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China clones 5 gene-edited monkeys to aid disorder research

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[vc_row][vc_column][vc_column_text]On Thursday, Chinese scientists announced that they had cloned five monkeys from a single animal that was genetically engineered to have a sleep disorder, saying it could aid research into human psychological problems.

The claim, detailed in two reports published in a Chinese science journal, is the latest in a series of biomedical advances in the country, some of which have fuelled medical ethics debates.

Macaques are chiefly Asian monkeys typically having a sturdy build and including some short-tailed or tailless forms. The gene-edited macaque had circadian rhythm disorders associated with depression, diabetic, cancer and Alzheimer’s disease.

It is the first time multiple monkeys have been cloned from a gene-edited monkey for biomedical research, IANS quoted a Xinhua news agency report.

Poo Muming, the director of the neuroscience institute and the study’s co-author, told state media that the research team would seek to clone more monkeys with different brain disorders in hopes that future experiments on them could yield new drugs or treatment.

The cloned monkeys, closer to humans in terms of activity routines, brain structure and metabolic rate, make better models for research on disease pathogenesis and potential therapeutic treatments, according to the team from Institute of Neuroscience of Chinese Academy of Sciences in Shanghai.

To create an ideal donor monkey, the researchers knocked out BMAL1, a core circadian regulatory transcription factor, using gene editing at the embryo stage.

They selected one of the gene-edited monkeys with the most severe disease phenotypes as the donor.

The fibroblasts (the main connective tissue cells present in the body) of the donor were then used to clone five monkeys by somatic cell nuclear transfer, the same method used to generate Zhong Zhong and Hua Hua, the first cloned monkeys born in China at the end of 2017, the report published in the National Science Review journal revealed.

Different from Zhong Zhong and Hua Hua, generated by using fibroblasts from an aborted foetus, the new clones were made using a gene-edited young adult male monkey.

“It shows that besides using foetus, batch cloning of gene-edited male monkeys with diseases is also feasible,” Qiang Sun from the institute, was quoted as saying.

Sun stated the research programme was reviewed and supervised by the institute’s ethic committee in accordance with international ethical standards of animal research, the IANS report said.

In the future, the team plans would focus on cloning monkey models with different brain diseases.

Besides being used to study human brain diseases, the models will be used to test medicine effectiveness, which can help reduce the number of animal models used in experiments and lower the cost of medicine development, the report said.

(Inputs taken from media reports)[/vc_column_text][/vc_column][/vc_row]

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US-Iran talks move closer as $300 billion investment proposal emerges

The United States and Iran are said to be nearing a preliminary agreement that could include sanctions relief, access to frozen Iranian assets, a Lebanon ceasefire framework and a proposed $300 billion reconstruction-linked investment plan.

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The United States and Iran are reportedly edging closer to a preliminary agreement that could temporarily ease tensions in the Middle East while opening the door for wider negotiations on Iran’s nuclear programme, sanctions relief and regional security.

According to reports, the evolving framework may include discussions around a proposed $300 billion reconstruction and investment mechanism for Iran if a final agreement is eventually reached. The proposal is said to involve international investment support facilitated with US backing.

Lebanon and Strait of Hormuz among major discussion points

One of the key elements under discussion reportedly concerns reducing hostilities involving Israel and Hezbollah in Lebanon. The issue has emerged as a sensitive component of the broader negotiations, especially amid continued military activity in the region.

The talks are also focused on restoring commercial shipping movement through the Strait of Hormuz, a globally significant energy corridor disrupted during the ongoing conflict. Reports suggest Iran may be expected to help restore safe maritime navigation, while the United States could gradually ease aspects of its blockade depending on progress during negotiations.

Sanctions relief and frozen assets under consideration

Negotiators are also reportedly discussing phased sanctions relief and potential access to billions of dollars in Iranian funds frozen abroad. Iran has long demanded the release of such assets as part of any broader understanding with Washington.

The draft understanding is also expected to include commitments related to Iran’s nuclear activities, including further negotiations on enriched uranium stockpiles and assurances linked to nuclear weapons development.

Key differences still remain unresolved

Despite signs of progress, several differences reportedly remain unresolved between the two sides. Questions continue over the exact wording of the proposed framework, the duration of any ceasefire arrangement and the timeline for easing restrictions in the Strait of Hormuz.

Reports also indicate that mediation efforts involving regional actors, including Pakistan and Qatar, have played a major role in facilitating indirect talks between Washington and Tehran.

While officials from both sides have signalled progress, no final agreement has yet been formally announced.

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US carries out fresh strikes in Iran, downing drones near strategic Strait of Hormuz

The US military launched overnight defensive strikes targeting an Iranian military facility and shot down four attack drones near the Strait of Hormuz, highlighting the vulnerability of ongoing peace negotiations.

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Donald Trump statement

The US military launched overnight strikes inside Iran, targeting a military installation and intercepting multiple attack drones near the critical Strait of Hormuz. The operation comes amid intense diplomatic efforts to end a three-month-old war that has severely impacted global energy markets.

According to media reports citing US officials who spoke on condition of anonymity, American forces shot down four one-way attack drones. Additionally, a ground control facility located in the southern Iranian port city of Bandar Abbas—which was reportedly preparing to launch a fifth drone—was struck. Local residents in Iran reported hearing three distinct explosions east of Bandar Abbas around 1:30 AM local time, prompting the temporary activation of local air defense systems.

Focus on maintaining the ceasefire

US Central Command later confirmed the targeted actions, stating that the intercepted drones posed an immediate threat to American personnel and commercial shipping vessels operating near the strategic waterway. Officials described the intervention as a measured, defensive response aimed strictly at safeguarding international transit routes and preserving the active, yet fragile, ceasefire arrangement.

The Strait of Hormuz serves as a vital artery for global commerce, accounting for nearly one-fifth of global oil shipments before hostitilies erupted on February 28.

Strains on ongoing diplomatic talks

These recent military developments occurred against the backdrop of sensitive negotiations aimed at formalizing a permanent peace agreement. Earlier this week, the US conducted similar self-defense strikes against vessels allegedly deployed to lay naval mines, drawing sharp condemnation from Tehran, which labelled those actions a breach of the ceasefire.

Diplomatic tensions were further compounded on Wednesday when US President Donald Trump publicly dismissed reports claiming that Iran and Oman would jointly manage shipping operations through the Strait of Hormuz under a proposed peace deal, asserting instead that the international waterway must remain entirely open.

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Byju’s founder Byju Raveendran sentenced to six months in jail by Singapore court over asset orders

In a major setback, a Singapore court has sentenced Byju’s founder Byju Raveendran to six months in prison for contempt after he failed to comply with multiple court orders regarding his assets.

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In a massive legal blow to the founder of the failed Indian educational technology firm Think & Learn Pvt (better known as Byju’s), a Singapore court has sentenced Byju Raveendran to six months in jail for contempt of court.

The court ordered the jail term after concluding that Raveendran had deliberately disobeyed multiple judicial directives regarding his personal assets, dating as far back as April 2024.

Disobedience of asset orders leads to prison sentence

According to people familiar with the matter, the Singapore court has instructed Raveendran to immediately surrender himself to the officials. Alongside the six-month prison sentence, the Byju’s founder has been ordered to pay legal costs amounting to S$90,000 (approximately $70,500). Furthermore, he has been mandated to provide documents verifying his official legal ownership of Beeaar Investco Pte, a corporate entity that holds equity shares in a related firm.

At the time of reporting, it remains unclear whether Raveendran is currently residing in Singapore or located elsewhere, and he did not immediately respond to requests for comment.

Escalating global legal battles

This sentencing marks the latest and perhaps most severe setback for the entrepreneur, who once achieved billionaire status amid a massive wave of global capital flowing into Indian start-ups. Today, Raveendran is being rigorously pursued by foreign investors across international jurisdictions. This includes intensifying legal battles in the United States, where global lenders are actively trying to recover heavy financial losses stemming from a defaulted $1.2 billion loan.

Media reports indicate that the ongoing Singapore court proceedings represent a broadening web of legal and financial crises following the operational collapse of the once-celebrated edtech giant.

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