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China clones 5 gene-edited monkeys to aid disorder research

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[vc_row][vc_column][vc_column_text]On Thursday, Chinese scientists announced that they had cloned five monkeys from a single animal that was genetically engineered to have a sleep disorder, saying it could aid research into human psychological problems.

The claim, detailed in two reports published in a Chinese science journal, is the latest in a series of biomedical advances in the country, some of which have fuelled medical ethics debates.

Macaques are chiefly Asian monkeys typically having a sturdy build and including some short-tailed or tailless forms. The gene-edited macaque had circadian rhythm disorders associated with depression, diabetic, cancer and Alzheimer’s disease.

It is the first time multiple monkeys have been cloned from a gene-edited monkey for biomedical research, IANS quoted a Xinhua news agency report.

Poo Muming, the director of the neuroscience institute and the study’s co-author, told state media that the research team would seek to clone more monkeys with different brain disorders in hopes that future experiments on them could yield new drugs or treatment.

The cloned monkeys, closer to humans in terms of activity routines, brain structure and metabolic rate, make better models for research on disease pathogenesis and potential therapeutic treatments, according to the team from Institute of Neuroscience of Chinese Academy of Sciences in Shanghai.

To create an ideal donor monkey, the researchers knocked out BMAL1, a core circadian regulatory transcription factor, using gene editing at the embryo stage.

They selected one of the gene-edited monkeys with the most severe disease phenotypes as the donor.

The fibroblasts (the main connective tissue cells present in the body) of the donor were then used to clone five monkeys by somatic cell nuclear transfer, the same method used to generate Zhong Zhong and Hua Hua, the first cloned monkeys born in China at the end of 2017, the report published in the National Science Review journal revealed.

Different from Zhong Zhong and Hua Hua, generated by using fibroblasts from an aborted foetus, the new clones were made using a gene-edited young adult male monkey.

“It shows that besides using foetus, batch cloning of gene-edited male monkeys with diseases is also feasible,” Qiang Sun from the institute, was quoted as saying.

Sun stated the research programme was reviewed and supervised by the institute’s ethic committee in accordance with international ethical standards of animal research, the IANS report said.

In the future, the team plans would focus on cloning monkey models with different brain diseases.

Besides being used to study human brain diseases, the models will be used to test medicine effectiveness, which can help reduce the number of animal models used in experiments and lower the cost of medicine development, the report said.

(Inputs taken from media reports)[/vc_column_text][/vc_column][/vc_row]

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PM Modi, Xi Jinping among global leaders Donald Trump says he admires most

Donald Trump named Narendra Modi and Xi Jinping among the world leaders he admires most, praising Modi’s negotiating skills and describing Xi as “all business”.

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Donald Trump statement

US President Donald Trump has named Prime Minister Narendra Modi and Chinese President Xi Jinping among the world leaders he admires most, offering praise for both leaders during a recent interview.

Asked which global leaders he respects and admires, Trump pointed to Modi and Xi. He described the Indian Prime Minister as “a very tough cookie” and praised his negotiating abilities, while characterising the Chinese President as someone who is “all business.”

Speaking about Modi, Trump said the Indian leader is a strong negotiator who is difficult to outmanoeuvre in discussions.Trump’s remarks came shortly after his meeting with PM Modi on the sidelines of the G7 Summit in France. 

Trump also spoke positively about Xi Jinping, highlighting his focused approach to leadership. Despite differences between Washington and Beijing on several issues, Trump indicated that he maintains respect for Xi’s abilities and leadership style.

The comments reflect Trump’s emphasis on dealing directly with influential world leaders and his tendency to evaluate leaders based on their negotiating skills, leadership qualities and effectiveness on the global stage.

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Times Square shooting sparks panic in New York, one injured

A shooting in New York’s Times Square left one person injured and caused panic among tourists and commuters before police detained a suspect.

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A shooting in New York City’s Times Square caused panic among hundreds of people on Thursday after gunfire erupted in the crowded entertainment and tourist district. Authorities said one person was injured in the incident, while police quickly detained a suspect and began an investigation.

Videos shared on social media showed people running through the streets and seeking cover as the sound of gunshots echoed through the area. The incident unfolded in one of Manhattan’s busiest locations, which is usually packed with tourists, office workers and commuters.

According to officials, emergency responders reached the scene shortly after the shooting was reported. The injured person was taken to a nearby hospital for treatment. Authorities have not immediately released details about the victim’s condition.

Police officers already deployed in the area moved swiftly to secure the location and apprehend a suspect. Investigators are examining the circumstances that led to the shooting and are working to determine whether any other individuals were involved.

Initial reports suggested that the gunfire may have followed an altercation, though officials have not confirmed a motive. The investigation remains ongoing, and authorities are reviewing evidence and witness accounts from the scene.

The shooting drew attention because of its location in Times Square, one of New York City’s most visited landmarks. Despite the brief period of chaos, law enforcement officers were able to restore order and secure the area.

Officials have urged anyone with information about the incident to come forward as investigators continue to piece together the events that led to the shooting.

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US-Iran deal text released: Strait of Hormuz reopening, $300 billion fund and no-nuclear pledge among key provisions

The newly released US-Iran agreement includes provisions for reopening the Strait of Hormuz, launching a proposed $300 billion reconstruction fund and advancing negotiations on Iran’s nuclear programme.

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The memorandum of understanding sets out a roadmap for restoring maritime trade, advancing nuclear negotiations and supporting Iran’s economic recovery through a proposed reconstruction fund.

The United States has released the text of a memorandum of understanding (MoU) with Iran, laying out the framework for ending months of conflict and opening the door to broader negotiations on Tehran’s nuclear programme and economic future. The agreement includes commitments on reopening the Strait of Hormuz, a pledge from Iran not to pursue nuclear weapons, and the creation of a proposed $300 billion reconstruction and development fund.

According to the released text, Iran has agreed to ensure the restoration of commercial shipping through the Strait of Hormuz, one of the world’s most important energy transit routes. The US, in turn, has committed to lifting its naval blockade and refraining from imposing new sanctions during a 60-day negotiation period aimed at reaching a broader and more comprehensive agreement.

Hormuz reopening central to agreement

A major component of the deal focuses on restoring maritime traffic in the Persian Gulf and Gulf of Oman. The memorandum calls for the reopening of the Strait of Hormuz to safe commercial navigation, a move expected to ease concerns in global energy markets after months of disruption.

The agreement also outlines cooperation between both sides to reduce tensions in the region and maintain freedom of navigation through the strategic waterway.

Iran reiterates no-nuclear weapons commitment

The released document states that Iran has reaffirmed its commitment not to develop or acquire nuclear weapons. It also provides for cooperation with the International Atomic Energy Agency (IAEA) and further discussions on the future of Iran’s enriched uranium stockpiles as part of upcoming negotiations.

While the MoU establishes broad principles, several key nuclear issues are expected to be addressed during the 60-day negotiation process that follows the signing of the framework agreement.

$300 billion reconstruction fund proposed

One of the most significant economic elements of the agreement is a proposed $300 billion Reconstruction and Development Fund intended to support Iran’s recovery and investment needs. US officials have said the fund would be financed by private-sector investors and international partners rather than American taxpayers.

Officials have also stressed that access to the fund and broader economic benefits would depend on Iran meeting its commitments under the agreement, including compliance with nuclear-related obligations.

Next phase of negotiations

The memorandum establishes a 60-day period for negotiations on a final agreement covering sanctions, nuclear issues and broader regional security concerns. Both countries have pledged to avoid escalation during this period while working toward a longer-term settlement.

The deal is being viewed as an important step toward reducing tensions in the Middle East, though significant negotiations remain before a permanent agreement can be reached.

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