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China clones 5 gene-edited monkeys to aid disorder research

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[vc_row][vc_column][vc_column_text]On Thursday, Chinese scientists announced that they had cloned five monkeys from a single animal that was genetically engineered to have a sleep disorder, saying it could aid research into human psychological problems.

The claim, detailed in two reports published in a Chinese science journal, is the latest in a series of biomedical advances in the country, some of which have fuelled medical ethics debates.

Macaques are chiefly Asian monkeys typically having a sturdy build and including some short-tailed or tailless forms. The gene-edited macaque had circadian rhythm disorders associated with depression, diabetic, cancer and Alzheimer’s disease.

It is the first time multiple monkeys have been cloned from a gene-edited monkey for biomedical research, IANS quoted a Xinhua news agency report.

Poo Muming, the director of the neuroscience institute and the study’s co-author, told state media that the research team would seek to clone more monkeys with different brain disorders in hopes that future experiments on them could yield new drugs or treatment.

The cloned monkeys, closer to humans in terms of activity routines, brain structure and metabolic rate, make better models for research on disease pathogenesis and potential therapeutic treatments, according to the team from Institute of Neuroscience of Chinese Academy of Sciences in Shanghai.

To create an ideal donor monkey, the researchers knocked out BMAL1, a core circadian regulatory transcription factor, using gene editing at the embryo stage.

They selected one of the gene-edited monkeys with the most severe disease phenotypes as the donor.

The fibroblasts (the main connective tissue cells present in the body) of the donor were then used to clone five monkeys by somatic cell nuclear transfer, the same method used to generate Zhong Zhong and Hua Hua, the first cloned monkeys born in China at the end of 2017, the report published in the National Science Review journal revealed.

Different from Zhong Zhong and Hua Hua, generated by using fibroblasts from an aborted foetus, the new clones were made using a gene-edited young adult male monkey.

“It shows that besides using foetus, batch cloning of gene-edited male monkeys with diseases is also feasible,” Qiang Sun from the institute, was quoted as saying.

Sun stated the research programme was reviewed and supervised by the institute’s ethic committee in accordance with international ethical standards of animal research, the IANS report said.

In the future, the team plans would focus on cloning monkey models with different brain diseases.

Besides being used to study human brain diseases, the models will be used to test medicine effectiveness, which can help reduce the number of animal models used in experiments and lower the cost of medicine development, the report said.

(Inputs taken from media reports)[/vc_column_text][/vc_column][/vc_row]

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Nvidia CEO Jensen Huang resigns amid affair scandal, Colette Kress takes over

Nvidia CEO Jensen Huang has resigned amid an affair-related controversy. The company’s CFO, Colette Kress, will serve as interim CEO while the board looks for a permanent successor.

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colette kress

Nvidia CEO Jensen Huang has resigned from his position, marking a major leadership change at the world’s leading artificial intelligence chipmaker. The company’s board has appointed Chief Financial Officer Colette Kress as interim CEO while it begins the process of finding a permanent successor.

The development comes amid controversy surrounding reports of Huang’s alleged extramarital relationships, including one involving a Chinese businesswoman suspected by US authorities of having links to espionage activities.

Huang’s departure comes after more than three decades at the helm of Nvidia, the company he co-founded in 1993. His leadership helped transform the business from a graphics chip manufacturer into a dominant supplier of processors powering the global artificial intelligence industry.

Colette Kress appointed interim Nvidia CEO

Following Huang’s resignation, Nvidia’s board appointed Colette Kress as interim chief executive officer.

Kress, who has served as Nvidia’s executive vice president and CFO since September 2013, will continue to hold the finance portfolio alongside her interim leadership responsibilities until a permanent successor is appointed.

Before joining Nvidia, she spent nearly 25 years working in finance roles at major technology companies, including Cisco and Microsoft.

The board has said it will consider both internal and external candidates as part of its search for a permanent CEO.

Nvidia has also appointed Harvey C. Jones as the company’s first-ever chairman of the board.

Affair controversy surrounding Jensen Huang

Huang’s resignation follows a series of reports about alleged extramarital relationships that have raised questions about his position at the company.

One of the controversies involves Alice Huang, a Chinese businesswoman whom US intelligence agencies reportedly suspect of involvement in facilitating shipments of Nvidia chips to Chinese companies.

Another report alleged that Huang had a relationship with Kimberly Powell, Nvidia’s vice president of healthcare, who reportedly worked under him.

Huang had earlier acknowledged being unfaithful to his wife in a message to Nvidia employees, taking responsibility for his actions and apologising to his family and colleagues.

The company’s board had also initiated an independent investigation into whether Huang had been targeted as part of a foreign intelligence operation.

Jensen Huang’s departure marks a major change for Nvidia

Huang co-founded Nvidia in 1993 alongside Curtis Priem and Chris Malachowsky. Under his leadership, the company evolved from a graphics processing unit manufacturer primarily associated with gaming into a central player in the global AI industry.

Nvidia’s processors have become critical to companies developing and operating artificial intelligence systems, making the company one of the most influential businesses in the technology sector.

His departure also comes at a crucial time for Nvidia, with investors closely watching the company’s leadership transition and its ability to maintain its position in the rapidly expanding AI market.

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India, Canada discuss trade pact to boost bilateral commerce

India and Canada discussed advancing negotiations on a proposed Comprehensive Economic Partnership Agreement aimed at expanding trade, investment and market access between the two countries.

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India and Canada discussed advancing negotiations on a proposed trade agreement as the two countries seek to strengthen their economic and commercial ties.

Commerce and Industry Minister Piyush Goyal met Canada’s Minister of International Trade Maninder Sidhu, who is leading a Canadian delegation to India. The discussions focused on advancing negotiations for the proposed India-Canada Comprehensive Economic Partnership Agreement (CEPA).

The proposed pact is aimed at creating greater market access and opening up new opportunities for trade and investment between the two countries.

India-Canada CEPA talks

Both sides discussed the importance of a balanced and mutually beneficial agreement that can make use of the complementary strengths of the two economies.

The discussions also focused on deepening commercial engagement and creating new opportunities for businesses in both countries.

Goyal said the two sides reaffirmed their commitment to taking the India-Canada economic partnership to a higher level, with CEPA serving as a catalyst for deeper commercial engagement.

India and Canada are working towards concluding the CEPA negotiations by the end of 2026.

India-Canada trade

The proposed CEPA is aimed at improving market access and creating opportunities across sectors while strengthening the broader economic relationship between India and Canada.

The agreement is expected to provide greater opportunities for businesses in both countries and support deeper trade and investment ties.

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White House put on temporary lockdown after car crashes into signpost

The White House was temporarily placed under lockdown after a car crashed into a signpost near Lafayette Square in Washington, DC. The driver was detained after a confrontation with security personnel.

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The White House was placed under a temporary lockdown on Monday after a car crashed into a signpost at Lafayette Square near the presidential residence in Washington, DC.

The incident triggered a security response in the area, with the US Secret Service directing members of the White House press corps to move indoors and remain there temporarily.

Driver detained after confrontation with security personnel

The driver was detained following a confrontation with Secret Service officers and National Guard personnel, according to reports.

Video footage showed a silver sedan on the paved area at the northern end of Lafayette Square after striking a signpost. Smoke was also seen coming from the vehicle.

Authorities had not immediately disclosed the driver’s identity or established what led to the crash.

White House security restrictions imposed

The security response prompted temporary restrictions around the White House. The incident occurred at Lafayette Square, which is directly across Pennsylvania Avenue from the presidential complex.

At around 10 am local time, Secret Service personnel instructed White House journalists to move indoors while security personnel dealt with the incident.

The White House was under the security restriction while President Donald Trump was at the premises, according to reports.

Motive behind crash remains unclear

It was not immediately known whether the crash was accidental or deliberate. Authorities had also not immediately confirmed whether anyone was injured.

The circumstances surrounding the incident, including the driver’s identity and possible motive, remained under investigation.

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