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New study suggests kidney disease may be linked to pesticide exposure

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New study suggests kidney disease may be linked to pesticide exposure

By Bhavya Khullar

Joint study by University College of Medical Sciences and Guru Teg Bahadur Hospital shows Chronic Kidney Disease patients had higher levels of three pesticides

New Delhi, September 7 (India Science Wire): Patients with chronic kidney disease have higher amounts of organochlorine pesticides in their body, a Delhi-based study has indicated.

Doctors at the University College of Medical Sciences and Guru Teg Bahadur Hospital in Delhi studied 300 individuals aged 30-54 years, who visited kidney clinic between January 2014 and March 2015. Their blood samples were tested for presence of a range of organochlorine pesticides – alpha and beta endosulphan, DDT and DDE, dieldrin, Aldrin, and alpha, beta, and gamma HCH.

“We found that Chronic Kidney Disease (CKD) patients had higher levels of three pesticides, beta-endosuplhan, aldrin, and alpha-HCH in their blood as compared to healthy people”, Ashok Kumar Tripathi, who led the research, told the India Science Wire. This, he said, suggested a possible involvement of pesticides with abnormal kidney function.

It was found that the median levels of alpha-HCH, beta-endosulphan, and aldrin in healthy subjects were 0.7, 1.38, and 1.6 parts per billion respectively. In patients of chronic kidney disease, these levels were significantly higher -1.68, 2.38, and 2.15 parts per billion respectively. The results were published recently in journal Environmental Health and Preventive Medicine.

Although the mechanism of how pesticides affect kidney health is yet to be elucidated, researchers believe that accumulated amounts of pesticides may induce oxidative stress in the kidneys, which leads to CKD. In order to confirm the link, follow up studies with a larger group of people are required, said Dr Tripathi.

Still the study is significant because it finds high levels of pesticides in people living in an urban area like Delhi – who are not directly involved in agricultural activity or manufacture of pesticides – and who probably got exposed through environmental contamination, pointed out Catharina Wesseling, toxicologist at the Central American Institute for Studies on Toxic Substances, Universidad Nacional in Costa Rica. She was not involved in the Delhi study.

Dr Wesseling told India Science Wire that, “while this study does not establish that pesticides cause kidney disease, it is known that many pesticides are toxic for the kidneys. One can expect to find associations between (some) pesticides and kidney dysfunction”.

Organochlorine pesticides such as DDT and endosulfan are banned in many countries owing to their long persistence in the environment and adverse impacts on human health. Previous studies from El Salvador, Central America, Mexico, and Sri Lanka have indicated their possible involvement in development of CKD. Chronic Kidney Disease affects nearly 17 percent of the Indian population and is expected to rise with increasing cases of hypertension and diabetes.

The research team included Rishila Ghosh, Manushi Siddarth, Neeru Singh, Vipin Tyagi, Pawan Kumar Kare, Basu Dev Banerjee, Om Prakash Kalra, and Ashok Kumar Tripathi. This study was funded by the Department of Science and Technology (DST-SERB).

(This is an article from a syndicated feed provided by the Indian Science Wire)

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NASA astronauts Sunita Williams, Nick Hague step outside spacecraft after 7 months

Williams’ extensive experience continues to shine during these demanding missions, highlighting the resilience and skill required for space exploration.

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NASA astronauts Sunita Williams and Nick Hague stepped outside the International Space Station (ISS) today for a vital mission, marking Williams’ eighth spacewalk and Hague’s fourth. Their objective focused on essential repairs, showcasing their expertise and commitment to the job.

The spacewalk, designated US Spacewalk 91, took place on January 16, 2025. This was Williams’ first spacewalk in 12 years, while Hague added a fourth accomplishment to his impressive track record. Together, they initiated a six-and-a-half-hour operation aimed at repairing critical systems on the ISS.

Their tasks included maintaining equipment for the station’s orientation, upgrading the Neutron Star Interior Composition ExploreR (NICER) telescope, and replacing a reflector on a docking adapter, as well as preparing tools for future work on the ISS. Williams, an accomplished astronaut, expressed her enthusiasm as she exited the station by radioing, “I’m coming out,” signalling her return to spacewalking duties.

Williams and her fellow astronaut Butch Wilmore were initially scheduled to return in June 2024 after a week-long mission aboard Boeing’s Starliner, but technical issues with the spacecraft forced an extended stay. NASA has since rescheduled their return for March or April. Additionally, safety concerns related to SpaceX’s Crew-10 mission have further delayed their plans. Nevertheless, the astronauts have adjusted well to life aboard the ISS.

NASA’s Flight Director, Nicole McElroy, commended the crew for their thorough preparations for the spacewalks. “The crew has studied the tasks and is fully ready,” McElroy noted.

https://twitter.com/Space_Station/status/1879916338527002938

Williams will join Wilmore for another spacewalk next week, where they will focus on removing an antenna assembly and collecting surface samples to study microorganisms on the station’s exterior. They will also prepare a spare elbow joint for the Canadarm2 robotic arm. NASA emphasizes that these activities are crucial for the upkeep of the station, with each spacewalk anticipated to last around six and a half hours.

Williams’ extensive experience continues to shine during these demanding missions, highlighting the resilience and skill required for space exploration.

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ISRO successfully completes SpaDeX docking experiment, joins global elite in space technology

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ISRO SpaDeX mission demonstrating satellite docking for India’s space station

The Indian Space Research Organisation (ISRO) has successfully conducted the SpaDeX docking experiment, marking a significant advancement in India’s space capabilities. Early on Thursday, January 16, 2025, ISRO joined the ranks of the USA, Russia, and China by mastering the complex technology required for spacecraft docking in orbit.

Launched on December 30, 2024, by the PSLV C60, the two satellites involved in the experiment, SDX01 (Chaser) and SDX02 (Target), reached their designated positions and executed a flawless docking maneuver. This operation was closely monitored by the team at ISRO’s Mission Operations Complex (MOX) at the Telemetry, Tracking, and Command Network (ISTRAC).

Celebrating this achievement, ISRO shared on social media, “Docking Success Spacecraft docking successfully completed! A historic moment. India became the 4th country to achieve successful space docking. Congratulations to the entire team!”

Following the successful docking, ISRO has maintained control over the newly unified satellite structure and plans to conduct undocking and power transfer tests in the forthcoming days. This mission, beyond its immediate success, aims to lay the groundwork for more ambitious endeavors such as manned lunar missions, sample returns from the moon, and potentially an Indian Space Station.

The SpaDeX mission also serves as a demonstration of vital technologies like electrical power transfer between docked spacecraft, which will be crucial for future in-space robotic operations and composite spacecraft management post-undocking.

ISRO stated that the next steps involve validating the docking process through ground simulations and ensuring the mission’s objectives continue smoothly with subsequent experiments planned over the mission’s expected life span of up to two years.

This milestone not only demonstrates ISRO’s growing capabilities in space technology but also promises to bolster India’s position in future international space exploration initiatives.

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SpaDeX Mission: A key milestone in India’s path to the Bharatiya Antriksh Station

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ISRO SpaDeX mission demonstrating satellite docking for India’s space station

In a historic step towards establishing its own space station, the Indian Space Research Organisation (ISRO) launched the Space Docking Experiment (SpaDeX) from Sriharikota on December 30, 2024. This groundbreaking mission aims to demonstrate India’s capability to dock two satellites in orbit, a feat achieved so far only by the United States, Russia, and China.

The SpaDeX mission, executed aboard the reliable PSLV-C60 rocket, successfully deployed two spacecraft, SDX01 and SDX02, into a low-Earth orbit approximately 475 kilometers above Earth. Over the following days, these satellites, designated as the “Chaser” and the “Target,” will perform precise maneuvers for docking, undocking, and interlocking, with real-time control by ISRO scientists in Bengaluru.

A leap towards Bharatiya Antriksh Station

SpaDeX is integral to India’s ambitious space station project, the Bharatiya Antriksh Station, slated for completion by 2035. The mission marks a significant step in developing technologies for rendezvous and docking, essential for constructing and operating a space station.

Currently, only two space stations exist—the International Space Station (ISS), a collaboration between NASA, Roscosmos, and ESA, and China’s Tiangong Space Station. With Bharatiya Antriksh Station, India aspires to join this elite league.

Critical objectives of SpaDeX

The primary goals of SpaDeX include:

  1. Demonstrating docking technology to ensure seamless interlocking and pressure checks between spacecraft.
  2. Electric power transfer between docked spacecraft, paving the way for advanced in-space operations.
  3. Composite spacecraft control, enabling remote and automated management from mission control.
  4. Payload experiments post-undocking, ensuring optimal utilization of resources.

These advancements will also enhance the docking capability of India’s Reusable Launch Vehicle (RLV), akin to NASA’s space shuttles, for future missions.

Microgravity experiments with POEM-4

In tandem with SpaDeX, ISRO is conducting microgravity experiments using the PSLV’s fourth stage, termed POEM-4 (PSLV Orbital Experimental Module-4). This platform hosts 24 payloads, including a robotic arm to simulate debris capture—a crucial capability for future space station operations.

The microgravity experiments will benefit academia, startups, and ISRO’s own research centers, providing invaluable insights for extended-duration missions.

Inspiration from “Interstellar”

Docking in space is a complex maneuver, vividly dramatized in the sci-fi film Interstellar. Similar to the movie’s high-stakes scenario, ISRO’s mission involves the Chaser spacecraft approaching and interlocking with the Target while both orbit Earth at high speeds.

Pioneering India’s space future

The SpaDeX mission is not just a technological milestone but a testament to India’s growing prowess in space exploration. If successful, it will cement India’s position as a leader in cutting-edge space technology, bringing the nation closer to realizing its space station dream.

By leveraging such innovations, ISRO continues to push boundaries, inspiring the next generation of scientists and contributing to global advancements in space research.

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