapidly, it becomes difficult to treat. Many structural changes happen due to mutation, breakages and other factors, which can result in the cells becoming resistant to traditional drugs or radiation and treatment becomes ineffective.

Researchers tested two treatment protocols based on various interactions: one using only radiation and medication while the second included immunotherapy. They found that there was vast improvement in latter protocol in the form of a huge reduction in multiplication rate of tumour cells. This was because radiation had no effect on resistant stem cells, and chemotherapy impacted both stem and cancer resistant cells. Immunotherapy, on the other hand, was found to be beneficial both at early and later stages. In the early stage (till 400 days), it did not allow the number of resistant cells to increase and in later stages it did not allow the tumour to have its full effect due to an increase in the number of protective cells fighting cancer cells.

“The model can be used as a potential tool for the prediction of cancer prognosis and calculation of fold changes in the tumour subpopulations in response to a new treatment regimen. The study opens up new avenues for further research in cancer treatment,” researchers said.

Commenting on the new model, Dr. Radhika Nair, Ramanujan Faculty Fellow at the Rajiv Gandhi Centre for Biotechnology, Thiruvananthapuram, said it was a novel study and the model could be applied to most cancers.

Researchers at National Chemical Laboratory (NCL), Pune

Researchers at National Chemical Laboratory (NCL), Pune

“The mathematical basis can help predict optimal drug dosage and treatment cycles which can have a huge benefit in avoiding unnecessary side effects of treatment. The model can also tell us how much intra-tumor heterogeneity as well as drug resistant cell population evolves in response to a new treatment regimen, that is, how the cancer might progress,” Dr Nair said.However,she said, while researchers have verified the model with known experimental data, it is essential to prove its clinical applicability as patients may have a unique manifestation of the disease.

The scientists – PiyaliGanguli and Ram Rup Sarkar of Chemical Engineering and Process Development Division at NCL – have published findings of their research in journal, PLOS One. The work was funded by the Science and Engineering Research Board (SERB). (India Science Wire)[/vc_column_text][/vc_column][/vc_row]

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NASA astronauts Sunita Williams, Nick Hague step outside spacecraft after 7 months

Williams’ extensive experience continues to shine during these demanding missions, highlighting the resilience and skill required for space exploration.

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NASA astronauts Sunita Williams and Nick Hague stepped outside the International Space Station (ISS) today for a vital mission, marking Williams’ eighth spacewalk and Hague’s fourth. Their objective focused on essential repairs, showcasing their expertise and commitment to the job.

The spacewalk, designated US Spacewalk 91, took place on January 16, 2025. This was Williams’ first spacewalk in 12 years, while Hague added a fourth accomplishment to his impressive track record. Together, they initiated a six-and-a-half-hour operation aimed at repairing critical systems on the ISS.

Their tasks included maintaining equipment for the station’s orientation, upgrading the Neutron Star Interior Composition ExploreR (NICER) telescope, and replacing a reflector on a docking adapter, as well as preparing tools for future work on the ISS. Williams, an accomplished astronaut, expressed her enthusiasm as she exited the station by radioing, “I’m coming out,” signalling her return to spacewalking duties.

Williams and her fellow astronaut Butch Wilmore were initially scheduled to return in June 2024 after a week-long mission aboard Boeing’s Starliner, but technical issues with the spacecraft forced an extended stay. NASA has since rescheduled their return for March or April. Additionally, safety concerns related to SpaceX’s Crew-10 mission have further delayed their plans. Nevertheless, the astronauts have adjusted well to life aboard the ISS.

NASA’s Flight Director, Nicole McElroy, commended the crew for their thorough preparations for the spacewalks. “The crew has studied the tasks and is fully ready,” McElroy noted.

https://twitter.com/Space_Station/status/1879916338527002938

Williams will join Wilmore for another spacewalk next week, where they will focus on removing an antenna assembly and collecting surface samples to study microorganisms on the station’s exterior. They will also prepare a spare elbow joint for the Canadarm2 robotic arm. NASA emphasizes that these activities are crucial for the upkeep of the station, with each spacewalk anticipated to last around six and a half hours.

Williams’ extensive experience continues to shine during these demanding missions, highlighting the resilience and skill required for space exploration.

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ISRO successfully completes SpaDeX docking experiment, joins global elite in space technology

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ISRO SpaDeX mission demonstrating satellite docking for India’s space station

The Indian Space Research Organisation (ISRO) has successfully conducted the SpaDeX docking experiment, marking a significant advancement in India’s space capabilities. Early on Thursday, January 16, 2025, ISRO joined the ranks of the USA, Russia, and China by mastering the complex technology required for spacecraft docking in orbit.

Launched on December 30, 2024, by the PSLV C60, the two satellites involved in the experiment, SDX01 (Chaser) and SDX02 (Target), reached their designated positions and executed a flawless docking maneuver. This operation was closely monitored by the team at ISRO’s Mission Operations Complex (MOX) at the Telemetry, Tracking, and Command Network (ISTRAC).

Celebrating this achievement, ISRO shared on social media, “Docking Success Spacecraft docking successfully completed! A historic moment. India became the 4th country to achieve successful space docking. Congratulations to the entire team!”

Following the successful docking, ISRO has maintained control over the newly unified satellite structure and plans to conduct undocking and power transfer tests in the forthcoming days. This mission, beyond its immediate success, aims to lay the groundwork for more ambitious endeavors such as manned lunar missions, sample returns from the moon, and potentially an Indian Space Station.

The SpaDeX mission also serves as a demonstration of vital technologies like electrical power transfer between docked spacecraft, which will be crucial for future in-space robotic operations and composite spacecraft management post-undocking.

ISRO stated that the next steps involve validating the docking process through ground simulations and ensuring the mission’s objectives continue smoothly with subsequent experiments planned over the mission’s expected life span of up to two years.

This milestone not only demonstrates ISRO’s growing capabilities in space technology but also promises to bolster India’s position in future international space exploration initiatives.

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SpaDeX Mission: A key milestone in India’s path to the Bharatiya Antriksh Station

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ISRO SpaDeX mission demonstrating satellite docking for India’s space station

In a historic step towards establishing its own space station, the Indian Space Research Organisation (ISRO) launched the Space Docking Experiment (SpaDeX) from Sriharikota on December 30, 2024. This groundbreaking mission aims to demonstrate India’s capability to dock two satellites in orbit, a feat achieved so far only by the United States, Russia, and China.

The SpaDeX mission, executed aboard the reliable PSLV-C60 rocket, successfully deployed two spacecraft, SDX01 and SDX02, into a low-Earth orbit approximately 475 kilometers above Earth. Over the following days, these satellites, designated as the “Chaser” and the “Target,” will perform precise maneuvers for docking, undocking, and interlocking, with real-time control by ISRO scientists in Bengaluru.

A leap towards Bharatiya Antriksh Station

SpaDeX is integral to India’s ambitious space station project, the Bharatiya Antriksh Station, slated for completion by 2035. The mission marks a significant step in developing technologies for rendezvous and docking, essential for constructing and operating a space station.

Currently, only two space stations exist—the International Space Station (ISS), a collaboration between NASA, Roscosmos, and ESA, and China’s Tiangong Space Station. With Bharatiya Antriksh Station, India aspires to join this elite league.

Critical objectives of SpaDeX

The primary goals of SpaDeX include:

  1. Demonstrating docking technology to ensure seamless interlocking and pressure checks between spacecraft.
  2. Electric power transfer between docked spacecraft, paving the way for advanced in-space operations.
  3. Composite spacecraft control, enabling remote and automated management from mission control.
  4. Payload experiments post-undocking, ensuring optimal utilization of resources.

These advancements will also enhance the docking capability of India’s Reusable Launch Vehicle (RLV), akin to NASA’s space shuttles, for future missions.

Microgravity experiments with POEM-4

In tandem with SpaDeX, ISRO is conducting microgravity experiments using the PSLV’s fourth stage, termed POEM-4 (PSLV Orbital Experimental Module-4). This platform hosts 24 payloads, including a robotic arm to simulate debris capture—a crucial capability for future space station operations.

The microgravity experiments will benefit academia, startups, and ISRO’s own research centers, providing invaluable insights for extended-duration missions.

Inspiration from “Interstellar”

Docking in space is a complex maneuver, vividly dramatized in the sci-fi film Interstellar. Similar to the movie’s high-stakes scenario, ISRO’s mission involves the Chaser spacecraft approaching and interlocking with the Target while both orbit Earth at high speeds.

Pioneering India’s space future

The SpaDeX mission is not just a technological milestone but a testament to India’s growing prowess in space exploration. If successful, it will cement India’s position as a leader in cutting-edge space technology, bringing the nation closer to realizing its space station dream.

By leveraging such innovations, ISRO continues to push boundaries, inspiring the next generation of scientists and contributing to global advancements in space research.

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